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anti-RHOH antibody :: Rabbit anti-Human RHOH Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7003127
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RHOH, Polyclonal Antibody

★Popular Item★
 Also Known As   

RHOH Antibody

 Product Synonym Names    Rho-related GTP-binding protein RhoH; GTP-binding protein TTF; Translocation three four protein; RHOH; ARHH; TTF
 Product Gene Name   

anti-RHOH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602037
 3D Structure    ModBase 3D Structure for Q15669
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Rho-related GTP-binding protein RhoH protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-20603
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RHOH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RHOH antibody

   Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells. Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.
 Applications Tested/Suitable for anti-RHOH antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-RHOH antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7003127 at dilution of 1:100
anti-RHOH antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-RHOH antibody    Immunofluorescent analysis of A549 cells using MBS7003127 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-RHOH antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for RHOH. It may not necessarily be applicable to this product.
 NCBI GI #    507834078
 NCBI GeneID    399
 NCBI Accession #    NP_001265288.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278359.1 [Other Products]
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 UniProt Primary Accession #    Q15669 [Other Products]
 UniProt Related Accession #    Q15669 [Other Products]
 Molecular Weight    21,331 Da
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 NCBI Official Full Name    rho-related GTP-binding protein RhoH
 NCBI Official Synonym Full Names    ras homolog family member H
 NCBI Official Symbol    RHOH [Similar Products]
 NCBI Official Synonym Symbols   
TTF; ARHH
[Similar Products]
 NCBI Protein Information    rho-related GTP-binding protein RhoH
 UniProt Protein Name    Rho-related GTP-binding protein RhoH
 UniProt Synonym Protein Names   
GTP-binding protein TTF; Translocation three four protein
 Protein Family    Rho-related GTP-binding protein
 UniProt Gene Name    RHOH [Similar Products]
 UniProt Synonym Gene Names    ARHH; TTF [Similar Products]
 UniProt Entry Name    RHOH_HUMAN
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 NCBI Summary for RHOH    The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]
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 UniProt Comments for RHOH    RHOH: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells. Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation t(3;4)(q27;p11) with BCL6. Belongs to the small GTPase superfamily. Rho family.

Protein type: G protein, monomeric; G protein, monomeric, Rho; G protein

Chromosomal Location of Human Ortholog: 4p13

Cellular Component: cytoplasm; cytosol; immunological synapse; plasma membrane

Molecular Function: GTP binding; GTPase inhibitor activity; kinase inhibitor activity; protein binding; Rho GTPase binding

Biological Process: mast cell activation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of phosphorylation; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell differentiation
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 Research Articles on RHOH    1. Mutations in hematopoiesis-specific Rho GTPases Rac2 and RhoH lead to a wide range of human blood disorders. (Review)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RHOH antibodyDiseases associated with anti-RHOH antibody
 Reference Product  PubMed Publications
 RHOA antibody  >7 publications with RHOH and RHOA
 VAV1 antibody  >2 publications with RHOH and VAV1
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >5 publications with RHOH and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >2 publications with RHOH and Heart Diseases
 Leukemia, Myeloid, Acute Antibodies  >2 publications with RHOH and Leukemia, Myeloid, Acute
 Liver Diseases Antibodies  >1 publications with RHOH and Liver Diseases
 Memory Disorders Antibodies  >1 publications with RHOH and Memory Disorders
 Neoplasms, Experimental Antibodies  >1 publications with RHOH and Neoplasms, Experimental
 Weight Loss Antibodies  >1 publications with RHOH and Weight Loss
 Disease Models, Animal Antibodies  >1 publications with RHOH and Disease Models, Animal
 Fibrosis Antibodies  >1 publications with RHOH and Fibrosis
 Nervous System Diseases Antibodies  >1 publications with RHOH and Nervous System Diseases
Organs/Tissues associated with anti-RHOH antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >43 publications with RHOH and Blood
 Bone Marrow Antibodies  >10 publications with RHOH and Bone Marrow
 Thymus Antibodies  >5 publications with RHOH and Thymus
 Spleen Antibodies  >4 publications with RHOH and Spleen
 Lymph Node Antibodies  >3 publications with RHOH and Lymph Node
 Lymph Antibodies  >2 publications with RHOH and Lymph
 Intestine Antibodies  >1 publications with RHOH and Intestine
 Lung Antibodies  >1 publications with RHOH and Lung
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