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anti-RUNX1T1 antibody :: Rabbit anti-Human RUNX1T1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045567
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RUNX1T1, Polyclonal Antibody

★Popular Item★
 Also Known As   

RUNX1T1 Antibody

 Product Synonym Names    Protein CBFA2T1; Cyclin-D-related protein; Eight twenty one protein; Protein ETO; Protein MTG8; Zinc finger MYND domain-containing prote; RUNX1T1; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
 Product Gene Name   

anti-RUNX1T1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    133435
 3D Structure    ModBase 3D Structure for Q06455
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Protein CBFA2T1 protein
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9737 / sc-9736 / sc-28693
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RUNX1T1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RUNX1T1 antibody

   Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity).
 Applications Tested/Suitable for anti-RUNX1T1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-RUNX1T1 antibody    Western Blot
Positive WB detected in:HepG2 whole cell lysate,Jurkat whole cell lysate
All lanes: RUNX1T1 antibody at 2.8ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 68,65,69,64,49,45 kDa
Observed band size: 68 kDa

anti-RUNX1T1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RUNX1T1 antibody    Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7045567 at dilution of 1:100
anti-RUNX1T1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RUNX1T1. It may not necessarily be applicable to this product.
 NCBI GI #    310923090
 NCBI GeneID    862
 NCBI Accession #    NP_001185554.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001198625.1 [Other Products]
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 UniProt Primary Accession #    Q06455 [Other Products]
 UniProt Secondary Accession #    O14784; Q06456; Q14873; Q16239; Q16346; Q16347; Q6IBL1; Q6NXH1; Q7Z4J5; B7Z4P4; E7EPN4 [Other Products]
 UniProt Related Accession #    Q06455 [Other Products]
 Molecular Weight    63,212 Da
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 NCBI Official Full Name    protein CBFA2T1 isoform A
 NCBI Official Synonym Full Names    RUNX1 translocation partner 1
 NCBI Official Symbol    RUNX1T1 [Similar Products]
 NCBI Official Synonym Symbols   
CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1; AML1-MTG8
[Similar Products]
 NCBI Protein Information    protein CBFA2T1
 UniProt Protein Name    Protein CBFA2T1
 UniProt Synonym Protein Names   
Cyclin-D-related protein; Eight twenty one protein; Protein ETO; Protein MTG8; Zinc finger MYND domain-containing protein 2
 Protein Family    Protein
 UniProt Gene Name    RUNX1T1 [Similar Products]
 UniProt Synonym Gene Names    AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2 [Similar Products]
 UniProt Entry Name    MTG8_HUMAN
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 NCBI Summary for RUNX1T1    This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
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 UniProt Comments for RUNX1T1    RUNX1T1: Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12. Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression. Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. Belongs to the CBFA2T family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription regulation

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: cytoplasm; mitochondrion; nuclear matrix; nucleoplasm

Molecular Function: protein binding; transcription corepressor activity

Biological Process: generation of precursor metabolites and energy; negative regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent
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 Research Articles on RUNX1T1    1. Exon splicing patterns in the human RUNX1-RUNX1T1 fusion gene present in acute myeloid leukemia patients have been decoded.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RUNX1T1 antibodyPathways associated with anti-RUNX1T1 antibody
 Reference Product  PubMed Publications
 RUNX1 antibody  >255 publications with RUNX1T1 and RUNX1
 CBFA2T2 antibody  >11 publications with RUNX1T1 and CBFA2T2
 NCOR1 antibody  >9 publications with RUNX1T1 and NCOR1
 SIN3A antibody  >7 publications with RUNX1T1 and SIN3A
 CEBPA antibody  >6 publications with RUNX1T1 and CEBPA
 HDAC1 antibody  >4 publications with RUNX1T1 and HDAC1
 ZBTB16 antibody  >3 publications with RUNX1T1 and ZBTB16
 PRKAR2A antibody  >1 publications with RUNX1T1 and PRKAR2A
 NCOR2 antibody  >1 publications with RUNX1T1 and NCOR2
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-RUNX1T1 antibodyOrgans/Tissues associated with anti-RUNX1T1 antibody
 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >236 publications with RUNX1T1 and Leukemia, Myeloid, Acute
 Disease Models, Animal Antibodies  >8 publications with RUNX1T1 and Disease Models, Animal
 Kidney Diseases Antibodies  >3 publications with RUNX1T1 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >2 publications with RUNX1T1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >2 publications with RUNX1T1 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with RUNX1T1 and Lung Diseases
 Proteinuria Antibodies  >1 publications with RUNX1T1 and Proteinuria
 Abnormalities, Drug-Induced Antibodies  >1 publications with RUNX1T1 and Abnormalities, Drug-Induced
 Inflammation Antibodies  >1 publications with RUNX1T1 and Inflammation
 Urogenital Abnormalities Antibodies  >1 publications with RUNX1T1 and Urogenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >51 publications with RUNX1T1 and Bone
 Brain Antibodies  >12 publications with RUNX1T1 and Brain
 Heart Antibodies  >7 publications with RUNX1T1 and Heart
 Embryonic Tissue Antibodies  >7 publications with RUNX1T1 and Embryonic Tissue
 Kidney Antibodies  >5 publications with RUNX1T1 and Kidney
 Lung Antibodies  >4 publications with RUNX1T1 and Lung
 Connective Tissue Antibodies  >4 publications with RUNX1T1 and Connective Tissue
 Muscle Antibodies  >2 publications with RUNX1T1 and Muscle
 Spleen Antibodies  >2 publications with RUNX1T1 and Spleen
 Pancreas Antibodies  >2 publications with RUNX1T1 and Pancreas
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