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anti-RARRES3 antibody :: Goat RIG1/RARRES3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421596 anti-RARRES3 antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RIG1/RARRES3, Polyclonal Antibody

 Also Known As   

Goat anti-RIG1/RARRES3 (aa 124 to 136) Antibody

 Product Synonym Names    Goat Anti-RIG1 / RARRES3 (aa 119 to 134) Antibody; RARRES3; retinoic acid receptor responder (tazarotene induced) 3; HRASLS4; MGC8906; RIG1; TIG3; RARRES3 antibody; retinoic acid receptor responder (tazarotene induced) 3 antibody; HRASLS4 antibody; MGC8906 antibody; RIG1 antibody; TIG3 antibody; RIG1 / RARRES3 (aa 124 to 136)
 Product Gene Name   

anti-RARRES3 antibody

[Similar Products]
 Product Synonym Gene Name    RIG1 [Similar Products]
 Antibody/Peptide Pairs    RIG1 / RARRES3 peptide (MBS426283) is used for blocking the activity of RIG1/RARRES3 antibody (MBS421596)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KSRCKQVEKA KVE
 OMIM    605092
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence KSRCKQVEKAKVE, from the internal region of the protein sequence according to NP_004576.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-RARRES3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RARRES3 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-RARRES3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Preliminary experiments gave bands at approx 22kDa and 55kDa in Human Thymus lysates after 1ug/ml antibody staining. The 55kDa band was observed in all tissues tested. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 18.8kDa according to NP_004576.2. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
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NCBI/Uniprot data below describe general gene information for RARRES3. It may not necessarily be applicable to this product.
 NCBI GI #    149588791
 NCBI GeneID    5920
 NCBI Accession #    NP_004576.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004585.4 [Other Products]
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 UniProt Secondary Accession #    O95200; B2R599; B4DDW2; E7ENZ7 [Other Products]
 UniProt Related Accession #    Q9UL19 [Other Products]
 Molecular Weight    17,436 Da
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 NCBI Official Full Name    retinoic acid receptor responder protein 3
 NCBI Official Synonym Full Names    retinoic acid receptor responder 3
 NCBI Official Symbol    RARRES3 [Similar Products]
 NCBI Official Synonym Symbols   
RIG1; TIG3; HRSL4; HRASLS4; PLA1/2-3
[Similar Products]
 NCBI Protein Information    retinoic acid receptor responder protein 3
 UniProt Protein Name    Retinoic acid receptor responder protein 3
 UniProt Synonym Protein Names   
HRAS-like suppressor 4; HRSL4; RAR-responsive protein TIG3; Retinoid-inducible gene 1 protein; Tazarotene-induced gene 3 protein
 Protein Family    Retinoic acid receptor responder protein
 UniProt Gene Name    RARRES3 [Similar Products]
 UniProt Synonym Gene Names    RIG1; TIG3; HRSL4 [Similar Products]
 UniProt Entry Name    HRSL4_HUMAN
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 NCBI Summary for RARRES3    Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RARRES3    RARRES3: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable. Belongs to the H-rev107 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.-; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: integral to membrane

Molecular Function: phospholipase A2 activity; protein binding

Biological Process: lipid catabolic process; negative regulation of cell proliferation; phospholipid metabolic process
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 Research Articles on RARRES3    1. These observations highlight the importance of RIG-I signaling in anti-HIV innate immunity in macrophages, which may be beneficial for the treatment of HIV and aid in the understanding of the neuropathogenesis of HAND.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-RARRES3 antibodyOrgans/Tissues associated with anti-RARRES3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with RARRES3 and Inflammation
 Breast Neoplasms Antibodies  >6 publications with RARRES3 and Breast Neoplasms
 Adenocarcinoma Antibodies  >6 publications with RARRES3 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >5 publications with RARRES3 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >5 publications with RARRES3 and Lung Diseases
 Necrosis Antibodies  >5 publications with RARRES3 and Necrosis
 Lung Neoplasms Antibodies  >4 publications with RARRES3 and Lung Neoplasms
 Kidney Diseases Antibodies  >4 publications with RARRES3 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with RARRES3 and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >3 publications with RARRES3 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >10 publications with RARRES3 and Skin
 Lung Antibodies  >10 publications with RARRES3 and Lung
 Blood Antibodies  >9 publications with RARRES3 and Blood
 Kidney Antibodies  >6 publications with RARRES3 and Kidney
 Vascular Antibodies  >5 publications with RARRES3 and Vascular
 Brain Antibodies  >4 publications with RARRES3 and Brain
 Liver Antibodies  >3 publications with RARRES3 and Liver
 Stomach Antibodies  >3 publications with RARRES3 and Stomach
 Mouth Antibodies  >3 publications with RARRES3 and Mouth
 Prostate Antibodies  >2 publications with RARRES3 and Prostate
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