CAG38796.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,780 Da
NCBI Official Full Name
RAD51
NCBI Official Synonym Full Names
RAD51 recombinase
NCBI Official Synonym Symbols
RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930 [Similar Products]
NCBI Protein Information
DNA repair protein RAD51 homolog 1; BRCA1/BRCA2-containing complex, subunit 5; RAD51 homolog A; RecA, E. coli, homolog of; RecA-like protein; recombination protein A
UniProt Protein Name
DNA repair protein RAD51 homolog 1
UniProt Synonym Protein Names
RAD51 homolog A
UniProt Synonym Gene Names
UniProt Entry Name
RAD51_HUMAN
NCBI Summary for RAD51
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
UniProt Comments for RAD51
RAD51: a member of the RAD51 protein family. Involved in the homologous recombination and repair of DNA. Interacts with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Interacts with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both its intracellular localization and DNA-binding ability. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Defects in RAD51 are associated with breast cancer. Two alternatively spliced isoforms have been reported.
Protein type: DNA repair, damage; Mitochondrial
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: nucleoplasm; lateral element; nuclear chromosome; PML body; condensed nuclear chromosome; mitochondrion; perinuclear region of cytoplasm; mitochondrial matrix; cytoplasm; nucleolus; microtubule organizing center; condensed chromosome; nucleus
Molecular Function: protein C-terminus binding; identical protein binding; protein binding; double-stranded DNA binding; damaged DNA binding; ATP binding; single-stranded DNA-dependent ATPase activity; single-stranded DNA binding
Biological Process: DNA unwinding during replication; meiosis; mitotic recombination; DNA recombinase assembly; meiotic recombination; double-strand break repair; positive regulation of DNA ligation; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination; protein homooligomerization; DNA recombination
Disease: Breast Cancer; Mirror Movements 2
Research Articles on RAD51
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Products associated with anti-RAD51 antibody
Pathways associated with anti-RAD51 antibody
Diseases associated with anti-RAD51 antibody
Organs/Tissues associated with anti-RAD51 antibody
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