NP_057400.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,649 Da
NCBI Official Full Name
DNA repair protein REV1 isoform 1
NCBI Official Synonym Full Names
REV1, DNA directed polymerase
NCBI Protein Information
DNA repair protein REV1
UniProt Protein Name
DNA repair protein REV1
UniProt Synonym Protein Names
Alpha integrin-binding protein 80; AIBP80; Rev1-like terminal deoxycytidyl transferase
UniProt Synonym Gene Names
UniProt Entry Name
REV1_HUMAN
NCBI Summary for REV1
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
UniProt Comments for REV1
REV1L: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Belongs to the DNA polymerase type-Y family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.7.7.-; DNA repair, damage
Chromosomal Location of Human Ortholog: 2q11.1-q11.2
Cellular Component: nucleoplasm
Molecular Function: damaged DNA binding; deoxycytidyl transferase activity; metal ion binding; protein binding
Biological Process: bypass DNA synthesis; DNA replication; error-prone postreplication DNA repair; response to UV
Research Articles on REV1
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Products associated with anti-REV1 antibody
Pathways associated with anti-REV1 antibody
Diseases associated with anti-REV1 antibody
Organs/Tissues associated with anti-REV1 antibody
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