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anti-REST / NRSF antibody :: Rabbit REST / NRSF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS544698 anti-REST / NRSF antibody
Unit / Price
0.1 mg Biotin  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

REST / NRSF, Polyclonal Antibody

 Also Known As   

REST / NRSF Antibody BIOTIN-Conjugated

 Product Synonym Names    Neural Restrictive Silencer Factor; NRSF; RE1 silencing transcription factor; Repressor binding to the X2 box; REST; X2 box repressor; XBR antibody
 Product Gene Name   

anti-REST / NRSF antibody

[Similar Products]
 Matching Pairs    Antibody: REST / NRSF (MBS544698)
Positive Control: REST / NRSF (MBS543192)
 Antibody/Peptide Pairs    REST / NRSF peptide (MBS544364) is used for blocking the activity of REST / NRSF antibody (MBS544698)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600571
 3D Structure    ModBase 3D Structure for Q13127
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    BIOTIN-Conjugated
 Concentration    0.52-0.54 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 1000-1097 on human REST protein.
 Expression    Ubiquitous, expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovaries.
 Molecular Function    Repressor, Chromatin binding, Core promoter binding
 Structure    Interacts with SIN3A, SIN3B and RCOR1. Interacts with CDYL.
 Subcellular Location    Nucleus
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-REST / NRSF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-REST / NRSF antibody

   BIOTIN-Conjugated RE1-silencing transcription factor Antibody
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes.
 Applications Tested/Suitable for anti-REST / NRSF antibody   

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-REST / NRSF antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for REST / NRSF. It may not necessarily be applicable to this product.
 NCBI GI #    296452989
 NCBI GeneID    5978
 NCBI Accession #    Q13127.3 [Other Products]
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 UniProt Primary Accession #    Q13127 [Other Products]
 UniProt Secondary Accession #    Q12956; Q12957; Q13134; Q59ER1; Q8IWI3; A2RUE0; B9EGJ0 [Other Products]
 UniProt Related Accession #    Q13127 [Other Products]
 Molecular Weight    119,083 Da
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 NCBI Official Full Name    RE1-silencing transcription factor
 NCBI Official Synonym Full Names    RE1 silencing transcription factor
 NCBI Official Symbol    REST [Similar Products]
 NCBI Official Synonym Symbols   
WT6; XBR; NRSF
[Similar Products]
 NCBI Protein Information    RE1-silencing transcription factor
 UniProt Protein Name    RE1-silencing transcription factor
 UniProt Synonym Protein Names   
Neural-restrictive silencer factor; X2 box repressor
 UniProt Gene Name    REST [Similar Products]
 UniProt Synonym Gene Names    NRSF; XBR [Similar Products]
 UniProt Entry Name    REST_HUMAN
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 NCBI Summary for REST / NRSF    This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]
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 UniProt Comments for REST / NRSF    REST: a transcriptional repressor that binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells during embryonic development. Induced during ageing in human cortical and hippocampal neurons, where it represses genes that promote cell death and induces the expression of stress response genes. Protects neurons from amyloid beta- and oxidative stress-induced toxicity. The deletion of REST in the mouse brain induces age-related neurodegeneration. Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. REST activates DYRK1A transcription via a neuron-restricted silencer element in the DYRK1A promoter. Four isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: chromatin; cytosol; nucleoplasm; nucleus; transcriptional repressor complex

Molecular Function: chromatin binding; histone deacetylase activity; metal ion binding; outward rectifier potassium channel activity; protein binding; protein complex binding; transcription factor activity; transcription factor binding

Biological Process: hemopoietic progenitor cell differentiation; negative regulation of aldosterone biosynthetic process; negative regulation of calcium ion-dependent exocytosis; negative regulation of cell proliferation; negative regulation of insulin secretion; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter
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 Research Articles on REST / NRSF    1. TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFbeta signaling activation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-REST / NRSF antibodyPathways associated with anti-REST / NRSF antibody
 Reference Product  PubMed Publications
 BDNF antibody  >131 publications with REST / NRSF and BDNF
 UBC antibody  >83 publications with REST / NRSF and UBC
 RCOR1 antibody  >42 publications with REST / NRSF and RCOR1
 HDAC1 antibody  >40 publications with REST / NRSF and HDAC1
 SIN3A antibody  >18 publications with REST / NRSF and SIN3A
 SIN3B antibody  >5 publications with REST / NRSF and SIN3B
 SMARCA4 antibody  >5 publications with REST / NRSF and SMARCA4
 EHMT2 antibody  >2 publications with REST / NRSF and EHMT2
 BTRC antibody  >2 publications with REST / NRSF and BTRC
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HDACs Deacetylate Histones Pathway antibodies  HDACs Deacetylate Histones Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
Diseases associated with anti-REST / NRSF antibodyOrgans/Tissues associated with anti-REST / NRSF antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >6192 publications with REST / NRSF and Hypertension
 Brain Diseases Antibodies  >5515 publications with REST / NRSF and Brain Diseases
 Carcinoma Antibodies  >2781 publications with REST / NRSF and Carcinoma
 Congenital Abnormalities Antibodies  >2616 publications with REST / NRSF and Congenital Abnormalities
 Inflammation Antibodies  >1905 publications with REST / NRSF and Inflammation
 Kidney Diseases Antibodies  >1682 publications with REST / NRSF and Kidney Diseases
 Hypertrophy Antibodies  >1628 publications with REST / NRSF and Hypertrophy
 Liver Diseases Antibodies  >1554 publications with REST / NRSF and Liver Diseases
 Necrosis Antibodies  >1491 publications with REST / NRSF and Necrosis
 Hemorrhage Antibodies  >1482 publications with REST / NRSF and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >38625 publications with REST / NRSF and Blood
 Heart Antibodies  >27852 publications with REST / NRSF and Heart
 Muscle Antibodies  >18297 publications with REST / NRSF and Muscle
 Vascular Antibodies  >13174 publications with REST / NRSF and Vascular
 Brain Antibodies  >13023 publications with REST / NRSF and Brain
 Bone Antibodies  >6089 publications with REST / NRSF and Bone
 Nerve Antibodies  >5968 publications with REST / NRSF and Nerve
 Lung Antibodies  >5706 publications with REST / NRSF and Lung
 Skin Antibodies  >4042 publications with REST / NRSF and Skin
 Liver Antibodies  >3214 publications with REST / NRSF and Liver
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