NP_001035541.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,489 Da
NCBI Official Full Name
RUN and FYVE domain-containing protein 1 isoform b
NCBI Official Synonym Full Names
RUN and FYVE domain containing 1
NCBI Protein Information
RUN and FYVE domain-containing protein 1
UniProt Protein Name
RUN and FYVE domain-containing protein 1
UniProt Synonym Protein Names
FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; Zinc finger FYVE domain-containing protein 12
UniProt Synonym Gene Names
UniProt Entry Name
RUFY1_HUMAN
NCBI Summary for RUFY1
This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for RUFY1
RUFY1: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleus
Molecular Function: protein binding
Research Articles on RUFY1
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Pathways associated with anti-RUFY1 antibody
Organs/Tissues associated with anti-RUFY1 antibody
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