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anti-REN antibody :: Rabbit anti-Human, Mouse REN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7049591
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

REN, Polyclonal Antibody

★Popular Item★
 Also Known As   

REN Antibody

 Product Synonym Names    Renin; Angiotensinogenase; REN
 Product Gene Name   

anti-REN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    L00073
 3D Structure
   ModBase 3D Structure for P00797
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Renin protein (229-398AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27318 / sc-22752
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-REN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-REN antibody

   Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
 Applications Tested/Suitable for anti-REN antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-REN antibody    WB: 1: 2000-1: 5000
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-REN antibody    Western Blot
Positive WB detected in:Mouse heart tissue,Mouse spleen tissue,Mouse lung tissue,Mouse stomach tissue
All lanes: REN antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46,45 kDa
Observed band size: 46,29 kDa

anti-REN antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-REN antibody    Immunofluorescent analysis of HepG2 cells using MBS7049591 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-REN antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for REN. It may not necessarily be applicable to this product.
 NCBI GI #    4506475
 NCBI GeneID    5972
 NCBI Accession #    NP_000528.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000537.3 [Other Products]
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 UniProt Primary Accession #    P00797 [Other Products]
 UniProt Secondary Accession #    Q6FI38; Q6T5C2 [Other Products]
 UniProt Related Accession #    P00797 [Other Products]
 Molecular Weight    44,726 Da
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 NCBI Official Full Name    renin preproprotein
 NCBI Official Synonym Full Names    renin
 NCBI Official Symbol    REN [Similar Products]
 NCBI Official Synonym Symbols   
HNFJ2
[Similar Products]
 NCBI Protein Information    renin
 UniProt Protein Name    Renin
 UniProt Synonym Protein Names   
Angiotensinogenase
 Protein Family    Renin
 UniProt Gene Name    REN [Similar Products]
 UniProt Entry Name    RENI_HUMAN
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 NCBI Summary for REN    Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for REN    REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.15; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular region; extracellular space; lysosome; plasma membrane

Molecular Function: aspartic-type endopeptidase activity; peptidase activity; receptor binding

Biological Process: angiotensin maturation; kidney development; protein catabolic process; proteolysis; regulation of blood pressure; regulation of MAPKKK cascade

Disease: Hyperuricemic Nephropathy, Familial Juvenile, 2; Renal Tubular Dysgenesis
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 Research Articles on REN    1. Data show that the optimum time for beta-adrenoreceptor antagonists (beta-blockers) withdrawal was 2 weeks when using direct renin concentration (DRC) and 3 weeks for plasma renin activity (PRA).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-REN antibodyPathways associated with anti-REN antibody
 Reference Product  PubMed Publications
 ACE antibody  >181 publications with REN and ACE
 AGT antibody  >75 publications with REN and AGT
 INS antibody  >46 publications with REN and INS
 ACE2 antibody  >26 publications with REN and ACE2
 MME antibody  >10 publications with REN and MME
 ATP6AP2 antibody  >6 publications with REN and ATP6AP2
 KNG1 antibody  >4 publications with REN and KNG1
 CMA1 antibody  >3 publications with REN and CMA1
 CTSG antibody  >2 publications with REN and CTSG
 EDN1 antibody  >1 publications with REN and EDN1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin Secretion Pathway antibodies  Renin Secretion Pathway Diagram
 Renin Secretion Pathway antibodies  Renin Secretion Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with anti-REN antibodyOrgans/Tissues associated with anti-REN antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >5142 publications with REN and Kidney Diseases
 Renal Insufficiency Antibodies  >3422 publications with REN and Renal Insufficiency
 Hypertension Antibodies  >1512 publications with REN and Hypertension
 Heart Diseases Antibodies  >1480 publications with REN and Heart Diseases
 Necrosis Antibodies  >1216 publications with REN and Necrosis
 Acute Kidney Injury Antibodies  >1027 publications with REN and Acute Kidney Injury
 Pain Antibodies  >857 publications with REN and Pain
 Ischemia Antibodies  >855 publications with REN and Ischemia
 Fibrosis Antibodies  >708 publications with REN and Fibrosis
 Myocardial Ischemia Antibodies  >689 publications with REN and Myocardial Ischemia
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >6461 publications with REN and Kidney
 Lung Antibodies  >1644 publications with REN and Lung
 Skin Antibodies  >687 publications with REN and Skin
 Intestine Antibodies  >530 publications with REN and Intestine
 Embryonic Tissue Antibodies  >310 publications with REN and Embryonic Tissue
 Pancreas Antibodies  >218 publications with REN and Pancreas
 Bladder Antibodies  >199 publications with REN and Bladder
 Ovary Antibodies  >177 publications with REN and Ovary
 Testis Antibodies  >174 publications with REN and Testis
 Placenta Antibodies  >115 publications with REN and Placenta
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