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anti-RPS6KA6 antibody :: Rabbit RPS6KA6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2523029
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RPS6KA6, Polyclonal Antibody

★Popular Item★
 Also Known As   

RPS6KA6 Polyclonal Antibody

 Product Synonym Names    RSK4; PP90RSK4
 Product Gene Name   

anti-RPS6KA6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300303
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.2mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human RPS6KA6
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RPS6KA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RPS6KA6 antibody

   This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways.
 Product Categories/Family for anti-RPS6KA6 antibody    Epigenetics
 Applications Tested/Suitable for anti-RPS6KA6 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-RPS6KA6 antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-RPS6KA6 antibody    Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using RPS6KA6 Polyclonal Antibody at dilution 1:20
anti-RPS6KA6 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-RPS6KA6 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using RPS6KA6 Polyclonal Antibody at dilution 1:20
anti-RPS6KA6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RPS6KA6. It may not necessarily be applicable to this product.
 NCBI GI #    7657526
 NCBI GeneID    27330
 NCBI Accession #    NP_055311.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014496.4 [Other Products]
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 UniProt Secondary Accession #    Q6FHX2; Q8WX28; Q9H4S6; B2R854; B7ZL90 [Other Products]
 UniProt Related Accession #    Q9UK32 [Other Products]
 Molecular Weight    84,093 Da
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 NCBI Official Full Name    ribosomal protein S6 kinase alpha-6
 NCBI Official Synonym Full Names    ribosomal protein S6 kinase, 90kDa, polypeptide 6
 NCBI Official Symbol    RPS6KA6 [Similar Products]
 NCBI Official Synonym Symbols   
RSK4; PP90RSK4
[Similar Products]
 NCBI Protein Information    ribosomal protein S6 kinase alpha-6; 90 kDa ribosomal protein S6 kinase 6; RSK-4; S6K-alpha 6; S6K-alpha-6; p90-RSK 6; p90RSK6; ribosomal S6 kinase 4
 UniProt Protein Name    Ribosomal protein S6 kinase alpha-6
 UniProt Synonym Protein Names   
90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; Ribosomal S6 kinase 4; RSK-4; pp90RSK4
 Protein Family    Ribosomal protein S6 kinase
 UniProt Gene Name    RPS6KA6 [Similar Products]
 UniProt Synonym Gene Names    RSK4; S6K-alpha-6; p90-RSK 6; p90RSK6; RSK-4 [Similar Products]
 UniProt Entry Name    KS6A6_HUMAN
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 NCBI Summary for RPS6KA6    This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
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 UniProt Comments for RPS6KA6    RSK4: an AGC kinase of the RSK family. Phosphorylates a wide range of substrates including ribosomal protein S6. Implicated in the activation of the mitogen- activated kinase cascade. May play a role in normal neuronal development.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.1; AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: Xq21

Cellular Component: nucleoplasm; mitochondrion; nucleolus; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: axon guidance; negative regulation of embryonic development; synaptic transmission; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; central nervous system development; signal transduction; protein amino acid phosphorylation
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 Research Articles on RPS6KA6    1. RSK4 mRNA is significantly decreased in most of breast cancer tissues compared with paired non-cancerous tissues, due to promoter hypermethylation; frequent epigenetic inactivation might have a role in precancerous lesions or early cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RPS6KA6 antibodyPathways associated with anti-RPS6KA6 antibody
 Reference Product  PubMed Publications
 RPS6KA2 antibody  >2 publications with RPS6KA6 and RPS6KA2
 RPS6KA3 antibody  >1 publications with RPS6KA6 and RPS6KA3
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Long-term Potentiation Pathway antibodies  Long-term Potentiation Pathway Diagram
 Long-term Potentiation Pathway antibodies  Long-term Potentiation Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
Diseases associated with anti-RPS6KA6 antibodyOrgans/Tissues associated with anti-RPS6KA6 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >3 publications with RPS6KA6 and Adenocarcinoma
 Kidney Diseases Antibodies  >3 publications with RPS6KA6 and Kidney Diseases
 Neoplasm Metastasis Antibodies  >3 publications with RPS6KA6 and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >2 publications with RPS6KA6 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with RPS6KA6 and Carcinoma, Hepatocellular
 Endometrial Neoplasms Antibodies  >1 publications with RPS6KA6 and Endometrial Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >5 publications with RPS6KA6 and Kidney
 Brain Antibodies  >2 publications with RPS6KA6 and Brain
 Prostate Antibodies  >1 publications with RPS6KA6 and Prostate
 Embryonic Tissue Antibodies  >1 publications with RPS6KA6 and Embryonic Tissue
 Uncharacterized Tissue Antibodies  >1 publications with RPS6KA6 and Uncharacterized Tissue
 Lung Antibodies  >1 publications with RPS6KA6 and Lung
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