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anti-RAB8A antibody :: Goat RAB8A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421586
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAB8A, Polyclonal Antibody

 Also Known As   

Goat anti-RAB8A Antibody

 Product Synonym Names    RAB8A; RAB8A, member RAS oncogene family; MEL; RAB8; mel transforming oncogene; mel transforming oncogene (RAB8 homolog); mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; ras-a; RAB8A antibody; RAB8A; member RAS oncogene family antibody; MEL antibody; RAB8 antibody; mel transforming oncogene antibody; mel transforming oncogene (RAB8 homolog) antibody; mel transforming oncogene (derived from cell line NK14) antibody; mel transforming oncogene (derived from cell line NK14)- RAB8 homolog antibody; ras-associated protein RAB8 antibody
 Product Gene Name   

anti-RAB8A antibody

[Similar Products]
 Antibody/Peptide Pairs    RAB8A peptide (MBS426539) is used for blocking the activity of RAB8A antibody (MBS421586)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    NQGVKITPDQ QKR
 OMIM    165040
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-NQGVKITPDQQKR, from the C Terminus of the protein sequence according to NP_005361.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-RAB8A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RAB8A antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-RAB8A antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 25kDa band observed in Human Brain (Cerebellum), Kidney and Heart lysates (calculated MW of 23.7kDa according to NP_005361.2). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-RAB8A antibody    (0.1ug/ml) staining of Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-RAB8A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for RAB8A. It may not necessarily be applicable to this product.
 NCBI GI #    16933567
 NCBI GeneID    4218
 NCBI Accession #    NP_005361.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005370.4 [Other Products]
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 UniProt Secondary Accession #    P24407; Q6FHV5; B4DEK7 [Other Products]
 UniProt Related Accession #    P61006 [Other Products]
 Molecular Weight    23,564 Da
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 NCBI Official Full Name    ras-related protein Rab-8A
 NCBI Official Synonym Full Names    RAB8A, member RAS oncogene family
 NCBI Official Symbol    RAB8A [Similar Products]
 NCBI Official Synonym Symbols   
MEL; RAB8
[Similar Products]
 NCBI Protein Information    ras-related protein Rab-8A
 UniProt Protein Name    Ras-related protein Rab-8A
 UniProt Synonym Protein Names   
Oncogene c-mel
 Protein Family    Ras-related protein
 UniProt Gene Name    RAB8A [Similar Products]
 UniProt Synonym Gene Names    MEL; RAB8 [Similar Products]
 UniProt Entry Name    RAB8A_HUMAN
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 NCBI Summary for RAB8A    The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RAB8A    RAB8A: May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3. Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B. Interacts with PIFO/C1orf88. Interacts with BIRC6/bruce. Interacts with OCRL. Belongs to the small GTPase superfamily. Rab family.

Protein type: Oncoprotein; G protein, monomeric, Rab; G protein, monomeric; G protein; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: cell soma; centriole; centrosome; cilium; cytoplasmic vesicle membrane; cytosol; dendrite; Golgi membrane; nonmotile primary cilium; nucleolus; nucleus; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; postsynaptic density; recycling endosome membrane; synaptic vesicle; trans-Golgi network transport vesicle

Molecular Function: GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding; protein kinase binding; Rab GTPase binding

Biological Process: axonogenesis; cellular response to insulin stimulus; cilium biogenesis; G2/M transition of mitotic cell cycle; Golgi vesicle fusion to target membrane; intracellular protein transport; metabolic process; nucleocytoplasmic transport; protein secretion; regulation of long-term neuronal synaptic plasticity; regulation of protein transport; small GTPase mediated signal transduction; vesicle docking during exocytosis
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 Research Articles on RAB8A    1. the role of Rabin8 (a mammalian ortholog of Sec2p) with Rab8-nucleotide-exchange factor activity in autophagy in mammalian cells, was examined.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RAB8A antibodyPathways associated with anti-RAB8A antibody
 Reference Product  PubMed Publications
 TBC1D4 antibody  >6 publications with RAB8A and TBC1D4
 OPTN antibody  >5 publications with RAB8A and OPTN
 RAB1B antibody  >3 publications with RAB8A and RAB1B
 OCRL antibody  >2 publications with RAB8A and OCRL
 CCP110 antibody  >1 publications with RAB8A and CCP110
 RAB3IP antibody  >1 publications with RAB8A and RAB3IP
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
Diseases associated with anti-RAB8A antibodyOrgans/Tissues associated with anti-RAB8A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >15 publications with RAB8A and Nervous System Diseases
 Kidney Diseases Antibodies  >5 publications with RAB8A and Kidney Diseases
 Movement Disorders Antibodies  >3 publications with RAB8A and Movement Disorders
 Heart Diseases Antibodies  >2 publications with RAB8A and Heart Diseases
 Ataxia Antibodies  >1 publications with RAB8A and Ataxia
 Liver Diseases Antibodies  >1 publications with RAB8A and Liver Diseases
 Inflammation Antibodies  >1 publications with RAB8A and Inflammation
 Cognition Disorders Antibodies  >1 publications with RAB8A and Cognition Disorders
 Weight Loss Antibodies  >1 publications with RAB8A and Weight Loss
 Fatty Liver Antibodies  >1 publications with RAB8A and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >19 publications with RAB8A and Kidney
 Brain Antibodies  >15 publications with RAB8A and Brain
 Eye Antibodies  >13 publications with RAB8A and Eye
 Intestine Antibodies  >9 publications with RAB8A and Intestine
 Muscle Antibodies  >7 publications with RAB8A and Muscle
 Nerve Antibodies  >6 publications with RAB8A and Nerve
 Blood Antibodies  >5 publications with RAB8A and Blood
 Heart Antibodies  >3 publications with RAB8A and Heart
 Liver Antibodies  >3 publications with RAB8A and Liver
 Bladder Antibodies  >2 publications with RAB8A and Bladder
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