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anti-RASA4 antibody :: Rabbit anti-Human, Mouse RASA4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9610121
Western Blot (WB)
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RASA4, Polyclonal Antibody

★Popular Item★
 Also Known As   

RASA4 Antibody

 Product Synonym Names    Ca2+ promoted Ras inactivator; Calcium promoted Ras inactivator; CAPRI; GAPL; GTPase activating protein like; KIAA0538; MGC131890; Ras GTPase activating protein 4; RAS p21 protein activator 4; RasGAP activating like protein 2
 Product Gene Name   

anti-RASA4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O43374
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    RASA4 antibody detects endogenous levels of total RASA4
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide derived from human RASA4
 Subcellular Location    Cytoplasm; Cytosol. Cell Membrane; Peripheral Membrane Protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
 Tissue Specificity    Widely expressed.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-RASA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RASA4 antibody

   Function: Ca2+-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
Similarity: The PH domain does not bind phosphatidylinositol 4, 5-bisphosphate or phosphatidylinositol 3, 4, 5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
 Applications Tested/Suitable for anti-RASA4 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-RASA4 antibody    WB: 1:1000-3000
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 Western Blot (WB) of anti-RASA4 antibody    Western blot analysis of RASA4 using RAW264.7 whole cell lysates
anti-RASA4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for RASA4. It may not necessarily be applicable to this product.
 NCBI GI #    299829175
 NCBI GeneID    10156
 NCBI Accession #    NP_001073346.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079877.2 [Other Products]
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 UniProt Primary Accession #    O43374 [Other Products]
 UniProt Secondary Accession #    O60286; Q14CQ4; Q86UW3; Q96QU0 [Other Products]
 UniProt Related Accession #    O43374 [Other Products]
 Molecular Weight    Observed: 90 kDa
Predicted: 91 kDa
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 NCBI Official Full Name    ras GTPase-activating protein 4 isoform 2
 NCBI Official Synonym Full Names    RAS p21 protein activator 4
 NCBI Official Symbol    RASA4 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    ras GTPase-activating protein 4
 UniProt Protein Name    Ras GTPase-activating protein 4
 UniProt Synonym Protein Names   
Calcium-promoted Ras inactivator; Ras p21 protein activator 4; RasGAP-activating-like protein 2
 Protein Family    Ras GTPase-activating protein
 UniProt Gene Name    RASA4 [Similar Products]
 UniProt Synonym Gene Names    CAPRI; GAPL; KIAA0538 [Similar Products]
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 NCBI Summary for RASA4    This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RASA4    Ca2+-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
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 Research Articles on RASA4    1. RASA4 isoform 2 promoter methylation correlated with clinical parameters predicting poor prognosis (older age, elevated fetal hemoglobin), with higher risk of relapse after hematopoietic stem cell transplantation, and with PTPN11 mutation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RASA4 antibodyPathways associated with anti-RASA4 antibody
 Reference Product  PubMed Publications
 RASGRP1 antibody  >2 publications with RASA4 and RASGRP1
 Products by Pathway  Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
Diseases associated with anti-RASA4 antibodyOrgans/Tissues associated with anti-RASA4 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with RASA4 and Breast Neoplasms
 Uterine Neoplasms Antibodies  >1 publications with RASA4 and Uterine Neoplasms
 Adenocarcinoma Antibodies  >1 publications with RASA4 and Adenocarcinoma
 Endometrial Neoplasms Antibodies  >1 publications with RASA4 and Endometrial Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with RASA4 and Bone
 Blood Antibodies  >2 publications with RASA4 and Blood
 Brain Antibodies  >2 publications with RASA4 and Brain
 Uterus Antibodies  >1 publications with RASA4 and Uterus
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