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anti-RARA antibody :: Rabbit anti-Human, mouse RARA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9212799
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RARA, Polyclonal Antibody

★Popular Item★
 Also Known As   

RARA Antibody (C-term)

 Product Synonym Names    Retinoic acid receptor alpha; RAR-alpha; Nuclear receptor subfamily 1 group B member 1; RARA; NR1B1
 Product Gene Name   

anti-RARA antibody

[Similar Products]
 Antibody/Peptide Pairs    RARA peptide (MBS9220242) is used for blocking the activity of RARA antibody (MBS9212799)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    322-349
 OMIM    180240
 3D Structure    ModBase 3D Structure for P10276
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Specificity    This RARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-349 amino acids from the C-terminal region of human RARA.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    0.31mg/ml (lot specific)
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 Antigen Type    Synthetic Peptide
 Crown Antibody    Yes
 Cellular Location    Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-RARA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RARA antibody

   Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand- dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
 Product Categories/Family for anti-RARA antibody    Crown Antibodies; Cancer; Signal Transduction
 Applications Tested/Suitable for anti-RARA antibody   

Immunofluorescence (IF), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Western Blot (WB)

 Application Notes for anti-RARA antibody    WB~~1:1000
IF~~1:10~50
IHC-P~~1:10~50
FC~~1:10~50
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 Western Blot (WB) of anti-RARA antibody    RARA Antibody (C-term) western blot analysis in HL-60 cell line and mouse testis tissue lysates (35ug/lane).This demonstrates the RARA antibody detected the RARA protein (arrow).
anti-RARA antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-RARA antibody    Confocal immunofluorescent analysis of RARA Antibody (C-term) with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
anti-RARA antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-RARA antibody    RARA Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RARA Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-RARA antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-RARA antibody    RARA Antibody (C-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-RARA antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for RARA. It may not necessarily be applicable to this product.
 NCBI GI #    4506419
 NCBI GeneID    5914
 NCBI Accession #    NP_000955.1 [Other Products]
 NCBI Related Accession #    NP_001019980.1; NP_001138773.1; NP_001138774.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000964.3 [Other Products]
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 UniProt Primary Accession #    P10276 [Other Products]
 UniProt Secondary Accession #    P78456; Q13440; Q13441; Q96S41; Q9NQS0; B8Y636 [Other Products]
 UniProt Related Accession #    P10276 [Other Products]
 Molecular Weight    50771
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 NCBI Official Full Name    retinoic acid receptor alpha isoform 1
 NCBI Official Synonym Full Names    retinoic acid receptor, alpha
 NCBI Official Symbol    RARA [Similar Products]
 NCBI Official Synonym Symbols   
RAR; NR1B1
[Similar Products]
 NCBI Protein Information    retinoic acid receptor alpha
 UniProt Protein Name    Retinoic acid receptor alpha
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group B member 1
 Protein Family    Retinoic acid receptor
 UniProt Gene Name    RARA [Similar Products]
 UniProt Synonym Gene Names    NR1B1; RAR-alpha [Similar Products]
 UniProt Entry Name    RARA_HUMAN
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 NCBI Summary for RARA    This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
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 UniProt Comments for RARA    RARA: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Oncoprotein; Transcription factor; Nuclear receptor

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; cell surface; cell soma; perinuclear region of cytoplasm; nuclear chromatin; dendrite; cytoplasm; nucleus; actin cytoskeleton

Molecular Function: protein domain specific binding; protein kinase B binding; retinoic acid binding; zinc ion binding; chromatin DNA binding; transcription coactivator activity; translation repressor activity, nucleic acid binding; drug binding; phosphoinositide 3-kinase regulator activity; alpha-actinin binding; transcription factor binding; protein binding; enzyme binding; protein heterodimerization activity; protein kinase A binding; steroid hormone receptor activity; mRNA 5'-UTR binding; retinoic acid receptor activity; transcription factor activity; transcription corepressor activity; receptor binding

