NP_001034241
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
17,671 Da
NCBI Official Full Name
regulator of G-protein signaling 21
NCBI Official Synonym Full Names
regulator of G-protein signaling 21
NCBI Protein Information
regulator of G-protein signaling 21; regulator of G-protein signalling 21
UniProt Protein Name
Regulator of G-protein signaling 21
UniProt Synonym Gene Names
UniProt Entry Name
RGS21_HUMAN
NCBI Summary for RGS21
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
UniProt Comments for RGS21
RGS21: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Protein type: GAPs; GAPs, misc.
Chromosomal Location of Human Ortholog: 1q31.2
Cellular Component: cytoplasm; plasma membrane
Molecular Function: GTPase activator activity
Biological Process: positive regulation of GTPase activity
Research Articles on RGS21
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Pathways associated with anti-RGS21 antibody
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