AAI44408.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,953 Da
NCBI Official Full Name
RBM25 protein
NCBI Official Synonym Full Names
RNA binding motif protein 25
NCBI Official Synonym Symbols
S164; NET52; RNPC7; Snu71; RED120; fSAP94 [Similar Products]
NCBI Protein Information
RNA-binding protein 25
UniProt Protein Name
RNA-binding protein 25
UniProt Synonym Protein Names
Arg/Glu/Asp-rich protein of 120 kDa; RED120; Protein S164; RNA-binding motif protein 25; RNA-binding region-containing protein 7
UniProt Synonym Gene Names
UniProt Entry Name
RBM25_HUMAN
UniProt Comments for RBM25
RBM25: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA splicing; Spliceosome; RNA-binding
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: cytoplasm; nuclear speck; nucleoplasm; spliceosome
Molecular Function: mRNA binding; nucleotide binding; protein binding
Biological Process: mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of apoptosis; RNA splicing
Research Articles on RBM25
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Pathways associated with anti-RBM25 antibody
Diseases associated with anti-RBM25 antibody
Organs/Tissues associated with anti-RBM25 antibody
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