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anti-RIPK1 antibody :: Rabbit anti-Human RIPK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6005404 anti-RIPK1 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RIPK1, Polyclonal Antibody

 Also Known As   

RIPK1, NT (RIPK1, RIP, RIP1, Receptor-interacting serine/threonine-protein kinase 1, Cell death protein RIP, Receptor-interacting protein 1, Serine/threonine-protein kinase RIP)

 Product Synonym Names    Anti -RIPK1, NT (RIPK1, RIP, RIP1, Receptor-interacting serine/threonine-protein kinase 1, Cell death protein RIP, Receptor-interacting protein 1, Serine/threonine-protein kinase RIP)
 Product Gene Name   

anti-RIPK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (3064201..3115421). Location: 6p25.2
 OMIM    603453
 3D Structure    ModBase 3D Structure for Q13546
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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 Immunogen    RIPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the N-terminal region of human RIPK1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-RIPK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RIPK1 antibody

   Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
 Product Categories/Family for anti-RIPK1 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-RIPK1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-RIPK1 antibody    Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50
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NCBI/Uniprot data below describe general gene information for RIPK1. It may not necessarily be applicable to this product.
 NCBI GI #    57242761
 NCBI GeneID    8737
 NCBI Accession #    NP_003795.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003804.3 [Other Products]
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 UniProt Primary Accession #    Q13546 [Other Products]
 UniProt Secondary Accession #    Q13180; Q59H33; A0AV89; B2RAG1; B4E3F9 [Other Products]
 UniProt Related Accession #    Q13546 [Other Products]
 Molecular Weight    75,931 Da [Similar Products]
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 NCBI Official Full Name    receptor-interacting serine/threonine-protein kinase 1
 NCBI Official Synonym Full Names    receptor (TNFRSF)-interacting serine-threonine kinase 1
 NCBI Official Symbol    RIPK1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    receptor-interacting serine/threonine-protein kinase 1; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-protein kinase RIP
 UniProt Protein Name    Receptor-interacting serine/threonine-protein kinase 1
 UniProt Synonym Protein Names   
Cell death protein RIP; Receptor-interacting protein 1; RIP-1; Serine/threonine-protein kinase RIP
 Protein Family    Receptor-interacting serine/threonine-protein kinase
 UniProt Gene Name    RIPK1 [Similar Products]
 UniProt Synonym Gene Names    RIP; RIP1; RIP-1 [Similar Products]
 UniProt Entry Name    RIPK1_HUMAN
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 UniProt Comments for RIPK1    RIPK1: Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex. Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Inhibited by necrostatin-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; TKL group; RIPK family

Chromosomal Location of Human Ortholog: 6p25.2

Cellular Component: mitochondrion; cytoplasm; cytosol; receptor complex; lipid raft

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; death receptor binding; protein complex binding; ATP binding; protein kinase activity

Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein heterooligomerization; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; MyD88-independent toll-like receptor signaling pathway; positive regulation of JNK cascade; toll-like receptor 3 signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of tumor necrosis factor production; activation of JNK activity; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; positive regulation of programmed cell death; tumor necrosis factor-mediated signaling pathway; cellular protein catabolic process; positive regulation of interferon type I production; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; positive regulation of macrophage differentiation; toll-like receptor 4 signaling pathway; protein homooligomerization
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 Research Articles on RIPK1    1. Results demonstrate that in the absence of caspase 6 activity, intrinsic triggers of apoptosis induce the receptor-interacting-kinase-1-dependent production of pro-inflammatory cytokines.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RIPK1 antibodyPathways associated with anti-RIPK1 antibody
 Reference Product  PubMed Publications
 CASP8 antibody  >91 publications with RIPK1 and CASP8
 FADD antibody  >87 publications with RIPK1 and FADD
 TRAF2 antibody  >44 publications with RIPK1 and TRAF2
 RIPK3 antibody  >39 publications with RIPK1 and RIPK3
 CRADD antibody  >6 publications with RIPK1 and CRADD
 IKBKG antibody  >5 publications with RIPK1 and IKBKG
 TNFRSF1A antibody  >5 publications with RIPK1 and TNFRSF1A
 BIRC2 antibody  >3 publications with RIPK1 and BIRC2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-8 Activation Pathway antibodies  Caspase-8 Activation Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
Diseases associated with anti-RIPK1 antibodyOrgans/Tissues associated with anti-RIPK1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >202 publications with RIPK1 and Necrosis
 Neoplasms Antibodies  >40 publications with RIPK1 and Neoplasms
 Inflammation Antibodies  >39 publications with RIPK1 and Inflammation
 Disease Models, Animal Antibodies  >9 publications with RIPK1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >6 publications with RIPK1 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >3 publications with RIPK1 and Neoplasm Metastasis
 Atherosclerosis Antibodies  >3 publications with RIPK1 and Atherosclerosis
 Liver Diseases Antibodies  >3 publications with RIPK1 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with RIPK1 and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >2 publications with RIPK1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >13 publications with RIPK1 and Lung
 Brain Antibodies  >12 publications with RIPK1 and Brain
 Kidney Antibodies  >11 publications with RIPK1 and Kidney
 Embryonic Tissue Antibodies  >7 publications with RIPK1 and Embryonic Tissue
 Liver Antibodies  >6 publications with RIPK1 and Liver
 Pancreas Antibodies  >6 publications with RIPK1 and Pancreas
 Skin Antibodies  >4 publications with RIPK1 and Skin
 Muscle Antibodies  >4 publications with RIPK1 and Muscle
 Bone Antibodies  >4 publications with RIPK1 and Bone
 Vascular Antibodies  >4 publications with RIPK1 and Vascular
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