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anti-RANBP10 antibody :: Rabbit anti-Human RANBP10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151209
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RANBP10, Polyclonal Antibody

 Also Known As   

RANBP10 Antibody

 Product Synonym Names    RANBP10; KIAA1464; Ran-binding protein 10; RanBP10; RAN binding protein 10
 Product Gene Name   

anti-RANBP10 antibody

[Similar Products]
 Antibody/Peptide Pairs    RANBP10 peptide (MBS153270) is used for blocking the activity of RANBP10 antibody (MBS151209)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614031
 3D Structure    ModBase 3D Structure for Q6VN20
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    RANBP10 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    RANBP10 antibody was raised against a 15 amino acid synthetic peptide near the center of human RANBP10.
 Buffer    RANBP10 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    RANBP10 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-RANBP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-RANBP10 antibody

   RANBP10 Antibody: The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.
 Applications Tested/Suitable for anti-RANBP10 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-RANBP10 antibody    RANBP10 antibody can be used for detection of RANBP10 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-RANBP10 antibody    Western blot analysis of RANBP10 in human skeletal muscle tissue lysate with RANBP10 antibody at (A) 1 and (B) 2 μg/mL.
anti-RANBP10 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-RANBP10 antibody    Immunofluorescence of RANBP10 in mouse skeletal muscle tissue with RANBP10 antibody at 20 μg/mL.
anti-RANBP10 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-RANBP10 antibody    Immunohistochemistry of RANBP10 in human skeletal muscle tissue with RANBP10 antibody at 5 μg/mL.
anti-RANBP10 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RANBP10. It may not necessarily be applicable to this product.
 NCBI GI #    119603573
 NCBI GeneID    57610
 NCBI Accession #    EAW83167 [Other Products]
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 UniProt Primary Accession #    Q6VN20 [Other Products]
 UniProt Secondary Accession #    Q9P264; A4FTY2; B4DID0; B4DQH9; E7EW27 [Other Products]
 UniProt Related Accession #    Q6VN20 [Other Products]
 Molecular Weight    64,542 Da
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 NCBI Official Full Name    RAN binding protein 10, isoform CRA_a
 NCBI Official Synonym Full Names    RAN binding protein 10
 NCBI Official Symbol    RANBP10 [Similar Products]
 NCBI Protein Information    ran-binding protein 10
 UniProt Protein Name    Ran-binding protein 10
 Protein Family    Ran-binding protein
 UniProt Gene Name    RANBP10 [Similar Products]
 UniProt Synonym Gene Names    KIAA1464; RanBP10 [Similar Products]
 UniProt Entry Name    RBP10_HUMAN
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 UniProt Comments for RANBP10    RANBP10: Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function. May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway. Belongs to the RANBP9/10 family.

Protein type: GEFs; GEFs, Ras; GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasmic microtubule; cytosol; nucleus

Molecular Function: Ran guanyl-nucleotide exchange factor activity; beta-tubulin binding; Ran GTPase binding

Biological Process: microtubule cytoskeleton organization and biogenesis
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 Research Articles on RANBP10    1. data support the idea that RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1) receptor signaling by PKCdelta and PKCgamma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RANBP10 antibodyPathways associated with anti-RANBP10 antibody
 Reference Product  PubMed Publications
 RANBP9 antibody  >4 publications with RANBP10 and RANBP9
 MET antibody  >2 publications with RANBP10 and MET
 Products by Pathway  Pathway Diagram
 Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway antibodies  Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway Diagram
Diseases associated with anti-RANBP10 antibodyOrgans/Tissues associated with anti-RANBP10 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >1 publications with RANBP10 and Immune System Diseases
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1 publications with RANBP10 and Nerve
 Liver Antibodies  >1 publications with RANBP10 and Liver
 Kidney Antibodies  >1 publications with RANBP10 and Kidney
 Prostate Antibodies  >1 publications with RANBP10 and Prostate
 Embryonic Tissue Antibodies  >1 publications with RANBP10 and Embryonic Tissue
 Uterus Antibodies  >1 publications with RANBP10 and Uterus
 Brain Antibodies  >1 publications with RANBP10 and Brain
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