Biological Process: prostate gland development; negative regulation of translational initiation; estrogen receptor signaling pathway; regulation of myelination; glandular epithelial cell development; positive regulation of transcription, DNA-dependent; regulation of synaptic plasticity; female pregnancy; regulation of phosphoinositide 3-kinase activity; protein amino acid phosphorylation; response to vitamin A; germ cell development; Sertoli cell fate commitment; positive regulation of T-helper 2 cell differentiation; positive regulation of cell cycle; positive regulation of phosphoinositide 3-kinase cascade; response to ethanol; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; limb development; retinoic acid receptor signaling pathway; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to estradiol stimulus; negative regulation of granulocyte differentiation; positive regulation of interleukin-4 production; negative regulation of cell proliferation; ureteric bud development; negative regulation of interferon-gamma production; positive regulation of cell proliferation; positive regulation of interleukin-13 production; transmembrane transport; positive regulation of interleukin-5 production; transcription initiation from RNA polymerase II promoter; response to retinoic acid; multicellular organism growth; negative regulation of tumor necrosis factor production; positive regulation of binding; liver development; embryonic camera-type eye development; positive regulation of protein kinase B signaling cascade; response to cytokine stimulus; neural tube closure; gene expression; spermatogenesis; positive regulation of neuron differentiation; apoptotic cell clearance

Disease: Acute Promyelocytic Leukemia
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Product References and Citations for anti-RARA antibody

   Park, U.H., et al. J. Biol. Chem. 285(44):34269-34278(2010)
Asleson, A.D., et al. Cancer Genet. Cytogenet. 202(1):33-37(2010)
Catalano, A., et al. Blood 110(12):4073-4076(2007)
Wells, R.A., et al. Nat. Genet. 17(1):109-113(1997)
Chen, Z., et al. Proc. Natl. Acad. Sci. U.S.A. 91(3):1178-1182(1994)
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 Research Articles on RARA    1. This study identifies a novel mechanism through which NPM-RAR affects leukemogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RARA antibodyPathways associated with anti-RARA antibody
 Reference Product  PubMed Publications
 PML antibody  >446 publications with RARA and PML
 MED1 antibody  >2 publications with RARA and MED1
 RXRG antibody  >1 publications with RARA and RXRG
 NCOA3 antibody  >1 publications with RARA and NCOA3
 NCOR1 antibody  >1 publications with RARA and NCOR1
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Diseases associated with anti-RARA antibodyOrgans/Tissues associated with anti-RARA antibody
 Disease Name  Pubmed Publications
 Leukemia, Promyelocytic, Acute Antibodies  >400 publications with RARA and Leukemia, Promyelocytic, Acute
 Kidney Diseases Antibodies  >124 publications with RARA and Kidney Diseases
 Proteinuria Antibodies  >80 publications with RARA and Proteinuria
 Disease Models, Animal Antibodies  >42 publications with RARA and Disease Models, Animal
 Breast Neoplasms Antibodies  >25 publications with RARA and Breast Neoplasms
 Nervous System Diseases Antibodies  >17 publications with RARA and Nervous System Diseases
 Adenocarcinoma Antibodies  >12 publications with RARA and Adenocarcinoma
 Neoplasms, Second Primary Antibodies  >11 publications with RARA and Neoplasms, Second Primary
 Neoplasms, Experimental Antibodies  >11 publications with RARA and Neoplasms, Experimental
 Necrosis Antibodies  >9 publications with RARA and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >225 publications with RARA and Blood
 Kidney Antibodies  >195 publications with RARA and Kidney
 Bone Antibodies  >153 publications with RARA and Bone
 Bone Marrow Antibodies  >142 publications with RARA and Bone Marrow
 Vascular Antibodies  >51 publications with RARA and Vascular
 Skin Antibodies  >27 publications with RARA and Skin
 Liver Antibodies  >26 publications with RARA and Liver
 Brain Antibodies  >22 publications with RARA and Brain
 Embryonic Tissue Antibodies  >21 publications with RARA and Embryonic Tissue
 Lung Antibodies  >18 publications with RARA and Lung
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