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anti-RTCB antibody :: Rabbit anti-Human, Mouse RTCB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051688
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RTCB, Polyclonal Antibody

★Popular Item★
 Also Known As   

RTCB Antibody

 Product Synonym Names    tRNA-splicing ligase RtcB homologUniRule annotation; RTCB
 Product Gene Name   

anti-RTCB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AL050255 mRNA
 3D Structure    ModBase 3D Structure for Q9Y3I0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human tRNA-splicing ligase RtcB homolog protein (52-229AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-86491 / sc-86492
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RTCB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RTCB antibody

   Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3', 5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
 Applications Tested/Suitable for anti-RTCB antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-RTCB antibody    WB: 1: 1000-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-RTCB antibody    Western Blot
Positive WB detected in:NIH/3T3 whole cell lysate,HEK293 whole cell lysate
All lanes: RTCB antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56 kDa
Observed band size: 56 kDa

anti-RTCB antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RTCB antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7051688 at dilution of 1:100
anti-RTCB antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-RTCB antibody    Immunohistochemistry of paraffin-embedded human glioma cancer using MBS7051688 at dilution of 1:100
anti-RTCB antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-RTCB antibody    Immunofluorescent analysis of Hela cells using MBS7051688 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-RTCB antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for RTCB. It may not necessarily be applicable to this product.
 NCBI GI #    7657015
 NCBI GeneID    51493
 NCBI Accession #    NP_055121.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014306.4 [Other Products]
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 UniProt Primary Accession #    Q9Y3I0 [Other Products]
 UniProt Secondary Accession #    Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; B2R6A8 [Other Products]
 UniProt Related Accession #    Q9Y3I0 [Other Products]
 Molecular Weight    55,210 Da
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 NCBI Official Full Name    tRNA-splicing ligase RtcB homolog
 NCBI Official Synonym Full Names    RNA 2',3'-cyclic phosphate and 5'-OH ligase
 NCBI Official Symbol    RTCB [Similar Products]
 NCBI Official Synonym Symbols   
FAAP; HSPC117; C22orf28; DJ149A16.6
[Similar Products]
 NCBI Protein Information    tRNA-splicing ligase RtcB homolog
 UniProt Protein Name    tRNA-splicing ligase RtcB homolog
 Protein Family    RNA-splicing ligase
 UniProt Gene Name    RTCB [Similar Products]
 UniProt Entry Name    RTCB_HUMAN
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 UniProt Comments for RTCB    RTCB: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs. Belongs to the RtcB family.

Protein type: EC 6.5.1.3

Chromosomal Location of Human Ortholog: 22q12

Cellular Component: cytoplasm; endoplasmic reticulum membrane; nuclear envelope; nucleoplasm; nucleus

Molecular Function: protein binding; RNA ligase (ATP) activity; vinculin binding

Biological Process: tRNA splicing
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 Research Articles on RTCB    1. RTCB, the catalytic subunit of the tRNA ligase complex, and its co-factor archease mediate XBP1 mRNA splicing both in vitro and in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RTCB antibodyPathways associated with anti-RTCB antibody
 Reference Product  PubMed Publications
 RTCA antibody  >7 publications with RTCB and RTCA
 C22orf28 antibody  >2 publications with RTCB and C22orf28
 ZBTB8OS antibody  >1 publications with RTCB and ZBTB8OS
 DDX1 antibody  >1 publications with RTCB and DDX1
 C14orf166 antibody  >1 publications with RTCB and C14orf166
 C2orf49 antibody  >1 publications with RTCB and C2orf49
 FAM98B antibody  >1 publications with RTCB and FAM98B
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TRNA Processing Pathway antibodies  TRNA Processing Pathway Diagram
 TRNA Processing In The Nucleus Pathway antibodies  TRNA Processing In The Nucleus Pathway Diagram
Diseases associated with anti-RTCB antibodyOrgans/Tissues associated with anti-RTCB antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with RTCB and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with RTCB and Blood
 Eye Antibodies  >1 publications with RTCB and Eye
 Brain Antibodies  >1 publications with RTCB and Brain
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