NP_001265551.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,156 Da
NCBI Official Full Name
cell cycle checkpoint protein RAD17 isoform 1
NCBI Official Synonym Full Names
RAD17 homolog (S. pombe)
NCBI Official Synonym Symbols
CCYC; R24L; RAD24; HRAD17; RAD17SP [Similar Products]
NCBI Protein Information
cell cycle checkpoint protein RAD17; RAD1 homolog; RF-C activator 1 homolog; RF-C/activator 1 homolog; Rad17-like protein
UniProt Protein Name
Cell cycle checkpoint protein RAD17
UniProt Synonym Protein Names
RF-C/activator 1 homolog
UniProt Synonym Gene Names
UniProt Entry Name
RAD17_HUMAN
NCBI Summary for RAD17
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
UniProt Comments for RAD17
RAD17: a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. Binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. Phosphorylated and activated after DNA damage, inducing cell cycle G2 arrest. Eight alternatively spliced variants have been reported.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 5q13
Cellular Component: nucleoplasm; chromosome, telomeric region; nucleus
Molecular Function: protein binding; ATP binding
Biological Process: regulation of phosphorylation; negative regulation of DNA replication; mitotic cell cycle checkpoint; DNA damage checkpoint; DNA replication; DNA replication checkpoint; DNA repair; response to DNA damage stimulus
Research Articles on RAD17
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Products associated with anti-RAD17 antibody
Pathways associated with anti-RAD17 antibody
Diseases associated with anti-RAD17 antibody
Organs/Tissues associated with anti-RAD17 antibody
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