NP_071520.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
NCBI Official Full Name
peripheral plasma membrane protein CASK
NCBI Official Synonym Full Names
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
NCBI Protein Information
peripheral plasma membrane protein CASK
UniProt Protein Name
Peripheral plasma membrane protein CASK
UniProt Synonym Protein Names
Calcium/calmodulin-dependent serine protein kinase
UniProt Entry Name
CSKP_RAT
NCBI Summary for Cask
may play a role in intracellular Ca(2+) mediated signaling pathways [RGD, Feb 2006]
UniProt Comments for Cask
CASK: a MAGUK family protein and a protein kinase of the CAMK group. Contains one protein kinase domain, one guanylate kinase domain, two L27 domains, one PDZ domain and one SH3 domain. Plays a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Lacks the canonical DFG motif required for Mg++ binding, but retains protein kinase activity even without binding Mg++. Six alternatively spliced human isoforms have been described.
Protein type: Protein kinase, Ser/Thr (non-receptor); Adaptor/scaffold; Protein kinase, CAMK; EC 2.7.11.1; Kinase, protein; CAMK group; CASK family
Cellular Component: focal adhesion; protein complex; nuclear matrix; basolateral plasma membrane; dendrite; integral to membrane; intercellular junction; cytosol; presynaptic membrane; nuclear lamina; membrane; cytoplasm; plasma membrane; nucleolus; basement membrane; synapse; nucleus
Molecular Function: protein C-terminus binding; calmodulin binding; G-protein coupled receptor activity; protein binding; calmodulin-dependent protein kinase activity; neurexin binding; transcription coactivator activity; protein complex binding; ATP binding; PDZ domain binding
Biological Process: intracellular protein transport; G-protein coupled receptor protein signaling pathway; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell-matrix adhesion; protein amino acid phosphorylation
Product References and Citations for anti-Cask antibody
Hata Y., et al. J. Neurosci. 16:2488-2494(1996). Butz S., et al. Cell 94:773-782(1998). Hsueh Y.P., et al. Nature 404:298-302(2000). Tabuchi K., et al. J. Neurosci. 22:4264-4273(2002). Chetkovich D.M., et al. J. Neurosci. 22:6415-6425(2002).
Research Articles on Cask
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-Cask antibody
Diseases associated with anti-Cask antibody
Organs/Tissues associated with anti-Cask antibody
|