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anti-UPF1 antibody :: Rabbit anti-Human RENT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS623606 anti-UPF1 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RENT1 (UPF1), Polyclonal Antibody

 Also Known As   

RENT1, NT (Regulator of Nonsense Transcripts 1, ATP-dependent Helicase RENT1, Nonsense mRNA Reducing Factor 1, NORF1, Up-frameshift Suppressor 1 Homolog, hUpf1, KIAA0221, UPF1)

 Product Synonym Names    Anti -RENT1, NT (Regulator of Nonsense Transcripts 1, ATP-dependent Helicase RENT1, Nonsense mRNA Reducing Factor 1, NORF1, Up-frameshift Suppressor 1 Homolog, hUpf1, KIAA0221, UPF1)
 Product Gene Name   

anti-UPF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (18942744..18979039). Location: 19p13.2-p13.11
 OMIM    601430
 3D Structure    ModBase 3D Structure for Q92900
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human RENT1.
 Purity/Purification    Purified
Purified by ammonium sulfate precipitation.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    KLH conjugated synthetic peptide between aa 304~334 in the N-terminal region of human RENT1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-UPF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-UPF1 antibody

   RENT1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
 Product Categories/Family for anti-UPF1 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-UPF1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-UPF1 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
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NCBI/Uniprot data below describe general gene information for UPF1. It may not necessarily be applicable to this product.
 NCBI GI #    18375673
 NCBI GeneID    5976
 NCBI Accession #    NP_002902.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002911.3 [Other Products]
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 UniProt Primary Accession #    Q92900 [Other Products]
 UniProt Secondary Accession #    O00239; O43343; Q86Z25; Q92842 [Other Products]
 UniProt Related Accession #    Q92900 [Other Products]
 Molecular Weight    124,345 Da [Similar Products]
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 NCBI Official Full Name    regulator of nonsense transcripts 1
 NCBI Official Synonym Full Names    UPF1 regulator of nonsense transcripts homolog (yeast)
 NCBI Official Symbol    UPF1 [Similar Products]
 NCBI Official Synonym Symbols   
HUPF1; NORF1; RENT1; smg-2; pNORF1
[Similar Products]
 NCBI Protein Information    regulator of nonsense transcripts 1; delta helicase; UP Frameshift 1; yeast Upf1p homolog; ATP-dependent helicase RENT1; nonsense mRNA reducing factor 1; up-frameshift mutation 1 homolog; up-frameshift suppressor 1 homolog; smg-2 homolog, nonsense mediated mRNA decay factor
 UniProt Protein Name    Regulator of nonsense transcripts 1
 UniProt Synonym Protein Names   
ATP-dependent helicase RENT1; Nonsense mRNA reducing factor 1; NORF1; Up-frameshift suppressor 1 homolog
 Protein Family    Regulator of nonsense transcripts
 UniProt Gene Name    UPF1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0221; RENT1; NORF1; hUpf1 [Similar Products]
 UniProt Entry Name    RENT1_HUMAN
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 NCBI Summary for UPF1    This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for UPF1    RENT1: RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability. Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Associates with the SGM1C complex; is phosphorylated by the complex kinase component SGM1. Interacts with UPF2, UPF3A and UPF3B. Interacts with EST1A and SLBP. Interacts (when hyperphosphorylated) with PNRC2. Interacts with EIF2C1, EIF2C2 and GSPT2. Ubiquitous. Belongs to the DNA2/NAM7 helicase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.-; Hydrolase; RNA-binding; EC 3.6.4.-; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus; chromatin

Molecular Function: protein binding; DNA binding; zinc ion binding; RNA binding; chromatin binding; helicase activity; ATP-dependent RNA helicase activity; ATP binding

Biological Process: mRNA export from nucleus; dosage compensation, by inactivation of X chromosome; mRNA catabolic process, nonsense-mediated decay; gene expression; DNA repair; DNA replication; regulation of translational termination
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 Research Articles on UPF1    1. The SQ domain of the human Upf1 helicase, directly interacts with the helicase domain to impede ATP hydrolysis and RNA unwinding.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UPF1 antibodyPathways associated with anti-UPF1 antibody
 Reference Product  PubMed Publications
 UPF2 antibody  >103 publications with UPF1 and UPF2
 SMG1 antibody  >28 publications with UPF1 and SMG1
 SMG6 antibody  >22 publications with UPF1 and SMG6
 SMG5 antibody  >19 publications with UPF1 and SMG5
 SMG7 antibody  >18 publications with UPF1 and SMG7
 UPF3B antibody  >12 publications with UPF1 and UPF3B
 UPF3A antibody  >8 publications with UPF1 and UPF3A
 EIF4A3 antibody  >5 publications with UPF1 and EIF4A3
 ETF1 antibody  >5 publications with UPF1 and ETF1
 RBM8A antibody  >3 publications with UPF1 and RBM8A
 Products by Pathway  Pathway Diagram
 Exon Junction Complex (EJC) Pathway antibodies  Exon Junction Complex (EJC) Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Nonsense Mediated Decay Enhanced By The Exon Junction Complex Pathway antibodies  Nonsense Mediated Decay Enhanced By The Exon Junction Complex Pathway Diagram
 Nonsense Mediated Decay Independent Of The Exon Junction Complex Pathway antibodies  Nonsense Mediated Decay Independent Of The Exon Junction Complex Pathway Diagram
 Nonsense-Mediated Decay Pathway antibodies  Nonsense-Mediated Decay Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
Diseases associated with anti-UPF1 antibodyOrgans/Tissues associated with anti-UPF1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with UPF1 and Nervous System Diseases
 Neoplasms Antibodies  >7 publications with UPF1 and Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with UPF1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >3 publications with UPF1 and Heart Diseases
 Atrophy Antibodies  >3 publications with UPF1 and Atrophy
 Immune System Diseases Antibodies  >2 publications with UPF1 and Immune System Diseases
 Heart Defects, Congenital Antibodies  >2 publications with UPF1 and Heart Defects, Congenital
 Prostatic Diseases Antibodies  >1 publications with UPF1 and Prostatic Diseases
 Nervous System Malformations Antibodies  >1 publications with UPF1 and Nervous System Malformations
 Prostatic Neoplasms Antibodies  >1 publications with UPF1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with UPF1 and Blood
 Muscle Antibodies  >6 publications with UPF1 and Muscle
 Brain Antibodies  >5 publications with UPF1 and Brain
 Kidney Antibodies  >4 publications with UPF1 and Kidney
 Nerve Antibodies  >3 publications with UPF1 and Nerve
 Heart Antibodies  >3 publications with UPF1 and Heart
 Liver Antibodies  >2 publications with UPF1 and Liver
 Vascular Antibodies  >2 publications with UPF1 and Vascular
 Embryonic Tissue Antibodies  >2 publications with UPF1 and Embryonic Tissue
 Thymus Antibodies  >2 publications with UPF1 and Thymus
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