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anti-RNF213 antibody :: Goat RNF213/C17orf27 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420069
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RNF213/C17orf27, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-RNF213/C17orf27 (C Terminus) Antibody

 Product Synonym Names    Goat Anti-RNF213 / C17orf27 (internal) Antibody; RNF213; C17orf27; ring finger protein 213; chromosome 17 open reading frame 27; KIAA1554; RNF213 antibody; C17orf27 antibody; ring finger protein 213 antibody; chromosome 17 open reading frame 27 antibody; KIAA1554 antibody; RNF213 / C17orf27 (C Terminus)
 Product Gene Name   

anti-RNF213 antibody

[Similar Products]
 Product Synonym Gene Name    C17orf27 [Similar Products]
 Antibody/Peptide Pairs    RNF213 / C17orf27 peptide (MBS426777) is used for blocking the activity of RNF213/C17orf27 antibody (MBS420069)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KTAAVLKWNR E
 OMIM    607151
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KTAAVLKWNRE, from the C Terminus of the protein sequence according to NP_065965.4.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-RNF213 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RNF213 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-RNF213 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Immunohistochemistry: In paraffin embedded human kidney shows rare staining of nucleoli across the kidney. Recommended concentration, 2.5ug/ml.
Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as large as the calculated size of 374kDa according to NP_065965.3. Therefore we cannot recommend an optimal concentration and the product is investigative grade.
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 Immunohistochemistry (IHC) of anti-RNF213 antibody    (2.5ug/ml) staining of paraffin embedded human kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining
anti-RNF213 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RNF213. It may not necessarily be applicable to this product.
 NCBI GI #    262231746
 NCBI GeneID    57674
 NCBI Accession #    NP_065965.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_020914.4 [Other Products]
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 UniProt Secondary Accession #    Q658P6; Q69YK7; Q6MZR1; Q8IWF4; Q8IZX1; Q8IZX2; Q8N406; Q8TEU0; C9JCP4; D6RI12; F8WKS1 [Other Products]
 UniProt Related Accession #    Q63HN8 [Other Products]
 Molecular Weight    64,260 Da
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 NCBI Official Synonym Full Names    ring finger protein 213
 NCBI Official Symbol    RNF213 [Similar Products]
 NCBI Official Synonym Symbols   
ALO17; MYMY2; MYSTR; NET57; C17orf27; KIAA1618
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase RNF213
 UniProt Protein Name    E3 ubiquitin-protein ligase RNF213
 UniProt Synonym Protein Names   
ALK lymphoma oligomerization partner on chromosome 17
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    RNF213 [Similar Products]
 UniProt Entry Name    RN213_HUMAN
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 NCBI Summary for RNF213    This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
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 UniProt Comments for RNF213    RNF213: Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity. Defects in RNF213 are the cause of susceptibility to Moyamoya disease type 2 (MYMY2). A progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults. A chromosomal aberration involving ALO17 is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALK. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Oncoprotein; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cytoplasm; cytosol; membrane; nucleolus

Molecular Function: ATPase activity; ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: angiogenesis; protein autoubiquitination; protein homooligomerization; protein polyubiquitination; protein ubiquitination; sprouting angiogenesis; ubiquitin-dependent protein catabolic process
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 Research Articles on RNF213    1. RNF213 was not associated with bipolar disorder or schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RNF213 antibodyPathways associated with anti-RNF213 antibody
 Reference Product  PubMed Publications
 CLTC antibody  >1 publications with RNF213 and CLTC
 TFG antibody  >1 publications with RNF213 and TFG
 NF1 antibody  >1 publications with RNF213 and NF1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-RNF213 antibodyOrgans/Tissues associated with anti-RNF213 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >34 publications with RNF213 and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with RNF213 and Disease Models, Animal
 Hypertension Antibodies  >3 publications with RNF213 and Hypertension
 Hyperplasia Antibodies  >3 publications with RNF213 and Hyperplasia
 Chromosome Aberrations Antibodies  >3 publications with RNF213 and Chromosome Aberrations
 Atherosclerosis Antibodies  >2 publications with RNF213 and Atherosclerosis
 Breast Neoplasms Antibodies  >1 publications with RNF213 and Breast Neoplasms
 Edema Antibodies  >1 publications with RNF213 and Edema
 Neoplasms, Experimental Antibodies  >1 publications with RNF213 and Neoplasms, Experimental
 Neurobehavioral Manifestations Antibodies  >1 publications with RNF213 and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >29 publications with RNF213 and Vascular
 Blood Antibodies  >15 publications with RNF213 and Blood
 Brain Antibodies  >14 publications with RNF213 and Brain
 Muscle Antibodies  >2 publications with RNF213 and Muscle
 Heart Antibodies  >2 publications with RNF213 and Heart
 Connective Tissue Antibodies  >2 publications with RNF213 and Connective Tissue
 Spleen Antibodies  >1 publications with RNF213 and Spleen
 Umbilical Cord Antibodies  >1 publications with RNF213 and Umbilical Cord
 Embryonic Tissue Antibodies  >1 publications with RNF213 and Embryonic Tissue
 Mammary Gland Antibodies  >1 publications with RNF213 and Mammary Gland
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