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anti-RABGEF1 antibody :: Rabbit RAB guanine nucleotide exchange factor (GEF) 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712114 anti-RABGEF1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAB guanine nucleotide exchange factor (GEF) 1 (RABGEF1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human RAB guanine nucleotide exchange factor (GEF) 1 polyclonal Antibody

 Product Synonym Names    RAB guanine nucleotide exchange factor (GEF) 1; RABGEF1; FLJ32302; RABEX5; rabex-5
 Product Gene Name   

anti-RABGEF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609700
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human RABGEF1
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68344
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RABGEF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RABGEF1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for RABGEF1. It may not necessarily be applicable to this product.
 NCBI GI #    119628321
 NCBI GeneID    27342
 NCBI Accession #    EAX07916.1 [Other Products]
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 UniProt Secondary Accession #    Q3HKR2; Q3HKR3; Q53FG0; B4DZM7 [Other Products]
 UniProt Related Accession #    Q9UJ41 [Other Products]
 Molecular Weight    58,526 Da [Similar Products]
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 NCBI Official Full Name    RAB guanine nucleotide exchange factor (GEF) 1, isoform CRA_b
 NCBI Official Synonym Full Names    RAB guanine nucleotide exchange factor (GEF) 1
 NCBI Official Symbol    RABGEF1 [Similar Products]
 NCBI Official Synonym Symbols   
RAP1; RABEX5; rabex-5
[Similar Products]
 NCBI Protein Information    rab5 GDP/GTP exchange factor; rabaptin-5-associated exchange factor for Rab5
 UniProt Protein Name    Rab5 GDP/GTP exchange factor
 UniProt Synonym Protein Names   
RAP1; Rabaptin-5-associated exchange factor for Rab5; Rabex-5
 Protein Family    Rab5 GDP/GTP exchange factor
 UniProt Gene Name    RABGEF1 [Similar Products]
 UniProt Synonym Gene Names    RABEX5 [Similar Products]
 UniProt Entry Name    RABX5_HUMAN
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 NCBI Summary for RABGEF1    RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]
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 UniProt Comments for RABGEF1    RABGEF1: Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Interacts with RGS14; the interaction is GTP-dependent. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; GAPs, Rab

Chromosomal Location of Human Ortholog: 7q11.21

Cellular Component: recycling endosome; early endosome; vesicle

Molecular Function: protein binding; DNA binding; zinc ion binding; ubiquitin-protein ligase activity; Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding

Biological Process: negative regulation of protein amino acid phosphorylation; negative regulation of mast cell degranulation; negative regulation of inflammatory response; protein ubiquitination; negative regulation of Ras protein signal transduction; endocytosis; negative regulation of receptor-mediated endocytosis; protein targeting to membrane; negative regulation of leukocyte migration
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 Research Articles on RABGEF1    1. RABEX-5 mRNA expression is a strong predictor of poor prognosis in prostate cancer patients treated by radical prostatectomy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RABGEF1 antibodyDiseases associated with anti-RABGEF1 antibody
 Reference Product  PubMed Publications
 RABEP1 antibody  >7 publications with RABGEF1 and RABEP1
 EEA1 antibody  >2 publications with RABGEF1 and EEA1
 RAB5A antibody  >2 publications with RABGEF1 and RAB5A
 RABEP2 antibody  >1 publications with RABGEF1 and RABEP2
 GGA1 antibody  >1 publications with RABGEF1 and GGA1
 RAB21 antibody  >1 publications with RABGEF1 and RAB21
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with RABGEF1 and Inflammation
 Adenocarcinoma Antibodies  >1 publications with RABGEF1 and Adenocarcinoma
 Atrophy Antibodies  >1 publications with RABGEF1 and Atrophy
 Genital Diseases, Male Antibodies  >1 publications with RABGEF1 and Genital Diseases, Male
 Weight Loss Antibodies  >1 publications with RABGEF1 and Weight Loss
 Kidney Diseases Antibodies  >1 publications with RABGEF1 and Kidney Diseases
 Hyperplasia Antibodies  >1 publications with RABGEF1 and Hyperplasia
Organs/Tissues associated with anti-RABGEF1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with RABGEF1 and Brain
 Blood Antibodies  >5 publications with RABGEF1 and Blood
 Skin Antibodies  >4 publications with RABGEF1 and Skin
 Lymph Antibodies  >3 publications with RABGEF1 and Lymph
 Lymph Node Antibodies  >3 publications with RABGEF1 and Lymph Node
 Bone Antibodies  >2 publications with RABGEF1 and Bone
 Stomach Antibodies  >1 publications with RABGEF1 and Stomach
 Thyroid Antibodies  >1 publications with RABGEF1 and Thyroid
 Spleen Antibodies  >1 publications with RABGEF1 and Spleen
 Prostate Antibodies  >1 publications with RABGEF1 and Prostate
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