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anti-RAC1 antibody :: Rabbit RAC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9127955
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAC1, Polyclonal Antibody

★Popular Item★
 Also Known As   

RAC1 Polyclonal Antibody

 Product Gene Name   

anti-RAC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602048
 3D Structure    ModBase 3D Structure for P63000
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human RAC1
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-RAC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RAC1 antibody

   The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.
 Applications Tested/Suitable for anti-RAC1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluoresence (IF)

 Application Notes for anti-RAC1 antibody    WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
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 Western Blot (WB) of anti-RAC1 antibody    Western blot analysis of extracts of various cell lines, using RAC1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
anti-RAC1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RAC1 antibody    Immunohistochemistry of paraffin-embedded human gastric using RAC1 antibody at dilution of 1:100 (40x lens).
anti-RAC1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-RAC1 antibody    Immunofluorescence analysis of A549 cells using RAC1 antibody. Blue: DAPI for nuclear staining.
anti-RAC1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for RAC1. It may not necessarily be applicable to this product.
 NCBI GI #    9845511
 NCBI GeneID    5879
 NCBI Accession #    NP_008839.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006908.4 [Other Products]
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 UniProt Primary Accession #    P63000 [Other Products]
 UniProt Secondary Accession #    O95501; P15154; Q3Y4D3; Q5JAA8; Q9BTB4 [Other Products]
 UniProt Related Accession #    P63000; AAB22206 [Other Products]
 Molecular Weight    21kDa
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 NCBI Official Full Name    ras-related C3 botulinum toxin substrate 1 isoform Rac1
 NCBI Official Synonym Full Names    ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
 NCBI Official Symbol    RAC1 [Similar Products]
 NCBI Official Synonym Symbols   
MIG5; Rac-1; TC-25; p21-Rac1
[Similar Products]
 NCBI Protein Information    ras-related C3 botulinum toxin substrate 1
 UniProt Protein Name    Ras-related C3 botulinum toxin substrate 1
 UniProt Synonym Protein Names   
Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1
 Protein Family    Ras-related protein
 UniProt Gene Name    RAC1 [Similar Products]
 UniProt Synonym Gene Names    TC25 [Similar Products]
 UniProt Entry Name    RAC1_HUMAN
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 NCBI Summary for RAC1    The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for RAC1    RAC1: a plasma membrane-associated member of the Rho-GTPase family. Plays a key role in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the downstream signal transduction pathway. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein; G protein, monomeric, Rho

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: extrinsic to plasma membrane; Golgi membrane; focal adhesion; membrane; lamellipodium; cytoplasm; plasma membrane; melanosome; actin filament; trans-Golgi network; cytosol; phagocytic cup

Molecular Function: GTPase activity; protein binding; enzyme binding; GTP binding; GTP-dependent protein binding; thioesterase binding; Rho GDP-dissociation inhibitor binding; protein kinase binding; Rab GTPase binding

Biological Process: nerve growth factor receptor signaling pathway; viral reproduction; positive regulation of apoptosis; metabolic process; cell motility involved in cell locomotion; regulation of cell migration; small GTPase mediated signal transduction; positive regulation of stress fiber formation; cell adhesion; bone resorption; platelet activation; anatomical structure morphogenesis; mast cell chemotaxis; dendrite morphogenesis; positive regulation of Rho protein signal transduction; regulation of defense response to virus by virus; negative regulation of interleukin-23 production; T cell costimulation; cerebral cortex radially oriented cell migration; actin cytoskeleton organization and biogenesis; axon guidance; cell-matrix adhesion; localization within membrane; positive regulation of focal adhesion formation; actin filament polymerization; ephrin receptor signaling pathway; response to wounding; inflammatory response; regulation of hydrogen peroxide metabolic process; lamellipodium biogenesis; intercellular junction assembly and maintenance; embryonic olfactory bulb interneuron precursor migration; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of phosphoinositide 3-kinase activity; engulfment of apoptotic cell; G-protein coupled receptor protein signaling pathway; cell proliferation; hyperosmotic response; positive regulation of actin filament polymerization; organization of an anatomical structure; auditory receptor cell morphogenesis; ruffle organization and biogenesis; innate immune response; negative regulation of receptor-mediated endocytosis; positive regulation of protein amino acid phosphorylation; cell motility; blood coagulation; vascular endothelial growth factor receptor signaling pathway; positive regulation of DNA replication
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 Research Articles on RAC1    1. It regulates actin polymerization to form lamellipodia, which is a critical event for cell migration of prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-RAC1 antibodyDiseases associated with anti-RAC1 antibody
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of Rac Pathway antibodies  Activation Of Rac Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >309 publications with RAC1 and Cardiovascular Diseases
 Inflammation Antibodies  >304 publications with RAC1 and Inflammation
 Neoplasm Metastasis Antibodies  >247 publications with RAC1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >233 publications with RAC1 and Disease Models, Animal
 Necrosis Antibodies  >184 publications with RAC1 and Necrosis
 Brain Diseases Antibodies  >172 publications with RAC1 and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >161 publications with RAC1 and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >139 publications with RAC1 and Heart Diseases
 Hypertension Antibodies  >130 publications with RAC1 and Hypertension
 Fibrosis Antibodies  >115 publications with RAC1 and Fibrosis
Organs/Tissues associated with anti-RAC1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >938 publications with RAC1 and Blood
 Vascular Antibodies  >772 publications with RAC1 and Vascular
 Brain Antibodies  >592 publications with RAC1 and Brain
 Muscle Antibodies  >515 publications with RAC1 and Muscle
 Lung Antibodies  >352 publications with RAC1 and Lung
 Nerve Antibodies  >334 publications with RAC1 and Nerve
 Kidney Antibodies  >310 publications with RAC1 and Kidney
 Heart Antibodies  >288 publications with RAC1 and Heart
 Bone Antibodies  >241 publications with RAC1 and Bone
 Embryonic Tissue Antibodies  >178 publications with RAC1 and Embryonic Tissue
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