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anti-Rcan2 antibody :: Rabbit RCAN2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151578
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RCAN2, Polyclonal Antibody

 Also Known As   

RCAN2 Antibody

 Product Synonym Names    RCAN2; Csp2; MCIP2; ZAKI-4; Dscr1l1; Zaki4; Calcipressin-2; Calcineurin inhibitory protein ZAKI-4; regulator of calcineurin 2
 Product Gene Name   

anti-Rcan2 antibody

[Similar Products]
 Antibody/Peptide Pairs    RCAN2 peptide (MBS152156) is used for blocking the activity of RCAN2 antibody (MBS151578)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9JHG2
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    RCAN2 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    RCAN2 antibody was raised against a 14 amino acid synthetic peptide near the center of human RCAN2.
 Buffer    RCAN2 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    RCAN2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-Rcan2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Rcan2 antibody

   RCAN2 Antibody: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
 Applications Tested/Suitable for anti-Rcan2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-Rcan2 antibody    RCAN2 antibody can be used for detection of RCAN2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-Rcan2 antibody    Western blot analysis of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 μg/mL.
anti-Rcan2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-Rcan2 antibody    Immunohistochemistry of RCAN2 in mouse brain tissue with RCAN2 antibody at 2.5 μg/mL.
anti-Rcan2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-Rcan2 antibody    Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 μg/mL.
anti-Rcan2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for Rcan2. It may not necessarily be applicable to this product.
 NCBI GI #    38328420
 NCBI GeneID    53901
 NCBI Accession #    AAH62141 [Other Products]
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 UniProt Primary Accession #    Q9JHG2 [Other Products]
 UniProt Secondary Accession #    Q8VIP5 [Other Products]
 UniProt Related Accession #    Q9JHG2 [Other Products]
 Molecular Weight    22,025 Da
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 NCBI Official Full Name    Rcan2 protein
 NCBI Official Synonym Full Names    regulator of calcineurin 2
 NCBI Official Symbol    Rcan2 [Similar Products]
 NCBI Official Synonym Symbols   
Csp2; MCIP2; ZAKI-4; Dscr1l1
[Similar Products]
 NCBI Protein Information    calcipressin-2; calcineurin inhibitory protein ZAKI-4; Down syndrome critical region gene 1-like 1; down syndrome candidate region 1-like protein 1; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2
 UniProt Protein Name    Calcipressin-2
 UniProt Synonym Protein Names   
Calcineurin inhibitory protein ZAKI-4; Down syndrome candidate region 1-like protein 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2
 Protein Family    Calcipressin
 UniProt Gene Name    Rcan2 [Similar Products]
 UniProt Synonym Gene Names    Dscr1l1; Zaki4; MCIP2 [Similar Products]
 UniProt Entry Name    RCAN2_MOUSE
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 UniProt Comments for Rcan2    RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: intracellular

Molecular Function: nucleotide binding

Biological Process: calcineurin-NFAT signaling pathway; short-term memory; calcium-mediated signaling; response to stress; response to oxidative stress; locomotion during locomotory behavior
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 Research Articles on Rcan2    1. Rcan2 regulates osteoblast function and its expression in bone is regulated by thyroid status in vivo
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Rcan2 antibodyDiseases associated with anti-Rcan2 antibody
 Products by Pathway  Pathway Diagram
 Thyroid Hormone Signaling Pathway antibodies  Thyroid Hormone Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with Rcan2 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >4 publications with Rcan2 and Congenital Abnormalities
 Hypertrophy Antibodies  >3 publications with Rcan2 and Hypertrophy
 Atrophy Antibodies  >2 publications with Rcan2 and Atrophy
 Inflammation Antibodies  >2 publications with Rcan2 and Inflammation
 Brain Diseases Antibodies  >1 publications with Rcan2 and Brain Diseases
 Heart Diseases Antibodies  >1 publications with Rcan2 and Heart Diseases
 Weight Gain Antibodies  >1 publications with Rcan2 and Weight Gain
 Disease Models, Animal Antibodies  >1 publications with Rcan2 and Disease Models, Animal
 Learning Disorders Antibodies  >1 publications with Rcan2 and Learning Disorders
Organs/Tissues associated with anti-Rcan2 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >20 publications with Rcan2 and Muscle
 Brain Antibodies  >7 publications with Rcan2 and Brain
 Heart Antibodies  >5 publications with Rcan2 and Heart
 Kidney Antibodies  >3 publications with Rcan2 and Kidney
 Spinal Cord Antibodies  >3 publications with Rcan2 and Spinal Cord
 Liver Antibodies  >2 publications with Rcan2 and Liver
 Thymus Antibodies  >1 publications with Rcan2 and Thymus
 Pancreas Antibodies  >1 publications with Rcan2 and Pancreas
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