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anti-RIPK1 / RIP antibody :: Rabbit anti-Human RIPK1 / RIP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS249624
Unit / Price
0.2 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RIPK1 / RIP, Polyclonal Antibody

 Also Known As   

Anti-RIPK1 / RIP Antibody (aa151-180) IHC-plus

 Product Synonym Names    Rabbit Polyclonal to Human RIPK1 / RIP; Human RIPK1 / RIP; Cell death protein RIP; Receptor interacting protein; RIP1; RIP-1; Protein kinase rip; Receptor-interacting protein 1; Rinp
 Product Gene Name   

anti-RIPK1 / RIP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603453
 3D Structure    ModBase 3D Structure for Q13546
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human RIP
 Purity/Purification    Immunoaffinity purified
 Form/Format    PBS, 0.09% sodium azide
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 Immunogen    RIPK1 / RIP antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human RIPK1.
 Immunogen Description    KLH-conjugated synthetic peptide from N-terminal region of human RIPK1.
 Immunogen Type    Synthetic peptide
 Antigen Modification    aa151-180
 Target Species    Human
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
 Other Notes    Small volumes of anti-RIPK1 / RIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RIPK1 / RIP antibody

   RIPK1 Antibody, Cell death protein RIP Antibody, Receptor interacting protein Antibody, RIP1 Antibody, RIP Antibody, RIP-1 Antibody, Protein kinase rip Antibody, Receptor-interacting protein 1 Antibody, Rinp Antibody Description: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade.
 Applications Tested/Suitable for anti-RIPK1 / RIP antibody   

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

 Application Notes for anti-RIPK1 / RIP antibody    IHC-P (1:100)
WB (1:1000)
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 Immunohistochemistry - Paraffin (IHC) of anti-RIPK1 / RIP antibody    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-RIPK1 / RIP antibody Immunohistochemistry - Paraffin (IHC) (IHC) image
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 Immunohistochemistry - Paraffin (IHC) of anti-RIPK1 / RIP antibody    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-RIPK1 / RIP antibody Immunohistochemistry - Paraffin (IHC) (IHC) image
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 Western Blot (WB) of anti-RIPK1 / RIP antibody    RIPK1 Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The RIPK1 antibody detected the RIPK1 protein (arrow).
anti-RIPK1 / RIP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for RIPK1 / RIP. It may not necessarily be applicable to this product.
 NCBI GI #    57242761
 NCBI GeneID    8737
 NCBI Accession #    NP_003795.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003804.4 [Other Products]
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 UniProt Primary Accession #    Q13546 [Other Products]
 UniProt Secondary Accession #    Q13180; Q59H33; A0AV89; B2RAG1; B4E3F9 [Other Products]
 UniProt Related Accession #    Q13546 [Other Products]
 Molecular Weight    70,733 Da
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 NCBI Official Full Name    receptor-interacting serine/threonine-protein kinase 1 isoform 1
 NCBI Official Synonym Full Names    receptor interacting serine/threonine kinase 1
 NCBI Official Symbol    RIPK1 [Similar Products]
 NCBI Official Synonym Symbols   
RIP; RIP1; RIP-1
[Similar Products]
 NCBI Protein Information    receptor-interacting serine/threonine-protein kinase 1
 UniProt Protein Name    Receptor-interacting serine/threonine-protein kinase 1
 UniProt Synonym Protein Names   
Cell death protein RIP; Receptor-interacting protein 1; RIP-1; Serine/threonine-protein kinase RIP
 UniProt Gene Name    RIPK1 [Similar Products]
 UniProt Synonym Gene Names    RIP; RIP1; RIP-1 [Similar Products]
 UniProt Entry Name    RIPK1_HUMAN
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 UniProt Comments for RIPK1 / RIP    RIPK1: Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex. Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Inhibited by necrostatin-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, TKL; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; RIPK family

Chromosomal Location of Human Ortholog: 6p25.2

Cellular Component: cytoplasm; cytosol; lipid raft; mitochondrion; receptor complex

Molecular Function: ATP binding; death receptor binding; identical protein binding; protein binding; protein complex binding; protein kinase activity; protein serine/threonine kinase activity; ubiquitin protein ligase binding

Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; apoptosis; caspase activation; cell surface receptor linked signal transduction; cellular protein catabolic process; I-kappaB kinase/NF-kappaB cascade; innate immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of caspase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of macrophage differentiation; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; programmed cell death; protein amino acid autophosphorylation; protein heterooligomerization; protein homooligomerization; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway
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 Research Articles on RIPK1 / RIP    1. These data demonstrate that RIP1 is essential for the regulation of death receptor mediated autophagy and apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RIPK1 / RIP antibodyPathways associated with anti-RIPK1 / RIP antibody
 Reference Product  PubMed Publications
 CASP8 antibody  >143 publications with RIPK1 / RIP and CASP8
 RIPK3 antibody  >135 publications with RIPK1 / RIP and RIPK3
 FADD antibody  >112 publications with RIPK1 / RIP and FADD
 TRADD antibody  >61 publications with RIPK1 / RIP and TRADD
 TRAF2 antibody  >48 publications with RIPK1 / RIP and TRAF2
 TRAF1 antibody  >34 publications with RIPK1 / RIP and TRAF1
 TNFRSF1A antibody  >15 publications with RIPK1 / RIP and TNFRSF1A
 IKBKG antibody  >5 publications with RIPK1 / RIP and IKBKG
 BIRC2 antibody  >4 publications with RIPK1 / RIP and BIRC2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 CASP8 Activity Is Inhibited Pathway antibodies  CASP8 Activity Is Inhibited Pathway Diagram
 Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies  Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
Diseases associated with anti-RIPK1 / RIP antibodyOrgans/Tissues associated with anti-RIPK1 / RIP antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >311 publications with RIPK1 / RIP and Necrosis
 Inflammation Antibodies  >95 publications with RIPK1 / RIP and Inflammation
 Disease Models, Animal Antibodies  >20 publications with RIPK1 / RIP and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >17 publications with RIPK1 / RIP and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >13 publications with RIPK1 / RIP and Nervous System Diseases
 Liver Diseases Antibodies  >10 publications with RIPK1 / RIP and Liver Diseases
 Lung Neoplasms Antibodies  >7 publications with RIPK1 / RIP and Lung Neoplasms
 Lung Diseases Antibodies  >7 publications with RIPK1 / RIP and Lung Diseases
 Kidney Diseases Antibodies  >6 publications with RIPK1 / RIP and Kidney Diseases
 Acute Kidney Injury Antibodies  >6 publications with RIPK1 / RIP and Acute Kidney Injury
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with RIPK1 / RIP and Brain
 Liver Antibodies  >18 publications with RIPK1 / RIP and Liver
 Kidney Antibodies  >17 publications with RIPK1 / RIP and Kidney
 Lung Antibodies  >15 publications with RIPK1 / RIP and Lung
 Bone Antibodies  >12 publications with RIPK1 / RIP and Bone
 Bone Marrow Antibodies  >11 publications with RIPK1 / RIP and Bone Marrow
 Embryonic Tissue Antibodies  >11 publications with RIPK1 / RIP and Embryonic Tissue
 Skin Antibodies  >8 publications with RIPK1 / RIP and Skin
 Intestine Antibodies  >8 publications with RIPK1 / RIP and Intestine
 Muscle Antibodies  >7 publications with RIPK1 / RIP and Muscle
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