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anti-TNFRSF11A antibody :: Rabbit anti-Human RANK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175230
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RANK (TNFRSF11A), Polyclonal Antibody

 Also Known As   

Anti-RANK antibody

 Product Synonym Names    Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator; Activator of NFKB antibody; CD 265 antibody; CD265 antibody; CD265 antigen antibody; EOF antibody; FEO antibody; LOH18CR1 antibody; Loss of heterozygosity 18 chromosomal region 1 antibody; mRANK antibody; NFKB activator antibody; ODFR antibody; OFE antibody; OPTB7 antibody; Osteoclast differentiation factor receptor antibody; OSTS antibody; PDB 2 antibody; PDB2 antibody; RANK antibody; Receptor activator of NF KB antibody; Receptor activator of NF-KB antibody; receptor activator of nuclear factor kappa B antibody; TNFRSF 11A antibody; TNFRSF11A antibody; TNFSF11 antibody; TNR11_HUMAN antibody; TRANCE R antibody; TRANCER antibody; Tumor necrosis factor receptor superfamily member 11a NFKB activator antibody; Tumor necrosis factor receptor superfamily member 11a activator of NFKB antibody; Tumor Necrosis Factor Receptor Superfamily Member 11a antibody
 Product Gene Name   

anti-TNFRSF11A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612301
 3D Structure    ModBase 3D Structure for Q9Y6Q6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human RANK (29-44aa QIAPPCTSEKHYEHLG).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TNFRSF11A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TNFRSF11A antibody

   Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 11A(TNFRSF11A) detection. Tested with WB, IHC-P in Human.
Background: Receptor Activator of Nuclear Factor K B(RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. RANKL(Receptor Activator for Nuclear Factor K B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al.(1997) mapped the RANK gene to 18q22.1.
 Applications Tested/Suitable for anti-TNFRSF11A antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Western Blot (WB) of anti-TNFRSF11A antibody    Anti-RANK antibody, MBS175230, Western blotting
Lane 1: Recombinant Human RANK Protein 10ng
Lane 2: Recombinant Human RANK Protein 5ng
Lane 3: Recombinant Human RANK Protein 2.5ng
anti-TNFRSF11A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TNFRSF11A antibody    Anti-RANK antibody, MBS175230, IHC(P)
IHC(P): Human Mammary Cancer Tissue
anti-TNFRSF11A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TNFRSF11A. It may not necessarily be applicable to this product.
 NCBI GI #    19924309
 NCBI GeneID    8792
 NCBI Accession #    Q9Y6Q6.1 [Other Products]
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 UniProt Primary Accession #    Q9Y6Q6 [Other Products]
 UniProt Secondary Accession #    Q59EP9; I4EC36; I4EC38; I4EC39; I7JE63; N0GVH0 [Other Products]
 UniProt Related Accession #    Q9Y6Q6 [Other Products]
 Molecular Weight    64,552 Da
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 NCBI Official Full Name    Tumor necrosis factor receptor superfamily member 11A
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 11a, NFKB activator
 NCBI Official Symbol    TNFRSF11A [Similar Products]
 NCBI Official Synonym Symbols   
FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 11A; Paget disease of bone 2; receptor activator of NF-KB; osteoclast differentiation factor receptor; receptor activator of nuclear factor-kappa B; loss of heterozygosity, 18, chromosomal region 1
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 11A
 UniProt Synonym Protein Names   
Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD_antigen: CD265
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF11A [Similar Products]
 UniProt Synonym Gene Names    RANK; ODFR [Similar Products]
 UniProt Entry Name    TNR11_HUMAN
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 NCBI Summary for TNFRSF11A    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
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 UniProt Comments for TNFRSF11A    TNFRSF11A: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.1

Cellular Component: integral to membrane; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; tumor necrosis factor receptor activity; metal ion binding; cytokine binding; receptor activity

Biological Process: circadian thermoregulation; positive regulation of JNK activity; ossification; adaptive immune response; response to lipopolysaccharide; osteoclast differentiation; signal transduction; lymph node development; activation of NF-kappaB transcription factor; monocyte chemotaxis; response to radiation; cell-cell signaling; tumor necrosis factor-mediated signaling pathway; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of transcription factor activity

Disease: Osteopetrosis, Autosomal Recessive 7; Familial Expansile Osteolysis; Paget Disease Of Bone
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 Research Articles on TNFRSF11A    1. Mechanistic studies showed that IL-10 downregulated RANK expression in monocytes and thus, inhibited RANKL-induced OC formation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFRSF11A antibodyPathways associated with anti-TNFRSF11A antibody
 Reference Product  PubMed Publications
 TNFSF11 antibody  >1523 publications with TNFRSF11A and TNFSF11
 TRAF6 antibody  >62 publications with TNFRSF11A and TRAF6
 TRAF2 antibody  >15 publications with TNFRSF11A and TRAF2
 TRAF1 antibody  >8 publications with TNFRSF11A and TRAF1
 TRAF5 antibody  >8 publications with TNFRSF11A and TRAF5
 TRAF3 antibody  >6 publications with TNFRSF11A and TRAF3
 TEC antibody  >4 publications with TNFRSF11A and TEC
 VEGFA antibody  >3 publications with TNFRSF11A and VEGFA
 BTK antibody  >1 publications with TNFRSF11A and BTK
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 RANKL/RANK Signaling Pathway antibodies  RANKL/RANK Signaling Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
Diseases associated with anti-TNFRSF11A antibodyOrgans/Tissues associated with anti-TNFRSF11A antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >879 publications with TNFRSF11A and Necrosis
 Inflammation Antibodies  >143 publications with TNFRSF11A and Inflammation
 Cardiovascular Diseases Antibodies  >108 publications with TNFRSF11A and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >93 publications with TNFRSF11A and Disease Models, Animal
 Breast Neoplasms Antibodies  >55 publications with TNFRSF11A and Breast Neoplasms
 Osteitis Deformans Antibodies  >48 publications with TNFRSF11A and Osteitis Deformans
 Neoplasm Metastasis Antibodies  >38 publications with TNFRSF11A and Neoplasm Metastasis
 Osteosarcoma Antibodies  >28 publications with TNFRSF11A and Osteosarcoma
 Kidney Diseases Antibodies  >21 publications with TNFRSF11A and Kidney Diseases
 Neoplasms, Experimental Antibodies  >19 publications with TNFRSF11A and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1348 publications with TNFRSF11A and Bone
 Vascular Antibodies  >75 publications with TNFRSF11A and Vascular
 Brain Antibodies  >21 publications with TNFRSF11A and Brain
 Liver Antibodies  >20 publications with TNFRSF11A and Liver
 Skin Antibodies  >19 publications with TNFRSF11A and Skin
 Embryonic Tissue Antibodies  >19 publications with TNFRSF11A and Embryonic Tissue
 Heart Antibodies  >19 publications with TNFRSF11A and Heart
 Lung Antibodies  >18 publications with TNFRSF11A and Lung
 Kidney Antibodies  >18 publications with TNFRSF11A and Kidney
 Intestine Antibodies  >8 publications with TNFRSF11A and Intestine
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