NP_001292473.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
E3 ubiquitin-protein ligase RNF43 isoform 1
NCBI Official Synonym Full Names
ring finger protein 43
NCBI Official Synonym Symbols
NCBI Protein Information
E3 ubiquitin-protein ligase RNF43
UniProt Protein Name
E3 ubiquitin-protein ligase RNF43
UniProt Synonym Protein Names
RING finger protein 43
UniProt Entry Name
RNF43_HUMAN
NCBI Summary for RNF43
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
UniProt Comments for RNF43
RNF43: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Belongs to the ZNRF3 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; EC 6.3.2.-; Membrane protein, integral; Ubiquitin ligase; Ligase
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; nuclear envelope
Molecular Function: protein binding; zinc ion binding; frizzled binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination
Research Articles on RNF43
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Products associated with anti-RNF43 antibody
Pathways associated with anti-RNF43 antibody
Diseases associated with anti-RNF43 antibody
Organs/Tissues associated with anti-RNF43 antibody
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