Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow RELA rightarrow Polyclonal RELA  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Fibroblast Growth Factor 21 (FGF-21) ELISA Kit
 • 12-Lipoxygenase (LOX-12) ELISA Kit
 • Growth Hormone (GH) ELISA Kit
 • M13 BACTERIOPHAGE Antibody
 • HMOX2 Antibody
 • sema domain, immunoglobulin domain (Ig) , transmembrane doma... ELISA Kit
 • Dipeptidylpeptidase 4 (DPP4) Antibody
 • integrin, alpha 4 (ITGA4) Antibody
 • Immunoglobulin G4 (IgG4) ELISA Kit
 • serine-threonine kinase 4 (STK4) ELISA Kit
 • CD29 Antibody
 • S100B Antibody
 • LRP1 - CD91 Antibody
 • Tissue Inhibitors of Metalloproteinase 4 (TIMP-4) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-RELA antibody :: Rabbit RELA / NFKB p65 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241394
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RELA / NFKB p65, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human RELA / NFKB p65

 Product Synonym Names    Anti-RELA / NFKB p65 Antibody (Ser536) IHC-plus; RELA; NF-kappa-B p65delta3; NFKB3; p65; Transcription factor p65; Human RELA; NFKB p65
 Product Gene Name   

anti-RELA antibody

[Similar Products]
 Product Synonym Gene Name    NFKB [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    164014
 3D Structure    ModBase 3D Structure for Q04206
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    Amino acids surrounding Ser 536 of human RELA (NF-KB p65)
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol.
 Concentration    1 mg/ml (lot specific)
Section Bar
 Target Species    Human
 Immunogen Description    Synthetic peptide from human RELA.
 Immunogen Type    Synthetic peptide
 Immunogen    RELA / NFKB p65 antibody was raised against synthetic peptide from human RELA.
 Antigen Modification    Ser536
Section Bar
 Preparation and Storage    Long term: -20 degree C; Short term: -20 degree C
 Other Notes    Small volumes of anti-RELA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-RELA antibody

   NFKB1 or NFKB2 bind to REL, RELA, or RELB to form the NFKB complex. The NFKB1/RELA heterodimer is the most abundant form of NFKB. The NFKB complex is inactivated by I-kappa-B proteins that keep it trapped in the cytoplasm. Phosphorylation of serine residues on the I-kappa B proteins mark them for ubiquitination and destruction, and NFKB translocates to the nucleus where it binds DNA.
 Applications Tested/Suitable for anti-RELA antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-RELA antibody    IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Section Bar
 Immunohistochemistry (IHC) of anti-RELA antibody    Anti-RELA antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-RELA antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Western Blot (WB) of anti-RELA antibody    Western blot of extracts from HeLa and 293 cells using NFkB-p65(Ab-536) antibody.
anti-RELA antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for RELA. It may not necessarily be applicable to this product.
 NCBI GI #    223468676
 NCBI GeneID    5970
 NCBI Accession #    NP_068810.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_021975.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q04206 [Other Products]
 UniProt Secondary Accession #    Q6GTV1; Q6SLK1 [Other Products]
 UniProt Related Accession #    Q04206 [Other Products]
 Molecular Weight    59,910 Da
Table BarTOPTable Bar
 NCBI Official Full Name    transcription factor p65 isoform 1
 NCBI Official Synonym Full Names    v-rel avian reticuloendotheliosis viral oncogene homolog A
 NCBI Official Symbol    RELA [Similar Products]
 NCBI Official Synonym Symbols   
p65; NFKB3
[Similar Products]
 NCBI Protein Information    transcription factor p65; NF-kappa-B p65delta3; nuclear factor NF-kappa-B p65 subunit; v-rel reticuloendotheliosis viral oncogene homolog A; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
 UniProt Protein Name    Transcription factor p65
 UniProt Synonym Protein Names   
Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
 Protein Family    Transcription factor
 UniProt Gene Name    RELA [Similar Products]
 UniProt Synonym Gene Names    NFKB3 [Similar Products]
 UniProt Entry Name    TF65_HUMAN
Section Bar
 NCBI Summary for RELA    NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Section Bar
 UniProt Comments for RELA    NFkB-p65: a subunit of NF-kappa-B transcription complex, which plays a crucial role in inflammatory and immune responses. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. P65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Three splice-variant isoforms have been identified.

