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anti-RAD51 antibody :: anti-Human, Mouse RAD51A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8242715
Unit / Price
0.03 mL  /  $165 +1 FREE 8GB USB
0.1 mL  /  $245 +1 FREE 8GB USB
0.2 mL  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAD51A, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-RAD51A (pY315) Antibody

 Product Synonym Names    RAD51A; RECA; DNA repair protein RAD51 homolog 1; HsRAD51; hRAD51; RAD51 homolog A
 Product Gene Name   

anti-RAD51 antibody

[Similar Products]
 Antibody/Peptide Pairs    RAD51A peptide (MBS8243598) is used for blocking the activity of RAD51A antibody (MBS8242715)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114480
 3D Structure    ModBase 3D Structure for Q06609
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 Clonality    Polyclonal
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes endogenous levels of RAD51A (pY315) protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
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 Source    Rabbit
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human RAD51A. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-RAD51 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RAD51 antibody

   Rabbit polyclonal antibody to RAD51A (pY315)
 Applications Tested/Suitable for anti-RAD51 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-RAD51 antibody    Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200)
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 Western Blot (WB) of anti-RAD51 antibody    Western blot analysis of RAD51A (pY315) expression in HeLa UV-treated (A), HEK293T UV-treated (B) whole cell lysates.
anti-RAD51 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RAD51 antibody    Immunohistochemical analysis of RAD51A (pY315) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-RAD51 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RAD51. It may not necessarily be applicable to this product.
 NCBI GI #    548663
 NCBI GeneID    5888
 NCBI Accession #    Q06609.1 [Other Products]
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 UniProt Primary Accession #    Q06609 [Other Products]
 UniProt Secondary Accession #    Q6FHX9; Q6ZNA8; Q9BV60; B0FXP0; B2R8T6 [Other Products]
 UniProt Related Accession #    Q06609 [Other Products]
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 NCBI Official Full Name    DNA repair protein RAD51 homolog 1
 NCBI Official Synonym Full Names    RAD51 recombinase
 NCBI Official Symbol    RAD51 [Similar Products]
 NCBI Official Synonym Symbols   
RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
[Similar Products]
 NCBI Protein Information    DNA repair protein RAD51 homolog 1
 UniProt Protein Name    DNA repair protein RAD51 homolog 1
 UniProt Synonym Protein Names   
RAD51 homolog A
 Protein Family    DNA repair protein
 UniProt Gene Name    RAD51 [Similar Products]
 UniProt Synonym Gene Names    RAD51A; RECA; HsRAD51; hRAD51 [Similar Products]
 UniProt Entry Name    RAD51_HUMAN
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 NCBI Summary for RAD51    The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
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 UniProt Comments for RAD51    Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).
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 Research Articles on RAD51    1. Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-RAD51 antibodyDiseases associated with anti-RAD51 antibody
 Products by Pathway  Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway antibodies  HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway Diagram
 HDR Through Homologous Recombination (HRR) Pathway antibodies  HDR Through Homologous Recombination (HRR) Pathway Diagram
 HDR Through Single Strand Annealing (SSA) Pathway antibodies  HDR Through Single Strand Annealing (SSA) Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >326 publications with RAD51 and Breast Neoplasms
 Genetic Predisposition to Disease Antibodies  >165 publications with RAD51 and Genetic Predisposition to Disease
 Anemia Antibodies  >162 publications with RAD51 and Anemia
 Ovarian Neoplasms Antibodies  >116 publications with RAD51 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >76 publications with RAD51 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >67 publications with RAD51 and Lung Neoplasms
 Adenocarcinoma Antibodies  >65 publications with RAD51 and Adenocarcinoma
 Lung Diseases Antibodies  >58 publications with RAD51 and Lung Diseases
 Head and Neck Neoplasms Antibodies  >56 publications with RAD51 and Head and Neck Neoplasms
 Carcinoma, Squamous Cell Antibodies  >43 publications with RAD51 and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-RAD51 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >140 publications with RAD51 and Blood
 Lung Antibodies  >100 publications with RAD51 and Lung
 Testis Antibodies  >62 publications with RAD51 and Testis
 Brain Antibodies  >52 publications with RAD51 and Brain
 Ovary Antibodies  >47 publications with RAD51 and Ovary
 Bone Antibodies  >46 publications with RAD51 and Bone
 Prostate Antibodies  >41 publications with RAD51 and Prostate
 Bone Marrow Antibodies  >41 publications with RAD51 and Bone Marrow
 Skin Antibodies  >33 publications with RAD51 and Skin
 Liver Antibodies  >27 publications with RAD51 and Liver
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