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anti-RSPO2 antibody :: Rabbit R-spondin 2 homolog Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713628 anti-RSPO2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

R-spondin 2 homolog (RSPO2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human R-spondin 2 homolog (Xenopus laevis) polyclonal Antibody

 Product Synonym Names    R-spondin 2 homolog (Xenopus laevis); RSPO2; CRISTIN2; MGC35555; MGC43342
 Product Gene Name   

anti-RSPO2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610575
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human RSPO2
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-74883 / sc-74886 / sc-292494
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RSPO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RSPO2 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for RSPO2. It may not necessarily be applicable to this product.
 NCBI GI #    544583460
 NCBI GeneID    340419
 NCBI Accession #    NP_001269792.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001282863.1 [Other Products]
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 UniProt Secondary Accession #    Q4G0U4; Q8N6X6; B3KVP0 [Other Products]
 UniProt Related Accession #    Q6UXX9 [Other Products]
 Molecular Weight    20,972 Da [Similar Products]
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 NCBI Official Full Name    R-spondin-2 isoform 2
 NCBI Official Synonym Full Names    R-spondin 2
 NCBI Official Symbol    RSPO2 [Similar Products]
 NCBI Official Synonym Symbols   
CRISTIN2
[Similar Products]
 NCBI Protein Information    R-spondin-2; R-spondin 2 homolog; roof plate-specific spondin-2
 UniProt Protein Name    R-spondin-2
 UniProt Synonym Protein Names   
Roof plate-specific spondin-2; hRspo2
 Protein Family    R-spondin
 UniProt Gene Name    RSPO2 [Similar Products]
 UniProt Synonym Gene Names    hRspo2 [Similar Products]
 UniProt Entry Name    RSPO2_HUMAN
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 NCBI Summary for RSPO2    R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for RSPO2    R-spondin-2: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q23.1

Cellular Component: extracellular space; cell surface; extracellular region

Molecular Function: heparin binding; G-protein-coupled receptor binding; receptor binding

Biological Process: osteoblast differentiation; embryonic forelimb morphogenesis; Wnt receptor signaling pathway; embryonic hindlimb morphogenesis; bone mineralization
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 Research Articles on RSPO2    1. Oocyte-derived R-spondin2 is a paracrine factor essential for primary ovarian follicle development
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RSPO2 antibodyPathways associated with anti-RSPO2 antibody
 Reference Product  PubMed Publications
 PTPRK antibody  >2 publications with RSPO2 and PTPRK
 SP8 antibody  >2 publications with RSPO2 and SP8
 WNT11 antibody  >1 publications with RSPO2 and WNT11
 FGF5 antibody  >1 publications with RSPO2 and FGF5
 KRT71 antibody  >1 publications with RSPO2 and KRT71
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
 Regulation Of FZD By Ubiquitination Pathway antibodies  Regulation Of FZD By Ubiquitination Pathway Diagram
Diseases associated with anti-RSPO2 antibodyOrgans/Tissues associated with anti-RSPO2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with RSPO2 and Nervous System Diseases
 Adenocarcinoma Antibodies  >3 publications with RSPO2 and Adenocarcinoma
 Hyperplasia Antibodies  >3 publications with RSPO2 and Hyperplasia
 Carcinoma, Hepatocellular Antibodies  >2 publications with RSPO2 and Carcinoma, Hepatocellular
 Fibrosis Antibodies  >2 publications with RSPO2 and Fibrosis
 Mammary Neoplasms, Animal Antibodies  >1 publications with RSPO2 and Mammary Neoplasms, Animal
 Urogenital Abnormalities Antibodies  >1 publications with RSPO2 and Urogenital Abnormalities
 Brain Diseases Antibodies  >1 publications with RSPO2 and Brain Diseases
 Liver Diseases Antibodies  >1 publications with RSPO2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >5 publications with RSPO2 and Muscle
 Lung Antibodies  >4 publications with RSPO2 and Lung
 Blood Antibodies  >3 publications with RSPO2 and Blood
 Intestine Antibodies  >3 publications with RSPO2 and Intestine
 Brain Antibodies  >3 publications with RSPO2 and Brain
 Embryonic Tissue Antibodies  >2 publications with RSPO2 and Embryonic Tissue
 Liver Antibodies  >2 publications with RSPO2 and Liver
 Ear Antibodies  >1 publications with RSPO2 and Ear
 Skin Antibodies  >1 publications with RSPO2 and Skin
 Testis Antibodies  >1 publications with RSPO2 and Testis
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