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anti-RPS6KA1 antibody :: Rabbit anti-Human RPS6K1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150766
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RPS6K1 (RPS6KA1), Polyclonal Antibody

 Also Known As   

RPS6K1 Antibody

 Product Synonym Names    RPS6K1; RSK; HU-1; RSK1; MAPKAPK1A; Ribosomal protein S6 kinase alpha-1; 90 kDa ribosomal protein S6 kinase 1; S6K-alpha-1; ribosomal protein S6 kinase, 90kDa, polypeptide 1
 Product Gene Name   

anti-RPS6KA1 antibody

[Similar Products]
 Antibody/Peptide Pairs    RPS6K1 peptide (MBS152754) is used for blocking the activity of RPS6K1 antibody (MBS150766)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601684
 3D Structure    ModBase 3D Structure for Q15418
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    RPS6K1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    RPS6K1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human RPS6K1.
 Buffer    RPS6K1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    RPS6K1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-RPS6KA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RPS6KA1 antibody

   RPS6K1 Antibody: Ribosomal protein S6 kinase 1 (RPS6K1) is the best characterized effector of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Nutrients and growth factors stimulate a complex including TOR, raptor (regulatory associated protein of TOR), and GbetaL to phosphorylate RPS6K1 and the eukaryotic initiation factor 4E binding protein (4EBP1), leading to increased protein synthesis and cell growth. RPS6K1 is thought to desensitize tissues to insulin as mice deficient in RPS6K1 have been shown to be hypersensitive to insulin and impervious to obesity-induced insulin resistance seen in wild type obese mice.
 Applications Tested/Suitable for anti-RPS6KA1 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-RPS6KA1 antibody    RPS6K1antibody can be used for the detection of RPS6K1 by Western blot at 2.5 - 10 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-RPS6KA1 antibody    Western blot analysis of RPS6K1 in Jurkat cell lysate with RPS6K1 antibody at (A) 2.5, (B) 5 and (C) 10 μg/mL.
anti-RPS6KA1 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-RPS6KA1 antibody    Immunocytochemistry of RPS6K1 in Jurkat cells with RPS6K1 antibody at 10 μg/mL.
anti-RPS6KA1 antibody Immunocytochemistry (ICC) (ICC) image
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 Immunofluorescence (IF) of anti-RPS6KA1 antibody    Immunofluorescence of RP S6 Kinase in Jurkat cells with RP S6 Kinase antibody at 20 μg/mL.
anti-RPS6KA1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for RPS6KA1. It may not necessarily be applicable to this product.
 NCBI GI #    292457
 NCBI GeneID    6195
 NCBI Accession #    AAC82497 [Other Products]
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 UniProt Primary Accession #    Q15418 [Other Products]
 UniProt Secondary Accession #    Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2; A6NGG4; A8K9K7; B2RDY8; B7Z5J0 [Other Products]
 UniProt Related Accession #    Q15418 [Other Products]
 Molecular Weight    72,698 Da
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 NCBI Official Full Name    ribosomal protein S6 kinase 1
 NCBI Official Synonym Full Names    ribosomal protein S6 kinase, 90kDa, polypeptide 1
 NCBI Official Symbol    RPS6KA1 [Similar Products]
 NCBI Official Synonym Symbols   
RSK; HU-1; RSK1; p90Rsk; MAPKAPK1A
[Similar Products]
 NCBI Protein Information    ribosomal protein S6 kinase alpha-1; RSK-1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; MAPK-activated protein kinase 1a; ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
 UniProt Protein Name    Ribosomal protein S6 kinase alpha-1
 UniProt Synonym Protein Names   
90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1
 Protein Family    Ribosomal protein S6 kinase
 UniProt Gene Name    RPS6KA1 [Similar Products]
 UniProt Synonym Gene Names    MAPKAPK1A; RSK1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1 [Similar Products]
 UniProt Entry Name    KS6A1_HUMAN
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 NCBI Summary for RPS6KA1    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RPS6KA1    p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Translation; EC 2.7.11.1; AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: 1p

Cellular Component: nucleoplasm; cytoplasm; spindle; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; protein serine/threonine/tyrosine kinase activity; magnesium ion binding; ATP binding

Biological Process: regulation of transcription in response to stress; axon guidance; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; regulation of translation in response to stress; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; signal transduction; cell cycle; protein amino acid phosphorylation; positive regulation of cell growth; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; synaptic transmission; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of apoptosis
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 Research Articles on RPS6KA1    1. Data suggest that the ribosomal S6 kinase : protein kinase B (AKT) phosphorylation ratio could be useful as a biomarker of target inhibition by RAD001.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RPS6KA1 antibodyPathways associated with anti-RPS6KA1 antibody
 Reference Product  PubMed Publications
 MAPK1 antibody  >31 publications with RPS6KA1 and MAPK1
 MAPK3 antibody  >28 publications with RPS6KA1 and MAPK3
 RPS6 antibody  >7 publications with RPS6KA1 and RPS6
 TSC2 antibody  >7 publications with RPS6KA1 and TSC2
 TSC1 antibody  >5 publications with RPS6KA1 and TSC1
 CREB1 antibody  >4 publications with RPS6KA1 and CREB1
 EEF2K antibody  >3 publications with RPS6KA1 and EEF2K
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CREB Phosphorylation Pathway antibodies  CREB Phosphorylation Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
Diseases associated with anti-RPS6KA1 antibodyOrgans/Tissues associated with anti-RPS6KA1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >16 publications with RPS6KA1 and Inflammation
 Nervous System Diseases Antibodies  >13 publications with RPS6KA1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >11 publications with RPS6KA1 and Disease Models, Animal
 Hypertrophy Antibodies  >11 publications with RPS6KA1 and Hypertrophy
 Liver Diseases Antibodies  >10 publications with RPS6KA1 and Liver Diseases
 Breast Neoplasms Antibodies  >9 publications with RPS6KA1 and Breast Neoplasms
 Necrosis Antibodies  >7 publications with RPS6KA1 and Necrosis
 Hyperplasia Antibodies  >6 publications with RPS6KA1 and Hyperplasia
 Adenocarcinoma Antibodies  >5 publications with RPS6KA1 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >5 publications with RPS6KA1 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >50 publications with RPS6KA1 and Muscle
 Blood Antibodies  >32 publications with RPS6KA1 and Blood
 Liver Antibodies  >27 publications with RPS6KA1 and Liver
 Brain Antibodies  >26 publications with RPS6KA1 and Brain
 Heart Antibodies  >23 publications with RPS6KA1 and Heart
 Lung Antibodies  >10 publications with RPS6KA1 and Lung
 Vascular Antibodies  >9 publications with RPS6KA1 and Vascular
 Connective Tissue Antibodies  >7 publications with RPS6KA1 and Connective Tissue
 Bone Antibodies  >6 publications with RPS6KA1 and Bone
 Embryonic Tissue Antibodies  >5 publications with RPS6KA1 and Embryonic Tissue
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