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anti-RIPK1 antibody :: Rabbit RIPK1 / RIP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS244907
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RIPK1 / RIP, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human RIPK1 / RIP

 Product Synonym Names    Anti-RIPK1 / RIP Antibody (N-Terminus) IHC-plus; RIPK1; Cell death protein RIP; Receptor interacting protein; RIP1; RIP; RIP-1; Protein kinase rip; Receptor-interacting protein 1; Rinp; Human RIPK1; RIP
 Product Gene Name   

anti-RIPK1 antibody

[Similar Products]
 Product Synonym Gene Name    RIP [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603453
 3D Structure    ModBase 3D Structure for Q13546
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Human RIPK1
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    A 15 amino acid peptide from near the amino terminus of human RIPK1.
 Immunogen Type    Synthetic peptide
 Immunogen    RIPK1 / RIP antibody was raised against a 15 amino acid peptide from near the amino terminus of human RIPK1.
 Antigen Modification    N-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-RIPK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-RIPK1 antibody

   RIP1 belongs to the RIP subfamily of kinases. The RIP protein contains an N-terminal protein kinase domain, a C-terminal death domain, and a unique internal region. RIP interacts with the death receptors Fas and tumor necrosis receptor 1 (TNFR1) to stimulate apoptosis, SAPK/JNK, and NF-kappaB activation.
 Product Categories/Family for anti-RIPK1 antibody    Family: Protein Kinase
Subfamily: RIP
 Applications Tested/Suitable for anti-RIPK1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-RIPK1 antibody    ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: RIPK1 antibody can be used for detection of RIPK1 by Western blot at 1-2 ug/ml.
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 Immunohistochemistry (IHC) of anti-RIPK1 antibody    Anti-RIPK1 /RIP antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-RIPK1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-RIPK1 antibody    Immunofluorescence of RIPK1 in Mouse Kidney cells with RIPK1 antibody at 20 ug/ml.
anti-RIPK1 antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-RIPK1 antibody    Western blot of RIPK1 in rat kidney tissue lysate with RIPK1 antibody at 1 ug/ml.
anti-RIPK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for RIPK1. It may not necessarily be applicable to this product.
 NCBI GI #    57242761
 NCBI GeneID    8737
 NCBI Accession #    NP_003795.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003804.3 [Other Products]
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 UniProt Primary Accession #    Q13546 [Other Products]
 UniProt Secondary Accession #    Q13180; Q59H33; A0AV89; B2RAG1; B4E3F9 [Other Products]
 UniProt Related Accession #    Q13546 [Other Products]
 Molecular Weight    70,733 Da
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 NCBI Official Full Name    receptor-interacting serine/threonine-protein kinase 1
 NCBI Official Synonym Full Names    receptor (TNFRSF)-interacting serine-threonine kinase 1
 NCBI Official Symbol    RIPK1 [Similar Products]
 NCBI Official Synonym Symbols   
RIP; RIP1
[Similar Products]
 NCBI Protein Information    receptor-interacting serine/threonine-protein kinase 1; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-protein kinase RIP
 UniProt Protein Name    Receptor-interacting serine/threonine-protein kinase 1
 UniProt Synonym Protein Names   
Cell death protein RIP; Receptor-interacting protein 1; RIP-1; Serine/threonine-protein kinase RIP
 Protein Family    Receptor-interacting serine/threonine-protein kinase
 UniProt Gene Name    RIPK1 [Similar Products]
 UniProt Synonym Gene Names    RIP; RIP1; RIP-1 [Similar Products]
 UniProt Entry Name    RIPK1_HUMAN
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 UniProt Comments for RIPK1    RIPK1: Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex. Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Inhibited by necrostatin-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, TKL; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; RIPK family

Chromosomal Location of Human Ortholog: 6p25.2

Cellular Component: mitochondrion; cytoplasm; cytosol; receptor complex; lipid raft

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; death receptor binding; protein complex binding; ATP binding; protein kinase activity

Biological Process: apoptosis; positive regulation of apoptosis; protein heterooligomerization; protein amino acid autophosphorylation; positive regulation of JNK cascade; toll-like receptor 3 signaling pathway; activation of JNK activity; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; tumor necrosis factor-mediated signaling pathway; positive regulation of interferon type I production; positive regulation of macrophage differentiation; toll-like receptor 4 signaling pathway; protein homooligomerization; caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of tumor necrosis factor production; positive regulation of programmed cell death; cellular protein catabolic process; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation
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 Research Articles on RIPK1    1. beta-lapachone induces programmed necrosis through the NQO1-dependent ROS-mediated RIP1-PARP1-AIF pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RIPK1 antibodyPathways associated with anti-RIPK1 antibody
 Reference Product  PubMed Publications
 CASP8 antibody  >117 publications with RIPK1 and CASP8
 FADD antibody  >100 publications with RIPK1 and FADD
 RIPK3 antibody  >83 publications with RIPK1 and RIPK3
 TRAF2 antibody  >46 publications with RIPK1 and TRAF2
 TNFRSF1A antibody  >11 publications with RIPK1 and TNFRSF1A
 CRADD antibody  >6 publications with RIPK1 and CRADD
 IKBKG antibody  >5 publications with RIPK1 and IKBKG
 BIRC2 antibody  >4 publications with RIPK1 and BIRC2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-8 Activation By Cleavage Pathway antibodies  Caspase-8 Activation By Cleavage Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
Diseases associated with anti-RIPK1 antibodyOrgans/Tissues associated with anti-RIPK1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >257 publications with RIPK1 and Necrosis
 Inflammation Antibodies  >69 publications with RIPK1 and Inflammation
 Immune System Diseases Antibodies  >22 publications with RIPK1 and Immune System Diseases
 Cardiovascular Diseases Antibodies  >14 publications with RIPK1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >12 publications with RIPK1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >11 publications with RIPK1 and Nervous System Diseases
 Liver Diseases Antibodies  >7 publications with RIPK1 and Liver Diseases
 Kidney Diseases Antibodies  >5 publications with RIPK1 and Kidney Diseases
 Cerebral Infarction Antibodies  >5 publications with RIPK1 and Cerebral Infarction
 Heart Diseases Antibodies  >4 publications with RIPK1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >15 publications with RIPK1 and Lung
 Brain Antibodies  >15 publications with RIPK1 and Brain
 Kidney Antibodies  >14 publications with RIPK1 and Kidney
 Liver Antibodies  >13 publications with RIPK1 and Liver
 Bone Antibodies  >11 publications with RIPK1 and Bone
 Bone Marrow Antibodies  >10 publications with RIPK1 and Bone Marrow
 Embryonic Tissue Antibodies  >9 publications with RIPK1 and Embryonic Tissue
 Intestine Antibodies  >7 publications with RIPK1 and Intestine
 Pancreas Antibodies  >7 publications with RIPK1 and Pancreas
 Skin Antibodies  >6 publications with RIPK1 and Skin
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