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anti-RICTOR antibody :: Goat RICTOR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421193
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RICTOR, Polyclonal Antibody

 Also Known As   

Goat anti-RICTOR Antibody

 Product Synonym Names    RICTOR; Rictor; KIAA1999; AVO3; MGC39830; likely ortholog of mouse TORC2-specific protein AVO3 (S. cerevisiae); rapamycin-insensitive companion of mTOR; mAVO3; pianissimo; DKFZp686B11164; RPTOR independent companion of MTOR, complex 2; PIA; mAVO3; TORC2-s; Rictor antibody; KIAA1999 antibody; AVO3 antibody; MGC39830 antibody; likely ortholog of mouse TORC2-specific protein AVO3 (S. cerevisiae) antibody; rapamycin-insensitive companion of mTOR antibody; mAVO3 antibody; pianissimo antibody; DKFZp686B11164 antibody; RICTOR antibody; RPTOR independent companion of MTOR; complex 2 antibody; PIA antibody; mAVO3 antibody; TORC2-specific protein AVO3 antibody
 Product Gene Name   

anti-RICTOR antibody

[Similar Products]
 Antibody/Peptide Pairs    RICTOR peptide (MBS426928) is used for blocking the activity of RICTOR antibody (MBS421193)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KQPIVDTSAE S
 OMIM    609022
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KQPIVDTSAES, from the C Terminus of the protein sequence according to NP_689969.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-RICTOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RICTOR antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-RICTOR antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Immunohistochemistry: In paraffin embedded Kidney shows strong cytoplasmic staining of epithelial cells in distal convoluted tubules. Recommended concentration, 2-3ug/ml.
Western Blot: Preliminary experiments gave an approx 38kDa band in Human Lung Carcinoma A549 cell line and cervix epitheloid carcinoma cell line HeLa lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 192kDa according to NP_689969.2. The 38kDa band was successfully blocked by incubation with the immunizing peptide.
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 Immunohistochemistry (IHC) of anti-RICTOR antibody    (2.5ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-RICTOR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RICTOR. It may not necessarily be applicable to this product.
 NCBI GI #    59891448
 NCBI GeneID    253260
 NCBI Accession #    NP_689969.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_152756.4 [Other Products]
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 UniProt Secondary Accession #    Q68DT5; Q86UB7; Q8N3A0; Q8NCM6; B2RNX0; B7ZMF7 [Other Products]
 UniProt Related Accession #    Q6R327 [Other Products]
 Molecular Weight    195,011 Da
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 NCBI Official Full Name    rapamycin-insensitive companion of mTOR isoform 1
 NCBI Official Synonym Full Names    RPTOR independent companion of MTOR complex 2
 NCBI Official Symbol    RICTOR [Similar Products]
 NCBI Official Synonym Symbols   
PIA; AVO3; hAVO3
[Similar Products]
 NCBI Protein Information    rapamycin-insensitive companion of mTOR
 UniProt Protein Name    Rapamycin-insensitive companion of mTOR
 UniProt Synonym Protein Names   
AVO3 homolog; hAVO3
 Protein Family    Rapamycin-insensitive companion
 UniProt Gene Name    RICTOR [Similar Products]
 UniProt Synonym Gene Names    hAVO3 [Similar Products]
 UniProt Entry Name    RICTR_HUMAN
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 NCBI Summary for RICTOR    RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for RICTOR    RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae.

Protein type: Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: cytosol; TORC2 complex

Molecular Function: enzyme activator activity; protein binding; protein kinase binding; ribosome binding

Biological Process: actin cytoskeleton reorganization; embryonic development; establishment and/or maintenance of actin cytoskeleton polarity; establishment of cell polarity; peptidyl-serine phosphorylation; phosphoinositide-mediated signaling; positive regulation of actin filament polymerization; positive regulation of catalytic activity; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of TOR signaling pathway; regulation of actin cytoskeleton organization and biogenesis; regulation of gene expression; regulation of GTPase activity; regulation of inflammatory response; regulation of peptidyl-serine phosphorylation; regulation of phosphorylation; regulation of protein kinase B signaling cascade; T cell costimulation; TOR signaling pathway
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 Research Articles on RICTOR    1. the expressions of Beclin1, Raptor, and Rictor are related to the development and progression of colorectal carcinoma and multidrug resistance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RICTOR antibodyPathways associated with anti-RICTOR antibody
 Reference Product  PubMed Publications
 MTOR antibody  >474 publications with RICTOR and MTOR
 RPTOR antibody  >101 publications with RICTOR and RPTOR
 MLST8 antibody  >33 publications with RICTOR and MLST8
 AKT1 antibody  >29 publications with RICTOR and AKT1
 EIF4EBP1 antibody  >18 publications with RICTOR and EIF4EBP1
 MAPKAP1 antibody  >17 publications with RICTOR and MAPKAP1
 SGK1 antibody  >15 publications with RICTOR and SGK1
 AKT1S1 antibody  >6 publications with RICTOR and AKT1S1
 RPS6KB1 antibody  >3 publications with RICTOR and RPS6KB1
 PRR5L antibody  >1 publications with RICTOR and PRR5L
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Constitutive Signaling By AKT1 E17K In Cancer Pathway antibodies  Constitutive Signaling By AKT1 E17K In Cancer Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
Diseases associated with anti-RICTOR antibodyOrgans/Tissues associated with anti-RICTOR antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >35 publications with RICTOR and Insulin Resistance
 Disease Models, Animal Antibodies  >30 publications with RICTOR and Disease Models, Animal
 Kidney Diseases Antibodies  >21 publications with RICTOR and Kidney Diseases
 Adenocarcinoma Antibodies  >20 publications with RICTOR and Adenocarcinoma
 Breast Neoplasms Antibodies  >20 publications with RICTOR and Breast Neoplasms
 Neoplasm Invasiveness Antibodies  >18 publications with RICTOR and Neoplasm Invasiveness
 Inflammation Antibodies  >16 publications with RICTOR and Inflammation
 Cell Transformation, Neoplastic Antibodies  >15 publications with RICTOR and Cell Transformation, Neoplastic
 Hypertrophy Antibodies  >14 publications with RICTOR and Hypertrophy
 Neoplasms, Experimental Antibodies  >14 publications with RICTOR and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >74 publications with RICTOR and Blood
 Muscle Antibodies  >58 publications with RICTOR and Muscle
 Vascular Antibodies  >37 publications with RICTOR and Vascular
 Brain Antibodies  >34 publications with RICTOR and Brain
 Liver Antibodies  >31 publications with RICTOR and Liver
 Kidney Antibodies  >31 publications with RICTOR and Kidney
 Lung Antibodies  >29 publications with RICTOR and Lung
 Bone Antibodies  >23 publications with RICTOR and Bone
 Prostate Antibodies  >22 publications with RICTOR and Prostate
 Adipose Tissue Antibodies  >19 publications with RICTOR and Adipose Tissue
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