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anti-RAD51C antibody :: Rabbit anti-Human RAD51C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9125331
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAD51C, Polyclonal Antibody

 Also Known As   

RAD51C Polyclonal Antibody

 Product Synonym Names    FANCO; R51H3; BROVCA3; RAD51L2
 Product Gene Name   

anti-RAD51C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 613399
 3D Structure    ModBase 3D Structure for O43502
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human RAD51C
 Calculated Molecular Weight    42kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-RAD51C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-RAD51C antibody

   This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants.
 Product Categories/Family for anti-RAD51C antibody    Polyclonal
 Applications Tested/Suitable for anti-RAD51C antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-RAD51C antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:100
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 Western Blot (WB) of anti-RAD51C antibody    Western blot analysis of extracts of various cell lines, using RAD51C antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
anti-RAD51C antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RAD51C antibody    Immunohistochemistry of paraffin-embedded human prostate using RAD51C antibody at dilution of 1:100 (40x lens).
anti-RAD51C antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-RAD51C antibody    Immunohistochemistry of paraffin-embedded human stomach using RAD51C antibody at dilution of 1:100 (40x lens).
anti-RAD51C antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-RAD51C antibody    Immunohistochemistry of paraffin-embedded mouse stomach using RAD51C antibody at dilution of 1:100 (40x lens).
anti-RAD51C antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RAD51C. It may not necessarily be applicable to this product.
 NCBI GI #    3914534
 NCBI GeneID    5889
 NCBI Accession #    O43502.1 [Other Products]
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 UniProt Primary Accession #    O43502 [Other Products]
 UniProt Secondary Accession #    O43503; Q3B783 [Other Products]
 UniProt Related Accession #    O43502 [Other Products]
 Molecular Weight    376
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 NCBI Official Full Name    DNA repair protein RAD51 homolog 3
 NCBI Official Synonym Full Names    RAD51 paralog C
 NCBI Official Symbol    RAD51C [Similar Products]
 NCBI Official Synonym Symbols   
FANCO; R51H3; BROVCA3; RAD51L2
[Similar Products]
 NCBI Protein Information    DNA repair protein RAD51 homolog 3; RAD51-like protein 2; yeast RAD51 homolog 3
 UniProt Protein Name    DNA repair protein RAD51 homolog 3
 UniProt Synonym Protein Names   
RAD51 homolog C; RAD51-like protein 2
 Protein Family    DNA repair protein
 UniProt Gene Name    RAD51C [Similar Products]
 UniProt Synonym Gene Names    RAD51L2; R51H3 [Similar Products]
 UniProt Entry Name    RA51C_HUMAN
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 NCBI Summary for RAD51C    This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for RAD51C    RAD51C: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. Defects in RAD51C are the cause of Fanconi anemia complementation group O (FANCO). It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Defects in RAD51C are the cause of familial breast- ovarian cancer type 3 (BROVCA3). It is a condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. Belongs to the RecA family. RAD51 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: nucleoplasm; mitochondrion; perinuclear region of cytoplasm; cytoplasm; replication fork; nucleus

Molecular Function: DNA-dependent ATPase activity; protein binding; DNA binding; four-way junction DNA binding; crossover junction endodeoxyribonuclease activity; ATP binding

Biological Process: male meiosis I; meiotic recombination; sister chromatid cohesion; spermatogenesis; female meiosis sister chromatid cohesion; DNA repair; blood coagulation; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; DNA recombination

Disease: Tracheoesophageal Fistula With Or Without Esophageal Atresia; Breast-ovarian Cancer, Familial, Susceptibility To, 3; Fanconi Anemia, Complementation Group O
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 Research Articles on RAD51C    1. three different cancer susceptibility and FA proteins function in a DNA repair pathway based upon the PALB2 WD40 domain binding to RAD51C and BRCA2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RAD51C antibodyPathways associated with anti-RAD51C antibody
 Reference Product  PubMed Publications
 XRCC3 antibody  >68 publications with RAD51C and XRCC3
 BRCA2 antibody  >56 publications with RAD51C and BRCA2
 BRCA1 antibody  >46 publications with RAD51C and BRCA1
 RAD51L3 antibody  >17 publications with RAD51C and RAD51L3
 RAD50 antibody  >9 publications with RAD51C and RAD50
 RAD51L1 antibody  >7 publications with RAD51C and RAD51L1
 MRE11A antibody  >4 publications with RAD51C and MRE11A
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Recombination Pathway antibodies  Meiotic Recombination Pathway Diagram
Diseases associated with anti-RAD51C antibodyOrgans/Tissues associated with anti-RAD51C antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >53 publications with RAD51C and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >42 publications with RAD51C and Ovarian Neoplasms
 Fanconi Anemia Antibodies  >27 publications with RAD51C and Fanconi Anemia
 Anemia Antibodies  >27 publications with RAD51C and Anemia
 Neoplasms, Experimental Antibodies  >6 publications with RAD51C and Neoplasms, Experimental
 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 Antibodies  >4 publications with RAD51C and BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
 Cell Transformation, Neoplastic Antibodies  >4 publications with RAD51C and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >3 publications with RAD51C and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >3 publications with RAD51C and Carcinoma, Squamous Cell
 Prostatic Neoplasms Antibodies  >2 publications with RAD51C and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with RAD51C and Blood
 Ovary Antibodies  >7 publications with RAD51C and Ovary
 Testis Antibodies  >6 publications with RAD51C and Testis
 Prostate Antibodies  >4 publications with RAD51C and Prostate
 Bone Marrow Antibodies  >3 publications with RAD51C and Bone Marrow
 Bone Antibodies  >3 publications with RAD51C and Bone
 Muscle Antibodies  >2 publications with RAD51C and Muscle
 Liver Antibodies  >2 publications with RAD51C and Liver
 Eye Antibodies  >2 publications with RAD51C and Eye
 Heart Antibodies  >2 publications with RAD51C and Heart
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