NP_446276.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
casein kinase II subunit alpha
NCBI Official Synonym Full Names
casein kinase 2, alpha 1 polypeptide
NCBI Protein Information
casein kinase II subunit alpha
UniProt Protein Name
Casein kinase II subunit alpha
UniProt Synonym Gene Names
UniProt Entry Name
CSK21_RAT
NCBI Summary for Csnk2a1
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
UniProt Comments for Csnk2a1
CK2A1: an ubiquitous protein kinase of the CK2 family. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. The isoforms are rarely specified in publications. Two splice variant isoforms have been found. Participates in Wnt signaling. Phosphorylates E2 ubiquitin conjugating enzyme UBC3B inducing its interaction with beta-TRCp and enhancing beta-catenin degradation. May control IkB-alpha and p27Kip1 degradation. component of a CK2-SPT16-SSRP1 complex composed of SSRP1, PT16 CK2-A1, CK2-A2 and CK2-B the complex associating following UV irradiation. Interacts with RNPS1. Mouse transgene causes mammary gland hyperplasia and lymphoma, and activation by bovine parasites leads to fatal lymphoproliferation. Expression and activity are elevated in lung tumors and breast tumors. Antisense drives apoptosis of tumor cell lines and xenografts. Involved in DNA break repair by phosphorylation of scaffold protein XRCC1, phosphorylation of BRCA1, and phosphorylation of p53 in response to UV irradiation. Drosophila CK2 (Timekeeper) is involved in circadian regulation. Phosphorylates and binds to a major component of the inclusion bodies seen in Parkinson?s patients. Inhibitors: 4,5,6,7-tetrabromobenzotriazole (TBB).
Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Other group; CK2 family
Cellular Component: Sin3 complex; protein kinase CK2 complex; NuRD complex; PcG protein complex; nucleus
Molecular Function: protein serine/threonine kinase activity; protein phosphatase regulator activity; beta-catenin binding; protein N-terminus binding; kinase activity; ATP binding
Biological Process: Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of catalytic activity; protein amino acid autophosphorylation; positive regulation of cell proliferation; rhythmic process; positive regulation of protein catabolic process; regulation of cell growth; negative regulation of caspase activity; positive regulation of cell growth; protein amino acid phosphorylation; positive regulation of Wnt receptor signaling pathway; regulation of cell proliferation
Product References and Citations for anti-Csnk2a1 antibody
Ahmed K., et al. Cell. Mol. Biol. Res. 39:451-462(1993). Meisner H., et al. Biochemistry 28:4072-4076(1989). Li P.F., et al. Mol. Cell 10:247-258(2002). Zhou W., et al. Chin. Sci. Bull. 54:220-226(2009).
Research Articles on Csnk2a1
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Products associated with anti-Csnk2a1 antibody
Pathways associated with anti-Csnk2a1 antibody
Diseases associated with anti-Csnk2a1 antibody
Organs/Tissues associated with anti-Csnk2a1 antibody
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