P18754
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
regulator of chromosome condensation 1
NCBI Official Synonym Full Names
regulator of chromosome condensation 1
NCBI Protein Information
regulator of chromosome condensation; OTTHUMP00000003775; OTTHUMP00000003777; OTTHUMP00000211004; OTTHUMP00000211005; OTTHUMP00000211007; OTTHUMP00000211009; cell cycle regulatory protein; SNHG3-RCC1 readthrough transcript; guanine nucleotide-releasing protein
UniProt Protein Name
Regulator of chromosome condensation
UniProt Synonym Protein Names
Cell cycle regulatory protein; Chromosome condensation protein 1
UniProt Synonym Gene Names
UniProt Entry Name
RCC1_HUMAN
UniProt Comments for RCC1
RCC1: a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP for GTP. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; GEFs, Ras; GEFs
Chromosomal Location of Human Ortholog: 1p36.1
Cellular Component: nucleoplasm; nuclear membrane; condensed nuclear chromosome; nuclear chromatin; cytoplasm; nucleus
Molecular Function: protein binding; nucleosomal DNA binding; histone binding; Ran guanyl-nucleotide exchange factor activity; chromatin binding
Biological Process: mitosis; mitotic spindle organization and biogenesis; viral reproduction; cell division; regulation of mitosis; spindle assembly; chromosome segregation; G1/S transition of mitotic cell cycle
Research Articles on RCC1
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Products associated with anti-RCC1 antibody
Pathways associated with anti-RCC1 antibody
Diseases associated with anti-RCC1 antibody
Organs/Tissues associated with anti-RCC1 antibody
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