AAH20023.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Qpct protein
NCBI Official Synonym Full Names
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
NCBI Protein Information
glutaminyl-peptide cyclotransferase; QC; glutaminyl cyclase; glutaminyl-tRNA cyclotransferase
UniProt Protein Name
Glutaminyl-peptide cyclotransferase
UniProt Synonym Protein Names
Glutaminyl cyclase; QC; Glutaminyl-tRNA cyclotransferase
UniProt Synonym Gene Names
UniProt Entry Name
QPCT_MOUSE
UniProt Comments for Qpct
QPCT: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. Belongs to the glutaminyl-peptide cyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.3.2.5; Secreted; Secreted, signal peptide
Cellular Component: extracellular region
Molecular Function: transferase activity; glutaminyl-peptide cyclotransferase activity; zinc ion binding; metal ion binding; transferase activity, transferring acyl groups
Biological Process: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Research Articles on Qpct
Precautions
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Disclaimer
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Diseases associated with anti-Qpct antibody
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>7 publications with Qpct and Neoplasms |
Inflammation Antibodies |
>2 publications with Qpct and Inflammation |
Nervous System Diseases Antibodies |
>1 publications with Qpct and Nervous System Diseases |
Fibrosis Antibodies |
>1 publications with Qpct and Fibrosis |
Disease Models, Animal Antibodies |
>1 publications with Qpct and Disease Models, Animal |
Kidney Diseases Antibodies |
>1 publications with Qpct and Kidney Diseases |
Neoplasms, Experimental Antibodies |
>1 publications with Qpct and Neoplasms, Experimental |
Hyperplasia Antibodies |
>1 publications with Qpct and Hyperplasia |
Leukemia, Lymphocytic, Chronic, B-Cell Antibodies |
>1 publications with Qpct and Leukemia, Lymphocytic, Chronic, B-Cell |
Brain Diseases Antibodies |
>1 publications with Qpct and Brain Diseases |
Organs/Tissues associated with anti-Qpct antibody
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