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anti-RBP4 antibody :: Goat RBP4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421164
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RBP4, Polyclonal Antibody

 Also Known As   

Goat anti-RBP4 Antibody

 Product Synonym Names    Goat Anti-RBP4 (Internal) Antibody; RBP4; retinol binding protein 4, plasma; retinol-binding protein 4, interstitial; retinol-binding protein 4, plasma; RBP4 antibody; retinol binding protein 4; plasma antibody; retinol-binding protein 4; interstitial antibody; retinol-binding protein 4; plasma antibody
 Product Gene Name   

anti-RBP4 antibody

[Similar Products]
 Antibody/Peptide Pairs    RBP4 peptide (MBS428122) is used for blocking the activity of RBP4 antibody (MBS421164)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QKGNDDHWIV DTDYD
 OMIM    180250
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QKGNDDHWIVDTDYD, from the internal region of the protein sequence according to NP_006735.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-RBP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RBP4 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-RBP4 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 22kDa band observed in human liver and skin lysates (calculated MW of 23. 0kDa according to NP_006735.2). Recommended concentration: 0.3-1ug/ml.
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 Western Blot (WB) of anti-RBP4 antibody    (0.3ug/ml) staining of human skin lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-RBP4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for RBP4. It may not necessarily be applicable to this product.
 NCBI GI #    55743122
 NCBI GeneID    5950
 NCBI Accession #    NP_006735.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006744.3 [Other Products]
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 UniProt Secondary Accession #    O43478; O43479; Q5VY24; Q8WWA3; Q9P178; D3DR38 [Other Products]
 UniProt Related Accession #    P02753 [Other Products]
 Molecular Weight    23,010 Da
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 NCBI Official Full Name    retinol-binding protein 4 isoform a
 NCBI Official Synonym Full Names    retinol binding protein 4
 NCBI Official Symbol    RBP4 [Similar Products]
 NCBI Official Synonym Symbols   
RDCCAS; MCOPCB10
[Similar Products]
 NCBI Protein Information    retinol-binding protein 4
 UniProt Protein Name    Retinol-binding protein 4
 UniProt Synonym Protein Names   
Plasma retinol-binding protein; PRBP; RBP
 Protein Family    Retinol-binding protein
 UniProt Gene Name    RBP4 [Similar Products]
 UniProt Synonym Gene Names    PRBP; RBP [Similar Products]
 UniProt Entry Name    RET4_HUMAN
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 NCBI Summary for RBP4    This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RBP4    RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: cytosol; extracellular region; extracellular space; protein complex

Molecular Function: protein binding; protein heterodimerization activity; retinal binding; retinol binding

Biological Process: cardiac muscle development; embryonic organ morphogenesis; embryonic retina morphogenesis in camera-type eye; embryonic skeletal development; eye development; female genitalia morphogenesis; gluconeogenesis; glucose homeostasis; heart development; lung development; maintenance of gastrointestinal epithelium; negative regulation of cardiac muscle cell proliferation; positive regulation of immunoglobulin secretion; positive regulation of insulin secretion; response to ethanol; response to retinoic acid; retinoid metabolic process; retinol metabolic process; urinary bladder development; uterus development; vagina development; visual perception

Disease: Microphthalmia, Isolated, With Coloboma 10; Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome
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 Research Articles on RBP4    1. Genetic variants of retinol-binding protein 4 in adolescents are associated with liver function and inflammatory markers but not with obesity and insulin resistance
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RBP4 antibodyPathways associated with anti-RBP4 antibody
 Reference Product  PubMed Publications
 TTR antibody  >42 publications with RBP4 and TTR
 STRA6 antibody  >27 publications with RBP4 and STRA6
 ALB antibody  >4 publications with RBP4 and ALB
 RBP1 antibody  >4 publications with RBP4 and RBP1
 BCMO1 antibody  >2 publications with RBP4 and BCMO1
 ORM1 antibody  >1 publications with RBP4 and ORM1
 BCO2 antibody  >1 publications with RBP4 and BCO2
 RPE65 antibody  >1 publications with RBP4 and RPE65
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Retinoid Cycle Disease Events Pathway antibodies  Retinoid Cycle Disease Events Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Retinoid Metabolism Disease Events Pathway antibodies  Retinoid Metabolism Disease Events Pathway Diagram
 SREBP Signalling Pathway antibodies  SREBP Signalling Pathway Diagram
Diseases associated with anti-RBP4 antibodyOrgans/Tissues associated with anti-RBP4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >103 publications with RBP4 and Inflammation
 Liver Diseases Antibodies  >77 publications with RBP4 and Liver Diseases
 Fatty Liver Antibodies  >68 publications with RBP4 and Fatty Liver
 Necrosis Antibodies  >57 publications with RBP4 and Necrosis
 Hyperglycemia Antibodies  >50 publications with RBP4 and Hyperglycemia
 Kidney Diseases Antibodies  >39 publications with RBP4 and Kidney Diseases
 Glucose Intolerance Antibodies  >38 publications with RBP4 and Glucose Intolerance
 Polycystic Ovary Syndrome Antibodies  >27 publications with RBP4 and Polycystic Ovary Syndrome
 Weight Loss Antibodies  >25 publications with RBP4 and Weight Loss
 Disease Models, Animal Antibodies  >22 publications with RBP4 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >172 publications with RBP4 and Liver
 Connective Tissue Antibodies  >122 publications with RBP4 and Connective Tissue
 Muscle Antibodies  >65 publications with RBP4 and Muscle
 Kidney Antibodies  >44 publications with RBP4 and Kidney
 Heart Antibodies  >35 publications with RBP4 and Heart
 Brain Antibodies  >19 publications with RBP4 and Brain
 Bone Antibodies  >18 publications with RBP4 and Bone
 Pancreas Antibodies  >16 publications with RBP4 and Pancreas
 Eye Antibodies  >15 publications with RBP4 and Eye
 Embryonic Tissue Antibodies  >12 publications with RBP4 and Embryonic Tissue
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