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anti-RNASEH2A antibody :: Rabbit RNAse H2A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151275
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RNAse H2A (RNASEH2A), Polyclonal Antibody

 Also Known As   

RNAse H2A Antibody

 Product Synonym Names    RNAse H2A; AGS4; JUNB; RNHL; RNHIA; RNASEHI; Ribonuclease H2 subunit A; Aicardi-Goutieres syndrome 4 protein; RNase H2 subunit A; ribonuclease H2, subunit A
 Product Gene Name   

anti-RNASEH2A antibody

[Similar Products]
 Antibody/Peptide Pairs    RNAse H2A peptide (MBS152561) is used for blocking the activity of RNAse H2A antibody (MBS151275)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 610333
 3D Structure    ModBase 3D Structure for O75792
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    RNAse H2A Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    RNAse H2A antibody was raised against a 17 amino acid synthetic peptide near the center of human RNAse H2A.
 Buffer    RNAse H2A Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    RNAse H2A antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-RNASEH2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RNASEH2A antibody

   RNAse H2A Antibody: Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
 Applications Tested/Suitable for anti-RNASEH2A antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-RNASEH2A antibody    RNAse H2A antibody can be used for detection of RNAse H2A by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 2 mug/mL. For immunofluorescence start at 4 mug/mL.
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 Western Blot (WB) of anti-RNASEH2A antibody    Western blot analysis of RNAse H2A in HeLa cell lysate with RNAse H2A antibody at 1 μg/mL.
anti-RNASEH2A antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-RNASEH2A antibody    Immunocytochemistry of RNAse H2A in HeLa cells with RNAse H2A antibody at 2 μg/mL.
anti-RNASEH2A antibody Immunocytochemistry (ICC) (ICC) image
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 Immunofluorescence (IF) of anti-RNASEH2A antibody    Immunofluorescence of Rnse H2A in Hela cells with Rnse H2A antibody at 4.75 μg/mL.
anti-RNASEH2A antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for RNASEH2A. It may not necessarily be applicable to this product.
 NCBI GI #    20981704
 NCBI GeneID    10535
 NCBI Accession #    O75792.2 [Other Products]
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 UniProt Primary Accession #    O75792 [Other Products]
 UniProt Secondary Accession #    Q96F11; B2RCY1 [Other Products]
 UniProt Related Accession #    O75792 [Other Products]
 Molecular Weight    33,395 Da
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 NCBI Official Full Name    Ribonuclease H2 subunit A
 NCBI Official Synonym Full Names    ribonuclease H2, subunit A
 NCBI Official Symbol    RNASEH2A [Similar Products]
 NCBI Official Synonym Symbols   
AGS4; JUNB; RNHL; RNHIA; RNASEHI
[Similar Products]
 NCBI Protein Information    ribonuclease H2 subunit A; RNase H(35); RNase H2 subunit A; RNase HI large subunit; ribonuclease HI subunit A; ribonuclease HI large subunit; ribonuclease H2, large subunit; ribonuclease HI, large subunit; aicardi-Goutieres syndrome 4 protein
 UniProt Protein Name    Ribonuclease H2 subunit A
 UniProt Synonym Protein Names   
Aicardi-Goutieres syndrome 4 protein; AGS4; RNase H(35); Ribonuclease HI large subunit; RNase HI large subunit; Ribonuclease HI subunit A
 Protein Family    Ribonuclease
 UniProt Gene Name    RNASEH2A [Similar Products]
 UniProt Synonym Gene Names    RNASEHI; RNHIA; RNase H2 subunit A; AGS4; RNase HI large subunit [Similar Products]
 UniProt Entry Name    RNH2A_HUMAN
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 NCBI Summary for RNASEH2A    The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
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 UniProt Comments for RNASEH2A    RNASEH2A: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2A are the cause of Aicardi-Goutieres syndrome type 4 (AGS4). A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Belongs to the RNase HII family. Eukaryotic subfamily.

Protein type: Ribonuclease; EC 3.1.26.4; DNA replication

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nucleus

Molecular Function: RNA binding; metal ion binding; ribonuclease H activity; ribonuclease activity

Biological Process: mismatch repair; RNA catabolic process; DNA replication

Disease: Aicardi-goutieres Syndrome 4
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 Research Articles on RNASEH2A    1. study identified two synonymous variants in RNASEH2A that result in loss of RNase H2 enzyme function and the consequent Aicardi-Goutieres syndrome phenotype
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RNASEH2A antibodyPathways associated with anti-RNASEH2A antibody
 Reference Product  PubMed Publications
 RNASEH2C antibody  >6 publications with RNASEH2A and RNASEH2C
 RNASEH2B antibody  >5 publications with RNASEH2A and RNASEH2B
 PCNA antibody  >1 publications with RNASEH2A and PCNA
 Products by Pathway  Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
Diseases associated with anti-RNASEH2A antibodyOrgans/Tissues associated with anti-RNASEH2A antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2 publications with RNASEH2A and Necrosis
 Aicardi-Goutieres Syndrome 4 Antibodies  >2 publications with RNASEH2A and Aicardi-Goutieres Syndrome 4
 Neoplasm Metastasis Antibodies  >1 publications with RNASEH2A and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >1 publications with RNASEH2A and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with RNASEH2A and Cell Transformation, Neoplastic
 Inflammation Antibodies  >1 publications with RNASEH2A and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with RNASEH2A and Blood
 Brain Antibodies  >2 publications with RNASEH2A and Brain
 Liver Antibodies  >1 publications with RNASEH2A and Liver
 Muscle Antibodies  >1 publications with RNASEH2A and Muscle
 Prostate Antibodies  >1 publications with RNASEH2A and Prostate
 Skin Antibodies  >1 publications with RNASEH2A and Skin
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