NP_005604.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,452 Da
NCBI Official Full Name
regulator of G-protein signaling 4 isoform 2
NCBI Official Synonym Full Names
regulator of G-protein signaling 4
NCBI Official Synonym Symbols
NCBI Protein Information
regulator of G-protein signaling 4; schizophrenia disorder 9
UniProt Protein Name
Regulator of G-protein signaling 4
UniProt Synonym Gene Names
UniProt Entry Name
RGS4_HUMAN
NCBI Summary for RGS4
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for RGS4
RGS4: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, RGS; GAPs
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: protein complex; cytoplasm; plasma membrane; cytosol
Molecular Function: calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity
Biological Process: regulation of G-protein coupled receptor protein signaling pathway; inactivation of MAPK activity; positive regulation of GTPase activity
Disease: Schizophrenia 9
Research Articles on RGS4
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Products associated with anti-RGS4 antibody
Pathways associated with anti-RGS4 antibody
Diseases associated with anti-RGS4 antibody
Organs/Tissues associated with anti-RGS4 antibody
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