NP_001096139.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,196 Da
NCBI Official Full Name
ras-related protein R-Ras2 isoform b
NCBI Official Synonym Full Names
related RAS viral (r-ras) oncogene homolog 2
NCBI Official Synonym Symbols
NCBI Protein Information
ras-related protein R-Ras2
UniProt Protein Name
Ras-related protein R-Ras2
UniProt Synonym Protein Names
Ras-like protein TC21; Teratocarcinoma oncogene
UniProt Synonym Gene Names
UniProt Entry Name
RRAS2_HUMAN
NCBI Summary for RRAS2
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
UniProt Comments for RRAS2
RRas2: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC). The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein; G protein, monomeric, Ras; Oncoprotein; Motility/polarity/chemotaxis; G protein, monomeric
Chromosomal Location of Human Ortholog: 11p15.2
Cellular Component: focal adhesion; membrane
Molecular Function: GTPase activity; protein binding
Biological Process: osteoblast differentiation
Research Articles on RRAS2
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Products associated with anti-RRAS2 antibody
Pathways associated with anti-RRAS2 antibody
Diseases associated with anti-RRAS2 antibody
Organs/Tissues associated with anti-RRAS2 antibody
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