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anti-Dusp6 antibody :: Rabbit anti-Rat R MKP3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9214713
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

R MKP3 (Dusp6), Polyclonal Antibody

 Also Known As   

R MKP3 Antibody

 Product Synonym Names    Dual specificity protein phosphatase 6; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3; Dusp6; Mkp3
 Product Gene Name   

anti-Dusp6 antibody

[Similar Products]
 Antibody/Peptide Pairs    R MKP3 peptide (MBS9228532) is used for blocking the activity of R MKP3 antibody (MBS9214713)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q64346
 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    This Rat MKP3 antibody is generated from rabbits immunized with a 6xHIS-tagged recombinant protein encoding aa 1~381 of rat MKP3.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by dialysis against PBS.
 Concentration    Vial Concentration: 2 (lot specific)
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 Antigen Type    Recombinant Protein
 Antigen Source    RAT
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-Dusp6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Dusp6 antibody

   Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of MAP kinases by dephosphorylating critical tyrosine and threonine residues. MKP-3 is 36% identical to MKP-1 and it blocks both the phosphorylation and enzymatic activation of ERK2 by mitogens. MKP-3 mRNA is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis
 Product Categories/Family for anti-Dusp6 antibody    Neuroscience
 Applications Tested/Suitable for anti-Dusp6 antibody   

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)

 Application Notes for anti-Dusp6 antibody    WB~~1:1000
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 Western Blot (WB) of anti-Dusp6 antibody    Western blot analysis of MKP3 (arrow) using rabbit polyclonal MKP3-His6 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MKP3 gene.
anti-Dusp6 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-Dusp6 antibody    Rat MKP3 Antibody flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-Dusp6 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for Dusp6. It may not necessarily be applicable to this product.
 NCBI GI #    16758752
 NCBI GeneID    116663
 NCBI Accession #    NP_446335.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053883.2 [Other Products]
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 UniProt Primary Accession #    Q64346 [Other Products]
 UniProt Related Accession #    Q64346 [Other Products]
 Molecular Weight    42319
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 NCBI Official Full Name    dual specificity protein phosphatase 6
 NCBI Official Synonym Full Names    dual specificity phosphatase 6
 NCBI Official Symbol    Dusp6 [Similar Products]
 NCBI Official Synonym Symbols   
Mkp3
[Similar Products]
 NCBI Protein Information    dual specificity protein phosphatase 6
 UniProt Protein Name    Dual specificity protein phosphatase 6
 UniProt Synonym Protein Names   
Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3
 Protein Family    Dual specificity protein phosphatase
 UniProt Gene Name    Dusp6 [Similar Products]
 UniProt Synonym Gene Names    Mkp3; MAP kinase phosphatase 3; MKP-3 [Similar Products]
 UniProt Entry Name    DUS6_RAT
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 NCBI Summary for Dusp6    protein tyrosine phosphatase involved in regulation of mitogen-activated protein kinase (MAPK) [RGD, Feb 2006]
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 UniProt Comments for Dusp6    MKP-3: a non-receptor, dual-specificity phosphoprotein phosphatase. Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This protein inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity

Cellular Component: cytoplasm; cytosol

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: response to organic substance; response to drug; response to nitrosative stress; negative regulation of protein amino acid phosphorylation; dorsal/ventral pattern formation; positive regulation of apoptosis; regulation of fibroblast growth factor receptor signaling pathway; regulation of endodermal cell fate specification; protein amino acid dephosphorylation; cell differentiation; response to organic cyclic substance; inactivation of MAPK activity
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Product References and Citations for anti-Dusp6 antibody

   Muda,M., et al. J. Biol. Chem. 271 (8), 4319-4326 (1996)
Mourey,R.J., et al. J. Biol. Chem. 271 (7), 3795-3802 (1996)
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 Research Articles on Dusp6    1. data demonstrate THAT MKP-3 has differential substrate preference in astrocytes compared to other cells types, since it preferentially dephosphorylated p-JNK over p-ERK.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Dusp6 antibodyDiseases associated with anti-Dusp6 antibody
 Reference Product  PubMed Publications
 Mapk1 antibody  >46 publications with Dusp6 and Mapk1
 Mapk3 antibody  >35 publications with Dusp6 and Mapk3
 Ngf antibody  >3 publications with Dusp6 and Ngf
 Mapk8 antibody  >2 publications with Dusp6 and Mapk8
 Mapk14 antibody  >2 publications with Dusp6 and Mapk14
 Mapk12 antibody  >1 publications with Dusp6 and Mapk12
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >40 publications with Dusp6 and Carcinoma
 Lung Neoplasms Antibodies  >16 publications with Dusp6 and Lung Neoplasms
 Inflammation Antibodies  >13 publications with Dusp6 and Inflammation
 Breast Neoplasms Antibodies  >9 publications with Dusp6 and Breast Neoplasms
 Brain Diseases Antibodies  >9 publications with Dusp6 and Brain Diseases
 Cardiovascular Diseases Antibodies  >9 publications with Dusp6 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >6 publications with Dusp6 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >6 publications with Dusp6 and Neoplasms, Experimental
 Heart Diseases Antibodies  >5 publications with Dusp6 and Heart Diseases
 Liver Neoplasms Antibodies  >4 publications with Dusp6 and Liver Neoplasms
Organs/Tissues associated with anti-Dusp6 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >27 publications with Dusp6 and Brain
 Lung Antibodies  >22 publications with Dusp6 and Lung
 Muscle Antibodies  >14 publications with Dusp6 and Muscle
 Heart Antibodies  >13 publications with Dusp6 and Heart
 Liver Antibodies  >10 publications with Dusp6 and Liver
 Embryonic Tissue Antibodies  >10 publications with Dusp6 and Embryonic Tissue
 Kidney Antibodies  >6 publications with Dusp6 and Kidney
 Prostate Antibodies  >3 publications with Dusp6 and Prostate
 Spleen Antibodies  >2 publications with Dusp6 and Spleen
 Inner Ear Antibodies  >1 publications with Dusp6 and Inner Ear
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