NP_060621.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
271,689 Da
NCBI Official Full Name
telomere-associated protein RIF1 isoform 1
NCBI Official Synonym Full Names
replication timing regulatory factor 1
NCBI Protein Information
telomere-associated protein RIF1
UniProt Protein Name
Telomere-associated protein RIF1
UniProt Synonym Protein Names
Rap1-interacting factor 1 homolog
UniProt Entry Name
RIF1_HUMAN
NCBI Summary for RIF1
This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
UniProt Comments for RIF1
RIF1: Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S- phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 2q23.3
Cellular Component: condensed chromosome; nucleoplasm; nucleus; plasma membrane; spindle midzone
Biological Process: double-strand break repair via nonhomologous end joining; telomere maintenance in response to DNA damage
Research Articles on RIF1
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Products associated with anti-RIF1 antibody
Pathways associated with anti-RIF1 antibody
Diseases associated with anti-RIF1 antibody
Organs/Tissues associated with anti-RIF1 antibody
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