NP_004628.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ras-related protein Rab-7a
NCBI Official Synonym Full Names
RAB7A, member RAS oncogene family
NCBI Protein Information
ras-related protein Rab-7a; Ras-associated protein RAB7; RAB7, member RAS oncogene family
UniProt Protein Name
Ras-related protein Rab-7a
UniProt Synonym Gene Names
UniProt Entry Name
RAB7A_HUMAN
NCBI Summary for RAB7A
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]
UniProt Comments for RAB7A
Function: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Ref.8 Ref.10 Ref.11 Ref.23
Subunit structure: The GTP-bound form interacts with RAC1
By similarity. Interacts with NTRK1/TRKA
By similarity. Interacts with RILP, PSMA7, RNF115 and FYCO1. Interacts with the PIK3C3/VPS34-PIK3R4 complex. The GTP-bound form interacts with OSBPL1A. Interacts with CLN3. Ref.8 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16 Ref.19 Ref.24
Subcellular location: Late endosome. Lysosome
By similarity. Cytoplasmic vesicle › phagosome
By similarity. Melanosome
By similarity. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side. Note: Colocalizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium
By similarity. Ref.9 Ref.10 Ref.11 Ref.14 Ref.15 Ref.23
Tissue specificity: Widely expressed; high expression found in skeletal muscle. Ref.26
Involvement in disease: Charcot-Marie-Tooth disease 2B (CMT2B) [MIM:600882]: A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.26 Ref.27 Ref.28 Ref.29
Sequence similarities: Belongs to the small GTPase superfamily. Rab family.
Sequence caution: The sequence BAA91390.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.The sequence BAF83410.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.The sequence EAW79303.1 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on RAB7A
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Products associated with anti-RAB7A antibody
Pathways associated with anti-RAB7A antibody
Diseases associated with anti-RAB7A antibody
Organs/Tissues associated with anti-RAB7A antibody
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