NP_001015055.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 63 kDa Predicted: 63 kDa
NCBI Official Full Name
rhotekin isoform a
NCBI Official Synonym Full Names
rhotekin
NCBI Protein Information
rhotekin
UniProt Protein Name
Rhotekin
NCBI Summary for RTKN
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for RTKN
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
Research Articles on RTKN
Precautions
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Disclaimer
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Products associated with anti-RTKN antibody
Pathways associated with anti-RTKN antibody
Diseases associated with anti-RTKN antibody
Organs/Tissues associated with anti-RTKN antibody
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