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anti-RICTOR antibody :: Rabbit anti-Human, mouse RICTOR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9213882
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RICTOR, Polyclonal Antibody

★Popular Item★
 Also Known As   

Purified Rabbit Polyclonal Antibody (Pab)

 Product Synonym Names    Rapamycin-insensitive companion of mTOR; AVO3 homolog; hAVO3; RICTOR {ECO:0000312|EMBL:EAW559801}
 Product Gene Name   

anti-RICTOR antibody

[Similar Products]
 Antibody/Peptide Pairs    RICTOR peptide (MBS9226728) is used for blocking the activity of RICTOR antibody (MBS9213882)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    805-835
 OMIM    609022
 3D Structure    ModBase 3D Structure for Q6R327
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Specificity    This RICTOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-835 amino acids from the Central region of human RICTOR.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
 Concentration    Vial Concentration: 2 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-RICTOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RICTOR antibody

   Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
 Product Categories/Family for anti-RICTOR antibody    Cell Biology; Signal Transduction
 Applications Tested/Suitable for anti-RICTOR antibody   

Western Blot (WB)

 Application Notes for anti-RICTOR antibody    WB~~1:1000
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 Western Blot (WB) of anti-RICTOR antibody    RICTOR Antibody (Center) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the RICTOR antibody detected the RICTOR protein (arrow).
anti-RICTOR antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for RICTOR. It may not necessarily be applicable to this product.
 NCBI GI #    59891448
 NCBI GeneID    253260
 NCBI Accession #    NP_689969.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_152756.4 [Other Products]
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 UniProt Primary Accession #    Q6R327 [Other Products]
 UniProt Secondary Accession #    Q68DT5; Q86UB7; Q8N3A0; Q8NCM6; B2RNX0; B7ZMF7 [Other Products]
 UniProt Related Accession #    Q6R327 [Other Products]
 Molecular Weight    192218
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 NCBI Official Full Name    rapamycin-insensitive companion of mTOR isoform 1
 NCBI Official Synonym Full Names    RPTOR independent companion of MTOR, complex 2
 NCBI Official Symbol    RICTOR [Similar Products]
 NCBI Official Synonym Symbols   
PIA; AVO3; hAVO3
[Similar Products]
 NCBI Protein Information    rapamycin-insensitive companion of mTOR
 UniProt Protein Name    Rapamycin-insensitive companion of mTOR
 UniProt Synonym Protein Names   
AVO3 homolog; hAVO3
 Protein Family    Rapamycin-insensitive companion
 UniProt Gene Name    RICTOR [Similar Products]
 UniProt Synonym Gene Names    hAVO3 [Similar Products]
 UniProt Entry Name    RICTR_HUMAN
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 NCBI Summary for RICTOR    RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for RICTOR    RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae.

Protein type: Cell cycle regulation; Adaptor/scaffold; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: TORC2 complex; cytosol

Molecular Function: protein binding; ribosome binding; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; TOR signaling pathway; nerve growth factor receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-serine phosphorylation; embryonic development; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; T cell costimulation; innate immune response; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; positive regulation of TOR signaling pathway
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Product References and Citations for anti-RICTOR antibody

   Pearce,L.R., Biochem. J. 405 (3), 513-522 (2007)
Yang,Q., Genes Dev. 20 (20), 2820-2832 (2006)
Jacinto,E., Cell 127 (1), 125-137 (2006)
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 Research Articles on RICTOR    1. these data provide evidence that rictor is a multifunctional signaling regulator that can regulate FcepsilonRI-mediated degranulation independently of mTORC2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RICTOR antibodyPathways associated with anti-RICTOR antibody
 Reference Product  PubMed Publications
 MTOR antibody  >387 publications with RICTOR and MTOR
 RPTOR antibody  >82 publications with RICTOR and RPTOR
 MLST8 antibody  >32 publications with RICTOR and MLST8
 AKT1 antibody  >22 publications with RICTOR and AKT1
 EIF4EBP1 antibody  >16 publications with RICTOR and EIF4EBP1
 MAPKAP1 antibody  >16 publications with RICTOR and MAPKAP1
 SGK1 antibody  >15 publications with RICTOR and SGK1
 AKT1S1 antibody  >6 publications with RICTOR and AKT1S1
 RPS6KB1 antibody  >3 publications with RICTOR and RPS6KB1
 PRR5L antibody  >1 publications with RICTOR and PRR5L
 Products by Pathway  Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
Diseases associated with anti-RICTOR antibodyOrgans/Tissues associated with anti-RICTOR antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >30 publications with RICTOR and Insulin Resistance
 Disease Models, Animal Antibodies  >24 publications with RICTOR and Disease Models, Animal
 Kidney Diseases Antibodies  >19 publications with RICTOR and Kidney Diseases
 Breast Neoplasms Antibodies  >17 publications with RICTOR and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >14 publications with RICTOR and Neoplasms, Experimental
 Inflammation Antibodies  >14 publications with RICTOR and Inflammation
 Adenocarcinoma Antibodies  >13 publications with RICTOR and Adenocarcinoma
 Neoplasm Invasiveness Antibodies  >13 publications with RICTOR and Neoplasm Invasiveness
 Hypertrophy Antibodies  >12 publications with RICTOR and Hypertrophy
 Necrosis Antibodies  >11 publications with RICTOR and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >61 publications with RICTOR and Blood
 Muscle Antibodies  >48 publications with RICTOR and Muscle
 Vascular Antibodies  >29 publications with RICTOR and Vascular
 Brain Antibodies  >29 publications with RICTOR and Brain
 Kidney Antibodies  >28 publications with RICTOR and Kidney
 Liver Antibodies  >24 publications with RICTOR and Liver
 Prostate Antibodies  >21 publications with RICTOR and Prostate
 Bone Antibodies  >21 publications with RICTOR and Bone
 Lung Antibodies  >18 publications with RICTOR and Lung
 Adipose Tissue Antibodies  >16 publications with RICTOR and Adipose Tissue
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