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anti-RANKL antibody :: Rabbit RANKL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2537469
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RANKL, Polyclonal Antibody

★Popular Item★
 Also Known As   

RANKL Polyclonal Antibody

 Product Synonym Names    TNFSF11; OPGL; RANKL; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL
 Product Gene Name   

anti-RANKL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    259710
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the C-terminal region of human RANKL.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.1436% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RANKL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RANKL antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-RANKL antibody    WB: 1:500-1:2000, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-RANKL antibody    Western Blot analysis of 293T cells with RANKL Polyclonal Antibody.
anti-RANKL antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RANKL antibody    Immunohistochemistry of paraffin-embedded Human lung tissue using RANKL Polyclonal Antibody at dilution of 1:100.
anti-RANKL antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RANKL. It may not necessarily be applicable to this product.
 NCBI GI #    2612922
 NCBI GeneID    8600
 NCBI Accession #    AAB86811.1 [Other Products]
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 UniProt Secondary Accession #    O14723; Q96Q17; Q9P2Q3 [Other Products]
 UniProt Related Accession #    O14788 [Other Products]
 Molecular Weight    Calculated MW: 35
Observed MW: 35
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 NCBI Official Full Name    RANKL
 NCBI Official Synonym Full Names    tumor necrosis factor superfamily member 11
 NCBI Official Symbol    TNFSF11 [Similar Products]
 NCBI Official Synonym Symbols   
ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 11
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 11
 UniProt Synonym Protein Names   
Osteoclast differentiation factor; ODF
 UniProt Gene Name    TNFSF11 [Similar Products]
 UniProt Synonym Gene Names    OPGL; RANKL; TRANCE; ODF; OPGL; RANKL; TRANCE [Similar Products]
 UniProt Entry Name    TNF11_HUMAN
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 NCBI Summary for RANKL    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RANKL    TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: cytoplasm; extracellular region; extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; bone resorption; calcium ion homeostasis; cytokine and chemokine mediated signaling pathway; immune response; mammary gland epithelial cell proliferation; monocyte chemotaxis; organ morphogenesis; ossification; osteoclast differentiation; positive regulation of bone resorption; positive regulation of corticotropin-releasing hormone secretion; positive regulation of homotypic cell-cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of osteoclast differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of T cell activation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein homooligomerization; tumor necrosis factor-mediated signaling pathway

Disease: Osteopetrosis, Autosomal Recessive 2
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 Research Articles on RANKL    1. These findings suggest that RACK1 specifies the RANKL-stimulated activation of p38 MAPK by facilitating the association of MKK6 with TAK1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RANKL antibodyPathways associated with anti-RANKL antibody
 Reference Product  PubMed Publications
 TNFRSF11A antibody  >1483 publications with RANKL and TNFRSF11A
 TNFRSF11B antibody  >880 publications with RANKL and TNFRSF11B
 PTH antibody  >120 publications with RANKL and PTH
 FOS antibody  >116 publications with RANKL and FOS
 TRAF6 antibody  >87 publications with RANKL and TRAF6
 CTSK antibody  >83 publications with RANKL and CTSK
 SRC antibody  >59 publications with RANKL and SRC
 SOST antibody  >31 publications with RANKL and SOST
 STAT3 antibody  >21 publications with RANKL and STAT3
 PTHLH antibody  >7 publications with RANKL and PTHLH
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with anti-RANKL antibodyOrgans/Tissues associated with anti-RANKL antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1031 publications with RANKL and Necrosis
 Osteoporosis Antibodies  >454 publications with RANKL and Osteoporosis
 Inflammation Antibodies  >248 publications with RANKL and Inflammation
 Osteolysis Antibodies  >191 publications with RANKL and Osteolysis
 Cardiovascular Diseases Antibodies  >165 publications with RANKL and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >92 publications with RANKL and Breast Neoplasms
 Osteopetrosis Antibodies  >87 publications with RANKL and Osteopetrosis
 Alveolar Bone Loss Antibodies  >55 publications with RANKL and Alveolar Bone Loss
 Neoplasm Metastasis Antibodies  >50 publications with RANKL and Neoplasm Metastasis
 Pain Antibodies  >43 publications with RANKL and Pain
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >347 publications with RANKL and Connective Tissue
 Lymph Node Antibodies  >48 publications with RANKL and Lymph Node
 Liver Antibodies  >39 publications with RANKL and Liver
 Brain Antibodies  >29 publications with RANKL and Brain
 Pancreas Antibodies  >3 publications with RANKL and Pancreas
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