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anti-RBM38 antibody :: Rabbit RBM38 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2527405
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RBM38, Polyclonal Antibody

★Popular Item★
 Also Known As   

RBM38 Polyclonal Antibody

 Product Synonym Names    RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2
 Product Gene Name   

anti-RBM38 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612428
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    2.3mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human RBM38
 Calculated Molecular Weight: 25kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RBM38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RBM38 antibody

   RBM38 (RNA-binding protein 38), also known as RNPC1 or SEB4. RBM38 is a cell cycle protein found in the cytosol and the Nucleus that exists as two alternatively spliced isoforms, 1 (RNPC1a) and 2 (RNPC1b), of 239 and 121 amino acids, respectively. Independent of p53 expression, RBM38 isoform 1 induces cell cycle arrest in G1 phase through maintaining transcript stability at the 3'-UTR of p21, a regulator of cell cycle progression at S phase. RBM38 is also an mRNA splicing factor that regulates the expression of FGFR2. RBM38 contains one RRM (RNA recognition motif) domain.
 Product Categories/Family for anti-RBM38 antibody    Stem cells; Cell biology
 Applications Tested/Suitable for anti-RBM38 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-RBM38 antibody    WB: 1:200-1:1000
IHC: 1:25-1:100
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 Western Blot (WB) of anti-RBM38 antibody    Western Blot analysis of Human heart tissue using RBM38 Polyclonal Antibody at dilution of 1:200
anti-RBM38 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RBM38 antibody    Immunohistochemistry of paraffin-embedded Human liver cancer using RBM38 Polyclonal Antibody at dilution of 1:35
anti-RBM38 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-RBM38 antibody    Immunohistochemistry of paraffin-embedded Human esophagus cancer using RBM38 Polyclonal Antibody at dilution of 1:35
anti-RBM38 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RBM38. It may not necessarily be applicable to this product.
 NCBI GI #    619534169
 NCBI GeneID    55544
 NCBI Accession #    NP_001278709.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291780.1 [Other Products]
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 UniProt Secondary Accession #    Q15350; Q15351; Q9BYK3; Q9BYK4; A6NDK1; A6NMU6 [Other Products]
 UniProt Related Accession #    Q9H0Z9 [Other Products]
 Molecular Weight    12,914 Da
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 NCBI Official Full Name    RNA-binding protein 38 isoform c
 NCBI Official Synonym Full Names    RNA binding motif protein 38
 NCBI Official Symbol    RBM38 [Similar Products]
 NCBI Official Synonym Symbols   
RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2
[Similar Products]
 NCBI Protein Information    RNA-binding protein 38; CLL-associated antigen KW-5; RNA-binding region (RNP1, RRM) containing 1; RNA-binding region-containing protein 1; ssDNA-binding protein SEB4
 UniProt Protein Name    RNA-binding protein 38
 UniProt Synonym Protein Names   
CLL-associated antigen KW-5; HSRNASEB; RNA-binding motif protein 38; RNA-binding region-containing protein 1; ssDNA-binding protein SEB4
 Protein Family    RNA-binding protein
 UniProt Gene Name    RBM38 [Similar Products]
 UniProt Synonym Gene Names    RNPC1; SEB4 [Similar Products]
 UniProt Entry Name    RBM38_HUMAN
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 UniProt Comments for RBM38    RBM38: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. Belongs to the RBM38 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: nucleoplasm; cytosol; nucleus

Molecular Function: mRNA binding; mRNA 3'-UTR binding; nucleotide binding

Biological Process: negative regulation of cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of RNA splicing; RNA splicing; cell cycle arrest; cell cycle; cell differentiation; mRNA processing; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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 Research Articles on RBM38    1. RBM38 as novel transcriptional target of E2F1 restricts E2F1-induced proliferation. Furthermore, this negative feedback loop seems to restrict tumor aggressiveness, thereby promoting survival of patients with cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RBM38 antibodyDiseases associated with anti-RBM38 antibody
 Reference Product  PubMed Publications
 TP63 antibody  >1 publications with RBM38 and TP63
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with RBM38 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with RBM38 and Ovarian Neoplasms
 Liver Diseases Antibodies  >1 publications with RBM38 and Liver Diseases
 Neural Tube Defects Antibodies  >1 publications with RBM38 and Neural Tube Defects
 Congenital Abnormalities Antibodies  >1 publications with RBM38 and Congenital Abnormalities
 Carcinoma, Hepatocellular Antibodies  >1 publications with RBM38 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with RBM38 and Liver Neoplasms
Organs/Tissues associated with anti-RBM38 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with RBM38 and Muscle
 Liver Antibodies  >1 publications with RBM38 and Liver
 Heart Antibodies  >1 publications with RBM38 and Heart
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