Protein type: Nuclear receptor co-regulator; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus; cytosol

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; identical protein binding; transcription activator binding; protein N-terminus binding; protein kinase binding; transcription factor binding; NF-kappaB binding; protein binding; DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; protein complex binding; chromatin binding; phosphate binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; response to cAMP; viral reproduction; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; negative regulation of insulin receptor signaling pathway; response to morphine; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; response to insulin stimulus; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; response to organic substance; hair follicle development; positive regulation of cell proliferation; positive regulation of interferon type I production; inflammatory response; defense response to virus; toll-like receptor 4 signaling pathway; aging; response to drug; positive regulation of Schwann cell differentiation; membrane protein intracellular domain proteolysis; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; acetaldehyde metabolic process; liver development; response to amino acid stimulus; toll-like receptor 2 signaling pathway; response to UV-B; MyD88-dependent toll-like receptor signaling pathway; organ morphogenesis; positive regulation of interleukin-12 biosynthetic process; positive regulation of chondrocyte differentiation; response to muramyl dipeptide; response to mechanical stimulus; regulation of inflammatory response; toll-like receptor signaling pathway; innate immune response; cellular defense response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of protein catabolic process; response to cobalamin; negative regulation of apoptosis
Table BarTOPTable Bar
 Research Articles on RELA    1. The nuclear expression of NF-kappaB p65 is increased in the eutopic endometrium and ovarian endometrioma of women with advanced stage endometriosis, which strongly suggests that NF-small ka, CyrillicB signaling plays a crucial role in the pathophysiology of endometriosis.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-RELA antibodyPathways associated with anti-RELA antibody
 Reference Product  PubMed Publications
 IKBKB antibody  >521 publications with RELA and IKBKB
 CHUK antibody  >157 publications with RELA and CHUK
 NFKB1 antibody  >116 publications with RELA and NFKB1
 HDAC1 antibody  >38 publications with RELA and HDAC1
 CREBBP antibody  >34 publications with RELA and CREBBP
 EP300 antibody  >29 publications with RELA and EP300
 NFKBIA antibody  >17 publications with RELA and NFKBIA
 COMMD1 antibody  >14 publications with RELA and COMMD1
 NFKBIB antibody  >4 publications with RELA and NFKBIB
 UBC antibody  >3 publications with RELA and UBC
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
Diseases associated with anti-RELA antibodyOrgans/Tissues associated with anti-RELA antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1579 publications with RELA and Necrosis
 Inflammation Antibodies  >1341 publications with RELA and Inflammation
 Liver Diseases Antibodies  >292 publications with RELA and Liver Diseases
 Nervous System Diseases Antibodies  >238 publications with RELA and Nervous System Diseases
 Breast Neoplasms Antibodies  >130 publications with RELA and Breast Neoplasms
 Kidney Diseases Antibodies  >126 publications with RELA and Kidney Diseases
 Neoplasms, Experimental Antibodies  >116 publications with RELA and Neoplasms, Experimental
 Fibrosis Antibodies  >104 publications with RELA and Fibrosis
 Cell Transformation, Neoplastic Antibodies  >103 publications with RELA and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >93 publications with RELA and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1165 publications with RELA and Blood
 Liver Antibodies  >577 publications with RELA and Liver
 Vascular Antibodies  >552 publications with RELA and Vascular
 Lung Antibodies  >435 publications with RELA and Lung
 Muscle Antibodies  >302 publications with RELA and Muscle
 Brain Antibodies  >302 publications with RELA and Brain
 Bone Antibodies  >235 publications with RELA and Bone
 Kidney Antibodies  >210 publications with RELA and Kidney
 Heart Antibodies  >190 publications with RELA and Heart
 Intestine Antibodies  >186 publications with RELA and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions