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anti-RIPK2 antibody :: Rabbit RICK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151211
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RICK (RIPK2), Polyclonal Antibody

★Popular Item★
 Also Known As   

RICK Antibody

 Product Synonym Names    RICK; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; UNQ277/PRO314/PRO34092; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; receptor-interacting serine-threonine kinase 2
 Product Gene Name   

anti-RIPK2 antibody

[Similar Products]
 Antibody/Peptide Pairs    RICK peptide (MBS152264) is used for blocking the activity of RICK antibody (MBS151211)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603455
 3D Structure    ModBase 3D Structure for O43353
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    RICK Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
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 Conjugate    Unconjugated
 Immunogen    RICK antibody was raised against a peptide corresponding to amino acids near the amino terminus of human RICK.
 Buffer    RICK Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    RICK antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-RIPK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RIPK2 antibody

   RICK Antibody: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-κB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1β. The messenger RNA of RICK is expressed in multiple human tissues.
 Applications Tested/Suitable for anti-RIPK2 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-RIPK2 antibody    RICK antibody can be used for detection of RICK by Western blot at 1 mug/mL. An approximately 60 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.
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 Western Blot (WB) of anti-RIPK2 antibody    Western blot analysis of RICK in A431 (A) and K562 (K) whole cell lysate with RICK antibody at 1:1000 dilution.
anti-RIPK2 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-RIPK2 antibody    Immunocytochemistry of RICK in A431 cells with RICK antibody at 10 μg/mL.
anti-RIPK2 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for RIPK2. It may not necessarily be applicable to this product.
 NCBI GI #    20455217
 NCBI GeneID    8767
 NCBI Accession #    O43353.2 [Other Products]
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 UniProt Primary Accession #    O43353 [Other Products]
 UniProt Secondary Accession #    Q6UWF0; B7Z748 [Other Products]
 UniProt Related Accession #    O43353 [Other Products]
 Molecular Weight    60 kDa
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 NCBI Official Full Name    Receptor-interacting serine/threonine-protein kinase 2
 NCBI Official Synonym Full Names    receptor-interacting serine-threonine kinase 2
 NCBI Official Symbol    RIPK2 [Similar Products]
 NCBI Official Synonym Symbols   
CCK; RICK; RIP2; CARD3; GIG30; CARDIAK
[Similar Products]
 NCBI Protein Information    receptor-interacting serine/threonine-protein kinase 2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor-interacting protein 2; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase
 UniProt Protein Name    Receptor-interacting serine/threonine-protein kinase 2
 UniProt Synonym Protein Names   
CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2 (EC:2.7.10.2)
 Protein Family    Receptor-interacting serine/threonine-protein kinase
 UniProt Gene Name    RIPK2 [Similar Products]
 UniProt Synonym Gene Names    CARDIAK; RICK; RIP2; CARD-containing IL-1 beta ICE-kinase; RIP-2 [Similar Products]
 UniProt Entry Name    RIPK2_HUMAN
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 NCBI Summary for RIPK2    This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RIPK2    RIPK2: a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB.

Protein type: EC 2.7.10.2; Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; TKL group; RIPK family

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: cytoskeleton; protein complex; cytoplasm; cytosol; vesicle

Molecular Function: protein serine/threonine kinase activity; protein binding; LIM domain binding; signal transducer activity; protein homodimerization activity; CARD domain binding; non-membrane spanning protein tyrosine kinase activity; ATP binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; activation of MAPK activity; positive regulation of apoptosis; positive regulation of interleukin-12 production; apoptosis; stress-activated MAPK cascade; positive regulation of JNK cascade; toll-like receptor 3 signaling pathway; signal transduction; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; T cell proliferation; toll-like receptor 5 signaling pathway; response to exogenous dsRNA; positive regulation of immature T cell proliferation; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon-beta production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of interferon-alpha production; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of peptidyl-serine phosphorylation; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; positive regulation of protein ubiquitination; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of alpha-beta T cell proliferation; toll-like receptor 9 signaling pathway; positive regulation of T-helper 1 cell differentiation; positive regulation of cytokine and chemokine mediated signaling pathway; negative regulation of apoptosis
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 Research Articles on RIPK2    1. NOD1 and RIP2 interact with bacterial peptidoglycan on endosomes to promote autophagy and inflammatory signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RIPK2 antibodyPathways associated with anti-RIPK2 antibody
 Reference Product  PubMed Publications
 NOD2 antibody  >107 publications with RIPK2 and NOD2
 NOD1 antibody  >68 publications with RIPK2 and NOD1
 TRAF6 antibody  >14 publications with RIPK2 and TRAF6
 XIAP antibody  >8 publications with RIPK2 and XIAP
 BCL10 antibody  >5 publications with RIPK2 and BCL10
 BIRC3 antibody  >5 publications with RIPK2 and BIRC3
 CARD6 antibody  >4 publications with RIPK2 and CARD6
 BIRC2 antibody  >3 publications with RIPK2 and BIRC2
 NGFR antibody  >1 publications with RIPK2 and NGFR
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
Diseases associated with anti-RIPK2 antibodyOrgans/Tissues associated with anti-RIPK2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >75 publications with RIPK2 and Inflammation
 Necrosis Antibodies  >56 publications with RIPK2 and Necrosis
 Disease Models, Animal Antibodies  >15 publications with RIPK2 and Disease Models, Animal
 Nervous System Diseases Antibodies  >11 publications with RIPK2 and Nervous System Diseases
 Liver Diseases Antibodies  >5 publications with RIPK2 and Liver Diseases
 Colitis, Ulcerative Antibodies  >5 publications with RIPK2 and Colitis, Ulcerative
 Heart Diseases Antibodies  >4 publications with RIPK2 and Heart Diseases
 Hepatitis Antibodies  >4 publications with RIPK2 and Hepatitis
 Carcinoma, Hepatocellular Antibodies  >3 publications with RIPK2 and Carcinoma, Hepatocellular
 Weight Gain Antibodies  >3 publications with RIPK2 and Weight Gain
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >45 publications with RIPK2 and Blood
 Intestine Antibodies  >20 publications with RIPK2 and Intestine
 Lung Antibodies  >14 publications with RIPK2 and Lung
 Bone Antibodies  >14 publications with RIPK2 and Bone
 Bone Marrow Antibodies  >13 publications with RIPK2 and Bone Marrow
 Brain Antibodies  >13 publications with RIPK2 and Brain
 Spleen Antibodies  >9 publications with RIPK2 and Spleen
 Heart Antibodies  >9 publications with RIPK2 and Heart
 Liver Antibodies  >9 publications with RIPK2 and Liver
 Vascular Antibodies  >8 publications with RIPK2 and Vascular
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