NP_071765.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
roundabout homolog 3
NCBI Official Synonym Full Names
roundabout, axon guidance receptor, homolog 3 (Drosophila)
NCBI Official Synonym Symbols
HGPS; RIG1; HGPPS; RBIG1; FLJ21044 [Similar Products]
NCBI Protein Information
roundabout homolog 3; OTTHUMP00000231536; OTTHUMP00000236847; roundabout-like protein 3; retinoblastoma inhibiting gene 1
UniProt Protein Name
Roundabout homolog 3
UniProt Synonym Protein Names
Roundabout-like protein 3
UniProt Entry Name
ROBO3_HUMAN
NCBI Summary for ROBO3
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq]
UniProt Comments for ROBO3
ROBO3: Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing. Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS). Patients show a medulla where motor and sensory projections appear uncrossed. Belongs to the immunoglobulin superfamily. ROBO family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component: axon; integral to membrane
Biological Process: axon guidance; neuron migration; axon midline choice point recognition
Disease: Gaze Palsy, Familial Horizontal, With Progressive Scoliosis
Research Articles on ROBO3
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Pathways associated with anti-ROBO3 antibody
Diseases associated with anti-ROBO3 antibody
Organs/Tissues associated with anti-ROBO3 antibody
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